Publications by authors named "Laura Siles"

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The Specific Pathogenicity Pattern of the Different Isoforms Conditions Clinical Severity in Inherited Retinal Dystrophies.
Laura Siles, Sheila Ruiz-Nogales, Pilar Méndez-Vendrell, Anniken Burés-Jelstrup, Rafael Navarro

Int J Mol Sci· November 2025

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A dataset of tissue-specific gene expression dynamics during seed development in Brassica.
Hugh Woolfenden, Laura Siles, Martin Vickers, Burkhard Steuernagel, Richard J Morris

Sci Data· May 2025

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Automated dynamic phenotyping of whole oilseed rape () plants from images collected under controlled conditions.
Evangeline Corcoran, Kasra Hosseini, Laura Siles, Smita Kurup, Sebastian Ahnert

Front Plant Sci· May 2025

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Rescue of the disease-associated phenotype in CRISPR-corrected hiPSCs as a therapeutic approach for inherited retinal dystrophies.
Laura Siles, Esther Pomares

Mol Ther Nucleic Acids· March 2025

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The mesodermal and myogenic specification of hESCs depend on ZEB1 and are inhibited by ZEB2.
Chiara Ninfali, Laura Siles, Anna Esteve-Codina, Antonio Postigo

Cell Rep· October 2023

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The EMT factor ZEB1 paradoxically inhibits EMT in BRAF-mutant carcinomas.
Ester Sánchez-Tilló, Leire Pedrosa, Ingrid Vila, Yongxu Chen, Balázs Győrffy, Laura Siles

JCI Insight· October 2023

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A causal inference and Bayesian optimisation framework for modelling multi-trait relationships-Proof-of-concept using Brassica napus seed yield under controlled conditions.
Alexander Calderwood, Laura Siles, Peter J Eastmond, Smita Kurup, Richard J Morris

PLoS One· September 2023

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Efficient correction of variants by CRISPR-Cas9 in hiPSCs derived from Stargardt disease patients.
Laura Siles, Sheila Ruiz-Nogales, Arnau Navinés-Ferrer, Pilar Méndez-Vendrell, Esther Pomares

Mol Ther Nucleic Acids· June 2023

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High-Efficiency CRISPR/Cas9-Mediated Correction of a Homozygous Mutation in Achromatopsia-Patient-Derived iPSCs.
Laura Siles, Paula Gaudó, Esther Pomares

Int J Mol Sci· February 2023

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Automated extraction of pod phenotype data from micro-computed tomography.
Evangeline Corcoran, Laura Siles, Smita Kurup, Sebastian Ahnert

Front Plant Sci· February 2023

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Uncovering Trait Associations Resulting in Maximal Seed Yield in Winter and Spring Oilseed Rape.
Laura Siles, Kirsty L Hassall, Cristina Sanchis Gritsch, Peter J Eastmond, Smita Kurup

Front Plant Sci· September 2021

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Big data from small tissues: extraction of high-quality RNA for RNA-sequencing from different oilseed seed tissues during seed development.
Laura Siles, Peter Eastmond, Smita Kurup

Plant Methods· June 2020

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ZEB1 promotes inflammation and progression towards inflammation-driven carcinoma through repression of the DNA repair glycosylase MPG in epithelial cells.
Oriol de Barrios, Lidia Sanchez-Moral, Marlies Cortés, Chiara Ninfali, Nuria Profitós-Pelejà, Laura Siles

Gut· December 2019

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Epigenetically distinct sister chromatids and asymmetric generation of tumor initiating cells.
Yongqing Liu, Laura Siles, Antonio Postigo, Douglas C Dean

Cell Cycle· November 2019

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ZEB1 protects skeletal muscle from damage and is required for its regeneration.
Laura Siles, Chiara Ninfali, Marlies Cortés, Douglas S Darling, Antonio Postigo

Nat Commun· March 2019

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Transcriptional Regulation of Vitamin E Biosynthesis during Germination of Dwarf Fan Palm Seeds.
Laura Siles, Leonor Alegre, Ariadna González-Solís, Edgar B Cahoon, Sergi Munné-Bosch

Plant Cell Physiol· December 2018

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Regulation of muscle atrophy-related genes by the opposing transcriptional activities of ZEB1/CtBP and FOXO3.
Chiara Ninfali, Laura Siles, Douglas S Darling, Antonio Postigo

Nucleic Acids Res· November 2018

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Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells.
Yongqing Liu, Laura Siles, Xiaoqin Lu, Kevin C Dean, Miriam Cuatrecasas

Nat Commun· June 2018

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ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1.
Oriol de Barrios, Balázs Győrffy, María Jesús Fernández-Aceñero, Ester Sánchez-Tilló, Lidia Sánchez-Moral, Laura Siles

Gut· April 2017

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Enhanced tocopherol levels during early germination events in Chamaerops humilis var. humilis seeds.
Laura Siles, Leonor Alegre, Verónica Tijero, Sergi Munné-Bosch

Phytochemistry· October 2015

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Perennially young: seed production and quality in controlled and natural populations of Cistus albidus reveal compensatory mechanisms that prevent senescence in terms of seed yield and viability.
Maren Müller, Laura Siles, Jana Cela, Sergi Munné-Bosch

J Exp Bot· January 2014

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Vitamin E analyses in seeds reveal a dominant presence of tocotrienols over tocopherols in the Arecaceae family.
Laura Siles, Jana Cela, Sergi Munné-Bosch

Phytochemistry· November 2013

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ZEB1 imposes a temporary stage-dependent inhibition of muscle gene expression and differentiation via CtBP-mediated transcriptional repression.
Laura Siles, Ester Sánchez-Tilló, Jong-Won Lim, Douglas S Darling, Kristen L Kroll

Mol Cell Biol· April 2013

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ZEB1 Promotes invasiveness of colorectal carcinoma cells through the opposing regulation of uPA and PAI-1.
Ester Sánchez-Tilló, Oriol de Barrios, Laura Siles, Pier G Amendola, Douglas S Darling

Clin Cancer Res· March 2013

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EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness.
Ester Sánchez-Tilló, Yongqing Liu, Oriol de Barrios, Laura Siles, Lucia Fanlo

Cell Mol Life Sci· October 2012

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