Publications by authors named "Laszlo Hackler"

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Novel drug candidate binds to delta subunit containing GABA receptors and improves spatial memory.
Orsolya Huzián, Lajos István Nagy, László Hackler, Levente Knapp, Ágnes Katalin Kocsis

Biomed Pharmacother· January 2026

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3,3-Bis(hydroxyaryl)oxindoles and Spirooxindoles Bearing a Xanthene Moiety: Synthesis, Mechanism, and Biological Activity.
Dániel Steinsits, Bettina Rávai, Zsolt Kelemen, László Hackler, Viktor Vernyik

J Org Chem· May 2025

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Comparison of humoral and cellular immune responses in hematologic diseases following completed vaccination protocol with BBIBP-CorV, or AZD1222, or BNT162b2 vaccines against SARS-CoV-2.
Enikő Szabó, Szabolcs Modok, Benedek Rónaszéki, Anna Faragó, Nikolett Gémes, László Hackler

Front Med (Lausanne)· July 2023

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Three-Component Reaction of 3-Formyl-6-Methylchromone, Primary Amines, and Secondary Phosphine Oxides: A Synthetic and Mechanistic Study.
Nóra Popovics-Tóth, Trinh Dang Tran Bao, Ádám Tajti, Béla Mátravölgyi, Zsolt Kelemen, László Hackler

ACS Omega· January 2023

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A cytotoxic survey on 2-amino-1H-imidazol based synthetic marine sponge alkaloid analogues.
Nikolett Gémes, Zsófia Makra, Patrícia Neuperger, Enikő Szabó, József Á Balog, László Hackler

Drug Dev Res· December 2022

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Three-component synthesis, utilization and biological activity of phosphinoyl-functionalized isoindolinones.
Nóra Popovics-Tóth, Bettina Rávai, Ádám Tajti, Bence Varga, Péter Bagi, László Hackler

Org Biomol Chem· October 2021

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PMDTA-catalyzed multicomponent synthesis and biological activity of 2-amino-4H-chromenes containing a phosphonate or phosphine oxide moiety.
Ádám Tajti, Kármen Emőke Szabó, Nóra Popovics-Tóth, Javad Iskanderov, Franc Perdih, László Hackler

Org Biomol Chem· August 2021

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Q134R: Small chemical compound with NFAT inhibitory properties improves behavioral performance and synapse function in mouse models of amyloid pathology.
Pradoldej Sompol, Jenna L Gollihue, Susan D Kraner, Irina A Artiushin, Ryan A Cloyd, Laszlo Hackler

Aging Cell· July 2021

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Synthesis and In Vitro Cytotoxicity and Antibacterial Activity of Novel 1,2,3-Triazol-5-yl-phosphonates.
Anna Tripolszky, Emese Tóth, Pál Tamás Szabó, László Hackler, Beáta Kari

Molecules· June 2020

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Single Cell Mass Cytometry Revealed the Immunomodulatory Effect of Cisplatin Via Downregulation of Splenic CD44+, IL-17A+ MDSCs and Promotion of Circulating IFN-γ+ Myeloid Cells in the 4T1 Metastatic Breast Cancer Model.
József Á Balog, László Hackler, Anita K Kovács, Patrícia Neuperger, Róbert Alföldi

Int J Mol Sci· December 2019

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Enantioselective Synthesis of 8-Hydroxyquinoline Derivative, Q134 as a Hypoxic Adaptation Inducing Agent.
László Hackler, Márió Gyuris, Orsolya Huzián, Róbert Alföldi, Gábor J Szebeni

Molecules· November 2019

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Multilevel structure-activity profiling reveals multiple green tea compound families that each modulate ubiquitin-activating enzyme and ubiquitination by a distinct mechanism.
Gabriel Fenteany, Paras Gaur, Lili Hegedűs, Kata Dudás, Ernő Kiss, László Hackler

Sci Rep· September 2019

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The Anti-Inflammatory Role of Mannich Curcuminoids; Special Focus on Colitis.
Gábor J Szebeni, Lajos I Nagy, Anikó Berkó, Alexandra Hoffmann, Liliána Z Fehér, László Hackler

Molecules· April 2019

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Imidazo[1,2-]pyrazole-7-carboxamides Induce Apoptosis in Human Leukemia Cells at Nanomolar Concentrations.
Gábor J Szebeni, József A Balog, András Demjén, Róbert Alföldi, Vanessza L Végi, László Hackler

Molecules· November 2018

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Synthesis and Cytoprotective Characterization of 8-Hydroxyquinoline Betti Products.
Iván Kanizsai, Ramóna Madácsi, László Hackler, Márió Gyuris, Gábor J Szebeni

Molecules· August 2018

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Synthesis, cytotoxic characterization, and SAR study of imidazo[1,2-b]pyrazole-7-carboxamides.
András Demjén, Róbert Alföldi, Anikó Angyal, Márió Gyuris, László Hackler

Arch Pharm (Weinheim)· July 2018

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Achiral Mannich-Base Curcumin Analogs Induce Unfolded Protein Response and Mitochondrial Membrane Depolarization in PANC-1 Cells.
Gábor J Szebeni, Árpád Balázs, Ildikó Madarász, Gábor Pócz, Ferhan Ayaydin, László Hackler

Int J Mol Sci· October 2017

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Mannich Curcuminoids as Potent Anticancer Agents.
Márió Gyuris, László Hackler, Lajos I Nagy, Róbert Alföldi, Eszter Rédei

Arch Pharm (Weinheim)· July 2017

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A novel pleiotropic effect of aspirin: Beneficial regulation of pro- and anti-inflammatory mechanisms in microglial cells.
Diana Kata, Imre Földesi, Liliana Z Feher, Laszlo Hackler, Laszlo G Puskas

Brain Res Bull· June 2017

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The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms.
Tibor Kovács, Viktor Billes, Marcell Komlós, Bernadette Hotzi, Anna Manzéger, Laszlo Hackler

Sci Rep· February 2017

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AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects.
Diána Papp, Tibor Kovács, Viktor Billes, Máté Varga, Anna Tarnóci, László Hackler

Autophagy· December 2016

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The Curcumin Analog C-150, Influencing NF-κB, UPR and Akt/Notch Pathways Has Potent Anticancer Activity In Vitro and In Vivo.
László Hackler, Béla Ózsvári, Márió Gyuris, Péter Sipos, Gabriella Fábián

PLoS One· August 2016

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Endomorphin analog analgesics with reduced abuse liability, respiratory depression, motor impairment, tolerance, and glial activation relative to morphine.
James E Zadina, Mark R Nilges, Jenny Morgenweck, Xing Zhang, Laszlo Hackler

Neuropharmacology· June 2016

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Lipidomic analysis reveals a radiosensitizing role of gamma-linolenic acid in glioma cells.
Otilia Antal, Mária Péter, László Hackler, Imola Mán, Gábor Szebeni

Biochim Biophys Acta· September 2015

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Novel real-time cell analysis platform for the dynamic monitoring of ionizing radiation effects on human tumor cell lines and primary fibroblasts.
Imola Mán, Gábor J Szebeni, Imola Plangár, Emilia R Szabó, Tünde Tőkés, László Hackler

Mol Med Rep· September 2015

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