Publications by authors named "Lars Fritsche"

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Functional Outcomes Across High-Risk OCT-Based Phenotypes in Intermediate Age-Related Macular Degeneration-PINNACLE Study Report 11.
Marie Louise Enzendorfer, Julia Mai, Sophie Riedl, Hrvoje Bogunovic, Martin J Menten, Lars G Fritsche

Invest Ophthalmol Vis Sci· December 2025

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Asymmetric integration of various cancer datasets for identifying risk-associated variants and genes.
Ruixuan Wang, Lam Tran, Benjamin Brennan, Lars G Fritsche, Kevin He

Bioinform Adv· November 2025

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Using adaptive optics to assess hyporeflective clump speed and size in age-related macular degeneration in the PINNACLE Study. (PINNACLE Study Report 6).
Christopher Holmes, Dimitrios Kazantzis, Syed Ahmer Raza, Naomi Wijesingha, Thomas Rp Taylor, Lars Fritsche

Eye (Lond)· October 2025

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Polygenic prediction of body mass index and obesity through the life course and across ancestries.
Roelof A J Smit, Kaitlin H Wade, Qin Hui, Joshua D Arias, Xianyong Yin, Lars G Fritsche

Nat Med· September 2025

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A Linear Analysis Mixed Model Phenotyper (LAMP) for Bipolar Disorder: Evaluating the Impact of Medication, Substance Use Disorders, and Comorbidities on Mood Trajectories.
Qingzhi Liu, Pranjal Srivastava, Ivan Rozhkov, Gregory A Farnum, Monica J Holmes, Lars G Fritsche

medRxiv· September 2025

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Expanding biobank pharmacogenomics through machine learning calls of structural variation.
Brett Vanderwerff, Amy L Pasternak, Lars G Fritsche, Emily Bertucci-Richter, Snehal Patil

Genetics· July 2025

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Features of intermediate and late dry age-related macular degeneration on adaptive optics ophthalmoscopy: Pinnacle Study Report 8.
Ahmed M Hagag, Christopher Holmes, Ahmer Raza, Sophie Riedl, Philipp Anders, Lars G Fritsche

Eye (Lond)· April 2025

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Correction: Features of intermediate and late dry age-related macular degeneration on adaptive optics ophthalmoscopy: Pinnacle Study Report 8.
Ahmed M Hagag, Christopher Holmes, Ahmer Raza, Sophie Riedl, Philipp Anders, Lars G Fritsche

Eye (Lond)· April 2025

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Assessing the Clinical Utility of Published Prostate Cancer Polygenic Risk Scores in a Large Biobank Data Set.
Randy A Vince, Helen Sun, Udit Singhal, Fredrick R Schumacher, Erika Trapl, Lars G Fritsche

Eur Urol Oncol· February 2025

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Targeted Microperimetry Grids for Focal Lesions in Intermediate AMD: PINNACLE Study Report 7.
Stefan Futterknecht, Philipp Anders, Julia Mai, Sophie Riedl, Ursula Hall, Lars G Fritsche

Invest Ophthalmol Vis Sci· February 2025

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Effectiveness and safety of immune checkpoint inhibitors in Black patients versus White patients in a US national health system: a retrospective cohort study.
Sean Miller, Ralph Jiang, Matthew Schipper, Lars G Fritsche, Garth Strohbehn

Lancet Oncol· December 2024

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Pan-Cancer Survival Impact of Immune Checkpoint Inhibitors in a National Healthcare System.
Sean R Miller, Matthew Schipper, Lars G Fritsche, Ralph Jiang, Garth Strohbehn

Cancer Med· November 2024

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Metadata-enhanced contrastive learning from retinal optical coherence tomography images.
Robbie Holland, Oliver Leingang, Hrvoje Bogunović, Sophie Riedl, Lars Fritsche

Med Image Anal· October 2024

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Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank.
Weijia Jin, Jonathan Boss, Kelly M Bakulski, Stephen A Goutman, Eva L Feldman, Lars G Fritsche

J Neurol· October 2024

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To weight or not to weight? The effect of selection bias in 3 large electronic health record-linked biobanks and recommendations for practice.
Maxwell Salvatore, Ritoban Kundu, Xu Shi, Christopher R Friese, Seunggeun Lee, Lars G Fritsche

J Am Med Inform Assoc· June 2024

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Artificial intelligence to unlock real-world evidence in clinical oncology: A primer on recent advances.
Alex K Bryant, Rafael Zamora-Resendiz, Xin Dai, Destinee Morrow, Yuewei Lin, Lars Fritsche

Cancer Med· June 2024

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A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans.
Marta R Moksnes, Ailin F Hansen, Brooke N Wolford, Laurent F Thomas, Humaira Rasheed, Lars G Fritsche

Commun Biol· April 2024

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Improving prediction models of amyotrophic lateral sclerosis (ALS) using polygenic, pre-existing conditions, and survey-based risk scores in the UK Biobank.
Weijia Jin, Jonathan Boss, Kelly M Bakulski, Stephen A Goutman, Eva L Feldman, Lars G Fritsche

medRxiv· March 2024

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Whole genome sequencing of 4,787 individuals identifies gene-based rare variants in age-related macular degeneration.
Alan Kwong, Matthew Zawistowski, Lars G Fritsche, Xiaowei Zhan, Jennifer Bragg-Gresham

Hum Mol Genet· February 2024

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Incorporating functional annotation with bilevel continuous shrinkage for polygenic risk prediction.
Yongwen Zhuang, Na Yeon Kim, Lars G Fritsche, Bhramar Mukherjee, Seunggeun Lee

BMC Bioinformatics· February 2024

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To weight or not to weight? Studying the effect of selection bias in three large EHR-linked biobanks.
Maxwell Salvatore, Ritoban Kundu, Xu Shi, Christopher R Friese, Seunggeun Lee, Lars G Fritsche

medRxiv· February 2024

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Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.
Anqi Wang, Jiayi Shen, Alex A Rodriguez, Edward J Saunders, Fei Chen, Lars Fritsche

Nat Genet· December 2023

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Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanks.
Lars G Fritsche, Kisung Nam, Jiacong Du, Ritoban Kundu, Maxwell Salvatore

PLoS Genet· December 2023

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Design and analysis heterogeneity in observational studies of COVID-19 booster effectiveness: A review and case study.
Sabir Meah, Xu Shi, Lars G Fritsche, Maxwell Salvatore, Abram Wagner

Sci Adv· December 2023

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Using Multi-Modal Electronic Health Record Data for the Development and Validation of Risk Prediction Models for Long COVID Using the Super Learner Algorithm.
Weijia Jin, Wei Hao, Xu Shi, Lars G Fritsche, Maxwell Salvatore

J Clin Med· November 2023

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