Publications by authors named "Lawrence D Harris"

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Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective.
Mona Seifert, Subhas C Bera, Pauline van Nies, Robert N Kirchdoerfer, Ashleigh Shannon, Thi-Tuyet-Nhung Le, Xiangzhi Meng, Hongjie Xia, James M Wood, Lawrence D Harris

October 2021

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Broad-Spectrum Peptidomimetic Inhibitors of Norovirus and Coronavirus 3C-like Proteases.
Margaret A Brimble, Louise A Stubbing, Yann O Hermant, Sung-Hyun Yang, Jonathan G Hubert, Lawrence D Harris

ACS Infect Dis· December 2025

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Exploring Phosphate Substitution in Heparan Sulfate Mimetics: Synthesis and Antiviral Evaluation.
Arran W Stewart, Andrew J Marshall, Sam Spijkers-Shaw, Kathy A Keith, Scott H James, Lawrence D Harris

ChemMedChem· November 2025

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Glypican-1 upregulation elicited in response to a cell-impermeable kinase inhibitor and its overexpression enhance HIV-1 infection.
Kelsey Vinzant, Natalia Cheshenko, Heng Pan, Ronald Cutler, Joshua N Buckler, Lawrence D Harris

bioRxiv· October 2025

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An efficient regioconvergent synthesis of 3-aza-obeticholic acid.
Lawrence D Harris, Roselis A Landaeta Aponte, Wanting Jiao, Scott A Cameron, Alex Weymouth-Wilson

Steroids· December 2024

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Activity and cryo-EM structure of the polymerase domain of the human norovirus ProPol precursor.
Alice M McSweeney, Alice-Roza Eruera, Geena M McKenzie-Goldsmith, James C Bouwer, Simon H J Brown, Lawrence D Harris

J Virol· November 2024

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The immune response to RNA suppresses nucleic acid synthesis by limiting ribose 5-phosphate.
Pushpak Bhattacharjee, Die Wang, Dovile Anderson, Joshua N Buckler, Eveline de Geus, Lawrence D Harris

EMBO J· July 2024

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Author Correction: The immune response to RNA suppresses nucleic acid synthesis by limiting ribose 5-phosphate.
Pushpak Bhattacharjee, Die Wang, Dovile Anderson, Joshua N Buckler, Eveline de Geus, Lawrence D Harris

EMBO J· July 2024

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Integrative Molecular Structure Elucidation and Construction of an Extended Metabolic Pathway Associated with an Ancient Innate Immune Response in COVID-19 Patients.
Samuele Sala, Philipp Nitschke, Reika Masuda, Nicola Gray, Nathan G Lawler, Lawrence D Harris

J Proteome Res· March 2024

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Expedient synthesis of imino-C-nucleoside fleximers featuring a one-pot procedure to prepare aryl triazoles.
C H Andy Wong, Jonathan G Hubert, Kevin J Sparrow, Lawrence D Harris, Peter C Tyler

Org Biomol Chem· August 2023

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Galidesivir Triphosphate Promotes Stalling of Dengue-2 Virus Polymerase Immediately Prior to Incorporation.
Sandesh Deshpande, Wenjuan Huo, Rinu Shrestha, Kevin Sparrow, James M Wood, Lawrence D Harris

ACS Infect Dis· August 2023

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Chemoenzymatic Synthesis of 3'-Deoxy-3',4'-didehydro-cytidine triphosphate (ddhCTP).
James H Lee, James M Wood, Steven C Almo, Gary B Evans, Lawrence D Harris

ACS Bio Med Chem Au· August 2023

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An Isomer of Galidesivir That Potently Inhibits Influenza Viruses and Members of the Order.
Kevin J Sparrow, Rinu Shrestha, James M Wood, Keith Clinch, Brett L Hurst, Lawrence D Harris

ACS Med Chem Lett· April 2023

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The discovery of 12β-methyl-17-epi-18-nor-bile acids as potent and selective TGR5 agonists.
Andreas Luxenburger, Lawrence D Harris, Elizabeth M Ure, Wanting Jiao, Anthony D Woolhouse

Eur J Med Chem· March 2023

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3α,7-Dihydroxy-14(13→12)-5β,12α(H),13β(H)-cholan-24-oic Acids Display Neuroprotective Properties in Common Forms of Parkinson's Disease.
Andreas Luxenburger, Hannah Clemmens, Christopher Hastings, Lawrence D Harris, Elizabeth M Ure

Biomolecules· December 2022

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Synthesis of 12β-methyl-18--avicholic acid analogues as potential TGR5 agonists.
Elizabeth M Ure, Lawrence D Harris, Scott A Cameron, Alex Weymouth-Wilson, Richard H Furneaux

Org Biomol Chem· May 2022

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Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication.
Jack Chun-Chieh Hsu, Maudry Laurent-Rolle, Joanna B Pawlak, Hongjie Xia, Amit Kunte, Lawrence D Harris

Mol Cell· May 2022

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Synthesis of Novel C/D Ring Modified Bile Acids.
Roselis A Landaeta Aponte, Andreas Luxenburger, Scott A Cameron, Alex Weymouth-Wilson, Richard H Furneaux, Lawrence D Harris

Molecules· April 2022

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Uncoupling Molecular Testing for SARS-CoV-2 From International Supply Chains.
Jo-Ann L Stanton, Rory O'Brien, Richard J Hall, Anastasia Chernyavtseva, Hye Jeong Ha, Lawrence D Harris

Front Public Health· February 2022

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Discovery of AL-GDa62 as a Potential Synthetic Lethal Lead for the Treatment of Gastric Cancer.
Andreas Luxenburger, Nicola Bougen-Zhukov, Michael G Fraser, Henry Beetham, Lawrence D Harris

J Med Chem· December 2021

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Mechanism-Based Inactivation of Isocitrate Lyase 1 by (2,3)-2-Hydroxy-3-(nitromethyl)succinic acid.
Drake M Mellott, Dan Torres, Inna V Krieger, Scott A Cameron, Zahra Moghadamchargari, Lawrence D Harris

J Am Chem Soc· October 2021

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Synthesis of 12β-Methyl-18--bile Acids.
Andreas Luxenburger, Lawrence D Harris, Elizabeth M Ure, Roselis A Landaeta Aponte, Anthony D Woolhouse

ACS Omega· September 2021

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Chemical Synthesis of the Antiviral Nucleotide Analogue ddhCTP.
James M Wood, Gary B Evans, Tyler L Grove, Steven C Almo, Scott A Cameron, Lawrence D Harris

J Org Chem· July 2021

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Aminofutalosine Deaminase in the Menaquinone Pathway of .
Mu Feng, Rajesh K Harijan, Lawrence D Harris, Peter C Tyler, Richard F G Fröhlich

Biochemistry· June 2021

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Inhibition of SARS-CoV-2 polymerase by nucleotide analogs: a single molecule perspective.
Mona Seifert, Subhas Chandra Bera, Pauline van Nies, Robert N Kirchdoerfer, Ashleigh Shannon, Lawrence D Harris

bioRxiv· April 2021

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