Publications by authors named "Lars Engelholm"

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Targeting uPARAP with an antibody-drug conjugate exhibits efficacy against mesothelioma and synergizes with cisplatin.
Pınar Çakılkaya, Ida Marie Egeland Larsen, Qun Jiang, Kirstine Sandal Nørregaard, Henrik Gårdsvoll, Lars Henning Engelholm

Cancer Res Commun· December 2025

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β-adrenergic signaling blockade attenuates metastasis through activation of cytotoxic CD4 T cells.
Klaire Yixin Fjæstad, Astrid Zedlitz Johansen, Hannes Linder, Kevin James Baker, Milou Schattefor, Lars Henning Engelholm

Nat Commun· November 2025

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The recycling collagen receptor uPARAP is a unique mediator of stromal drug delivery to carcinoma cells.
Kirstine S Nørregaard, Ida M E Larsen, Henrik J Jürgensen, Michaela Hansen Blomquist, Pınar Çakılkaya, Lars H Engelholm

Mol Cancer Ther· July 2025

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Chronotherapy with Cinacalcet has a striking effect on inhibition of parathyroid gland proliferation in rats with secondary hyperparathyroidism.
Søren Egstrand, Maria Lerche Mace, Marya Morevati, Lars Henning Engelholm, Jesper Skovhus Thomsen

PLoS One· January 2025

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Targeting uPAR with an antibody-drug conjugate suppresses tumor growth and reshapes the immune landscape in pancreatic cancer models.
Virginia Metrangolo, Michaela Hansen Blomquist, Ananya Dutta, Henrik GÃ¥rdsvoll, Oliver Krigslund, Lars H Engelholm

Sci Adv· January 2025

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A HER2 Specific Nanobody-Drug Conjugate: Site-Selective Bioconjugation and In Vitro Evaluation in Breast Cancer Models.
Anders H Hansen, Kasper I H Andersen, Li Xin, Oliver Krigslund, Niels Behrendt, Lars H Engelholm

Molecules· January 2025

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BAG2, MAD2L1, and MDK are cancer-driver genes and candidate targets for novel therapies in malignant pleural mesothelioma.
Luisa Bisceglia, Federica Morani, Lara Guerrieri, Eric Santoni-Rugiu, Pınar Çakılkaya, Lars H Engelholm

Cancer Gene Ther· November 2024

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A proteomics-based survey reveals thrombospondin-4 as a ligand regulated by the mannose receptor in the injured lung.
Kirstine S Nørregaard, Henrik J Jürgensen, Signe S Heltberg, Henrik Gårdsvoll, Thomas H Bugge, Lars H Engelholm

J Biol Chem· May 2024

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Antibody-Drug Conjugates: The Dynamic Evolution from Conventional to Next-Generation Constructs.
Virginia Metrangolo, Lars H Engelholm

Cancers (Basel)· January 2024

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A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoids.
Wojciech Senkowski, Laura Gall-Mas, Matías Marín Falco, Yilin Li, Kari Lavikka, Lars Engelholm

Dev Cell· June 2023

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Targeted delivery of alcohol-containing payloads with antibody-drug conjugates.
Katja E Grier, Anders H Hansen, Christina S Haxvig, Xin Li, Oliver Krigslund, Lars H Engelholm

Chem Commun (Camb)· June 2023

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The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1.
Kirstine S Nørregaard, Henrik J Jürgensen, Signe Z Ingvarsen, Signe S Heltberg, Christina E Hagensen, Lars H Engelholm

Matrix Biol· August 2022

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Hypomorphic expression of parathyroid Bmal1 disrupts the internal parathyroid circadian clock and increases parathyroid cell proliferation in response to uremia.
Søren Egstrand, Maria Lerche Mace, Marya Morevati, Anders Nordholm, Lars Henning Engelholm

Kidney Int· June 2022

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Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment.
Klaire Yixin Fjæstad, Anne Mette Askehøj Rømer, Victor Goitea, Astrid Zedlitz Johansen, Marie-Louise Thorseth, Lars Henning Engelholm

Oncogene· February 2022

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Uncovering mediators of collagen degradation in the tumor microenvironment.
Marie-Louise Thorseth, Marco Carretta, Christina Jensen, Kasper Mølgaard, Henrik J Jürgensen, Lars H Engelholm

Matrix Biol Plus· February 2022

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The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential Diagnostic Marker and Therapeutic Target.
Pınar Çakılkaya, Rikke Raagaard Sørensen, Henrik Jessen Jürgensen, Oliver Krigslund, Henrik Gårdsvoll, Lars H Engelholm

Int J Mol Sci· October 2021

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The Urokinase Receptor (uPAR) as a "Trojan Horse" in Targeted Cancer Therapy: Challenges and Opportunities.
Virginia Metrangolo, Michael Ploug, Lars H Engelholm

Cancers (Basel)· October 2021

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Osteosarcoma and Metastasis Associated Bone Degradation-A Tale of Osteoclast and Malignant Cell Cooperativity.
Kirstine Sandal Nørregaard, Henrik Jessen Jürgensen, Henrik Gårdsvoll, Lars Henning Engelholm, Niels Behrendt

Int J Mol Sci· June 2021

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Tumor cell MT1-MMP is dispensable for osteosarcoma tumor growth, bone degradation and lung metastasis.
Signe Z Ingvarsen, Henrik Gårdsvoll, Sander van Putten, Kirstine S Nørregaard, Oliver Krigslund, Lars H Engelholm

Sci Rep· November 2020

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Personalized B cell response to the probiotic in healthy human subjects: a randomized trial.
Jette Bornholdt, Christa Broholm, Yun Chen, Alfredo Rago, Stine Sloth, Lars Engelholm

Gut Microbes· November 2020

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Cellular uptake of collagens and implications for immune cell regulation in disease.
Henrik J Jürgensen, Sander van Putten, Kirstine S Nørregaard, Thomas H Bugge, Lars H Engelholm

Cell Mol Life Sci· August 2020

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The collagen receptor uPARAP/Endo180 regulates collectins through unique structural elements in its FNII domain.
Kirstine Sandal Nørregaard, Oliver Krigslund, Niels Behrendt, Lars H Engelholm, Henrik Jessen Jürgensen

J Biol Chem· July 2020

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Collagen density regulates the activity of tumor-infiltrating T cells.
Dorota E Kuczek, Anne Mette H Larsen, Marie-Louise Thorseth, Marco Carretta, Adrija Kalvisa, Lars H Engelholm

J Immunother Cancer· March 2019

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CCL2/MCP-1 signaling drives extracellular matrix turnover by diverse macrophage subsets.
Henrik J Jürgensen, Lakmali M Silva, Oliver Krigslund, Sander van Putten, Daniel H Madsen, Lars H Engelholm

Matrix Biol Plus· February 2019

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uPARAP/Endo180 receptor is a gatekeeper of VEGFR-2/VEGFR-3 heterodimerisation during pathological lymphangiogenesis.
Tania Durré, Florent Morfoisse, Charlotte Erpicum, Marie Ebroin, Silvia Blacher, Lars Engelholm

Nat Commun· December 2018

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