Publications by authors named "Laura Byrnes"

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Discovery of small molecule modulators of the thin filament that alter the contractile profile in a hypertrophic cardiomyopathy engineered tissue model.
Ruth F Sommese, Samuel M Levi, Janice Brown, Jana Polivkova, Laura J Byrnes

J Biol Chem· November 2025

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Discovery, Characterization, and Structure of a Cell Active PAD2 Inhibitor Acting through a Novel Allosteric Mechanism.
Laura J Byrnes, Won Young Choi, Paul Balbo, Mary Ellen Banker, Jeanne Chang

ACS Chem Biol· October 2024

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In vitro selection and analysis of SARS-CoV-2 nirmatrelvir resistance mutations contributing to clinical virus resistance surveillance.
Yuao Zhu, Irina Yurgelonis, Stephen Noell, Qingyi Yang, Shunjie Guan, Laura J Byrnes

Sci Adv· July 2024

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Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.
Allyn T Londregan, Karlygash Aitmakhanova, James Bennett, Laura J Byrnes, Daniel P Canterbury

J Med Chem· January 2023

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Species differences in plasma protein binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease inhibitor nirmatrelvir.
Siennah R Greenfield, Heather Eng, Qingyi Yang, Chunyang Guo, Laura Byrnes

Xenobiotica· January 2023

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The hypervariable region of atlastin-1 is a site for intrinsic and extrinsic regulation.
Carolyn M Kelly, Laura J Byrnes, Niharika Neela, Holger Sondermann, John P O'Donnell

J Cell Biol· November 2021

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Toward the assembly and characterization of an encoded library hit confirmation platform: Bead-Assisted Ligand Isolation Mass Spectrometry (BALI-MS).
Anokha S Ratnayake, Mark E Flanagan, Timothy L Foley, Scott L Hultgren, Justin Bellenger, Laura J Byrnes

Bioorg Med Chem· July 2021

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Sites associated with Kalydeco binding on human Cystic Fibrosis Transmembrane Conductance Regulator revealed by Hydrogen/Deuterium Exchange.
Laura J Byrnes, Yingrong Xu, Xiayang Qiu, Justin D Hall, Graham M West

Sci Rep· March 2018

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A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core.
John P O'Donnell, Laura J Byrnes, Richard B Cooley, Holger Sondermann

J Biol Chem· January 2018

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The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Justin Hall, Erik C Ralph, Suman Shanker, Hong Wang, Laura J Byrnes

Protein Sci· December 2017

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Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy.
Justin D Hall, Hong Wang, Laura J Byrnes, Suman Shanker, Kelong Wang

Protein Sci· February 2016

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Versatile membrane deformation potential of activated pacsin.
Shih Lin Goh, Qi Wang, Laura J Byrnes, Holger Sondermann

PLoS One· June 2013

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Structural basis for conformational switching and GTP loading of the large G protein atlastin.
Laura J Byrnes, Avtar Singh, Kylan Szeto, Nicole M Benvin, John P O'Donnell

EMBO J· February 2013

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Aminoglycoside 2''-phosphotransferase IIIa (APH(2'')-IIIa) prefers GTP over ATP: structural templates for nucleotide recognition in the bacterial aminoglycoside-2'' kinases.
Clyde A Smith, Marta Toth, Hilary Frase, Laura J Byrnes, Sergei B Vakulenko

J Biol Chem· April 2012

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Molecular mechanism of a green-shifted, pH-dependent red fluorescent protein mKate variant.
Qi Wang, Laura J Byrnes, Bo Shui, Ute F Röhrig, Avtar Singh

PLoS One· January 2012

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Circular permutation of red fluorescent proteins.
Bo Shui, Qi Wang, Frank Lee, Laura J Byrnes, Dmitry M Chudakov

PLoS One· September 2011

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Structural basis for the nucleotide-dependent dimerization of the large G protein atlastin-1/SPG3A.
Laura J Byrnes, Holger Sondermann

Proc Natl Acad Sci U S A· February 2011

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The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamily.
Paul G Young, Rupa Walanj, Vendula Lakshmi, Laura J Byrnes, Peter Metcalf

J Bacteriol· July 2009

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Purification, crystallization and preliminary X-ray analysis of aminoglycoside-2''-phosphotransferase-Ic [APH(2'')-Ic] from Enterococcus gallinarum.
Laura J Byrnes, Adriana Badarau, Sergei B Vakulenko, Clyde A Smith

Acta Crystallogr Sect F Struct Biol Cryst Commun· February 2008

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