Publications by authors named "Larry Pearce"

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Genetic background and oncogenic driver determines the genomic evolution and transcriptomics of mammary tumor metastasis.
Christina R Ross, Karol Szczepanek, Jack Sanford, Gabriel Needle, Tinghu Qiu, Larry Pearce

Commun Biol· August 2025

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Investigating the genomic landscape of mouse models of breast cancer metastasis.
Christina R Ross, Karol Szczepanek, Jack Sanford, Tinghu Qiu, Larry Pearce

bioRxiv· January 2025

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Design, Synthesis, and Characterization of Novel -1 Heterocyclic DAG-Lactones as PKC Activators.
Eleonora Elhalem, Ana Bellomo, Mariana Cooke, Antonella Scravaglieri, Larry V Pearce

J Med Chem· August 2021

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Discovery of Benzopyridone-Based Transient Receptor Potential Vanilloid 1 Agonists and Antagonists and the Structural Elucidation of Their Activity Shift.
Shivaji A Thorat, Yoonji Lee, Aeran Jung, Jihyae Ann, Songyeon Ahn, Larry V Pearce

J Med Chem· January 2021

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Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic.
Jihyae Ann, Ho Shin Kim, Shivaji A Thorat, Hee Kim, Hee-Jin Ha, Larry V Pearce

J Med Chem· January 2020

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Discovery of dual-acting opioid ligand and TRPV1 antagonists as novel therapeutic agents for pain.
Hobin Lee, Songyeon Ahn, Jihyae Ann, Heejin Ha, Young Dong Yoo, Larry V Pearce

Eur J Med Chem· November 2019

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Combination of a Rapidly Penetrating Agonist and a Slowly Penetrating Antagonist Affords Agonist Action of Limited Duration at the Cellular Level.
Larry V Pearce, Jihyae Ann, Peter M Blumberg, Jeewoo Lee

Biomol Ther (Seoul)· September 2019

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Novel Radiolabeled Vanilloid with Enhanced Specificity for Human Transient Receptor Potential Vanilloid 1 (TRPV1).
Larry V Pearce, Jihyae Ann, Aeran Jung, Shivaji A Thorat, Brienna K A Herold

J Med Chem· October 2017

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Discovery of N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea as a potent TRPV1 antagonistic template.
Jihyae Ann, Wei Sun, Xing Zhou, Aeran Jung, Jisoo Baek, Larry V Pearce

Bioorg Med Chem Lett· August 2016

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Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic Potential for Neuroinflammation.
Zhiwei Feng, Larry V Pearce, Yu Zhang, Changrui Xing, Brienna K A Herold

AAPS J· July 2016

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Engineering vanilloid-sensitivity into the rat TRPV2 channel.
Feng Zhang, Sonya M Hanson, Andres Jara-Oseguera, Dmitriy Krepkiy, Chanhyung Bae, Larry V Pearce

Elife· May 2016

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2-Sulfonamidopyridine C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists.
Jihyae Ann, Yooran Ki, Suyoung Yoon, Myeong Seop Kim, Jung-Un Lee, Larry V Pearce

Bioorg Med Chem· March 2016

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Structural insight into tetrameric hTRPV1 from homology modeling, molecular docking, molecular dynamics simulation, virtual screening, and bioassay validations.
Zhiwei Feng, Larry V Pearce, Xiaomeng Xu, Xiaole Yang, Peng Yang

J Chem Inf Model· March 2015

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α-Methylated simplified resiniferatoxin (sRTX) thiourea analogues as potent and stereospecific TRPV1 antagonists.
Ho Shin Kim, Mi-Kyoung Jin, Sang-Uk Kang, Ju-Ok Lim, Phuong-Thao Tran, Larry V Pearce

Bioorg Med Chem Lett· June 2014

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Asymmetric synthesis and receptor activity of chiral simplified resiniferatoxin (sRTX) analogues as transient receptor potential vanilloid 1 (TRPV1) ligands.
Myeong Seop Kim, Yooran Ki, Song Yeon Ahn, Suyoung Yoon, Sung-Eun Kim, Larry V Pearce

Bioorg Med Chem Lett· January 2014

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The carbonate analogues of 5'-halogenated resiniferatoxin as TRPV1 ligands.
Kwang Su Lim, Hobin Lee, Sung Eun Kim, Tae-Hwan Ha, Jihyae Ann, Larry V Pearce

Eur J Med Chem· October 2013

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New transient receptor potential vanilloid subfamily member 1 positron emission tomography radioligands: synthesis, radiolabeling, and preclinical evaluation.
Daisy van Veghel, Jan Cleynhens, Larry V Pearce, Ian A DeAndrea-Lazarus, Peter M Blumberg

ACS Chem Neurosci· April 2013

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Synthesis and biological evaluation of [¹¹C]SB366791: a new PET-radioligand for in vivo imaging of the TRPV1 receptor.
Daisy van Veghel, Jan Cleynhens, Larry V Pearce, Peter M Blumberg, Koen Van Laere

Nucl Med Biol· January 2013

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2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent transient receptor potential vanilloid 1 (TRPV1) antagonists: structure-activity relationships of 2-amino derivatives in the N-(6-trifluoromethylpyridin-3-ylmethyl) C-region.
Myeong Seop Kim, HyungChul Ryu, Dong Wook Kang, Seong-Hee Cho, Sejin Seo, Larry V Pearce

J Med Chem· October 2012

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The SAR analysis of TRPV1 agonists with the α-methylated B-region.
Yongsung Cho, Myeong Seop Kim, Ho Shin Kim, Jihyae Ann, Jiyoun Lee, Larry V Pearce

Bioorg Med Chem Lett· August 2012

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Structure-activity relationships and molecular modeling of the N-(3-pivaloyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl] thiourea template for TRPV1 antagonism.
Rahul S Bhondwe, Dong Wook Kang, Myeong Seop Kim, Ho Shin Kim, Seul-gi Park, Larry V Pearce

Bioorg Med Chem Lett· June 2012

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TRPV1 activation is not an all-or-none event: TRPV1 partial agonism/antagonism and its regulatory modulation.
Peter M Blumberg, Larry V Pearce, Jeewoo Lee

Curr Top Med Chem· May 2012

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2-(4-Methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the B and C-regions.
Wei Sun, Keliang Liu, HyungChul Ryu, Dong Wook Kang, Yong Soo Kim, Larry V Pearce

Bioorg Med Chem· February 2012

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N-4-t-Butylbenzyl 2-(4-methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in the A-region.
Yong Soo Kim, Min-Jung Kil, Sang-Uk Kang, HyungChul Ryu, Myeong Seop Kim, Larry V Pearce

Bioorg Med Chem· January 2012

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Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies.
Jin Hee Lee, Yoonji Lee, HyungChul Ryu, Dong Wook Kang, Jeewoo Lee, Larry V Pearce

J Comput Aided Mol Des· April 2011

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