October 2021 PMID 34617885

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective.

Mona Seifert, Subhas C Bera, Pauline van Nies, Robert N Kirchdoerfer, Ashleigh Shannon, Thi-Tuyet-Nhung Le, Xiangzhi Meng, Hongjie Xia, James M Wood, Lawrence D Harris, Flavia S Papini, Jamie J Arnold, Steven Almo, Tyler L Grove, Pei-Yong Shi

Mentions

24
Peak: 16 in Oct 2021
across 2 sources since Oct 2021

Extended reach

13,157
potential audience

Total likes

38

Video views

263

Mentions per month

Oct 2021 – Apr 2022

Where it's discussed

  • X / Twitter22 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions show strong interest, with expressions like 'fascinating tech' and mentions of the research as a 'deep dive,' indicating curiosity and appreciation for innovative methods. Support for the research is evident in comments praising the study and acknowledgment of its significance, with some posts quoting the article’s focus on nucleotide analogs affecting viral polymerase activity, emphasizing the perceived importance of the findings.

AgreementModerate agreement

Most discussions show support and positive acknowledgment of the research findings, reflecting general agreement with the significance of the study.

InterestHigh interest

The posts demonstrate high interest, with mentions of fascinating technology and specific research details that engage the audience.

EngagementModerate engagement

While some posts reference the methodology and implications, the overall depth of discussion remains moderate, indicating a healthy but not overly detailed engagement.

ImpactModerate impact

The shared enthusiasm and references to the potential implications suggest that the research is viewed as impactful, though not yet as transformative or widely disruptive.

Abstract in brief

  • The study investigates how nucleotide analogs like remdesivir affect SARS-CoV-2 RNA polymerase activity, revealing that remdesivir causes backtracking rather than stopping RNA synthesis outright.
  • It highlights that where modifications are made on the nucleotides (ribose or base) influences how they are incorporated into viral RNA, and the virus can sometimes evade certain antiviral drugs.
  • Using a single-molecule magnetics platform, the research enhances our understanding of antiviral drug mechanisms, aiding future development of effective coronavirus treatments.]

Top posts

Most liked on X and Bluesky
David Dulin
@Dulin_Lab · X

We are very happy to see out "Inhibition of #SARSCoV2 polymerase by nucleotide analogs from a #singlemolecule perspective" A thread to explain our findings: @VUamsterdam @VU_Science @FAU_Germany @MPZ_PhysMed 1/14 https://t.co/n0skHQtyXi

Oct 18, 2021 · 23 likes · 6 shares · 920 followers View post →
@MicrobioJC@scicomm.xyz
@microtwjc · X

Last week we presented our Deep Dive on using magnetic tweezers

Jan 23, 2022 · 2 likes · 3 shares · 302 followers View post →
Julien Sourimant
@JulienSourimant · X

Nice to see @Dulin_Lab latest study of nucleotides analogs with magnetic tweezers finally out. Such a fascinating technology, in particular to understand what "delayed chain terminators" actually do! https://t.co/hNC1CAgXjI

Oct 8, 2021 · 2 likes · 1 share · 110 followers View post →
David Dulin
@Dulin_Lab · X

@MPZ_PhysMed @VUamsterdam @tudelft @VU_Science @seifert_mona @b_subhas @FAU_Germany Here is the article! Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective https://t.co/n0skHQtyXi

Oct 8, 2021 · 1 like · 920 followers View post →
SciArt3D
@SciArt3D · X

Antivirales en marcha

Oct 10, 2021 · 1 like · 1 share · 582 followers View post →
Ferrier Research Institute
@Ferrier_Inst · X

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective https://t.co/aZ7d5KcIid

Oct 10, 2021 · 1 like · 1 share · 469 followers View post →

All mentions

Michael J. Young
@mchljyng · X

Thanks for reading! Most of this info is from Seifert et al. 2021 in eLife (including the chemical structures in tweet #2) https://t.co/WbMRfm7Xz1

Apr 21, 2022 · 1 like · 326 followers View post →
Faz Alam
@DefectiveBrayne · X

RT @microtwjc: Last week we presented our Deep Dive on using magnetic tweezers

Jan 23, 2022 · 3 shares · 158 followers View post →
@danwchan@scholar.social
@id_EATER · X

RT @microtwjc: Last week we presented our Deep Dive on using magnetic tweezers

Jan 23, 2022 · 3 shares · 205 followers View post →
Biotech without Borders
@BioWOborders · X

RT @microtwjc: Last week we presented our Deep Dive on using magnetic tweezers

Jan 23, 2022 · 3 shares · 617 followers View post →
@MicrobioJC@scicomm.xyz
@microtwjc · X

Last week we presented our Deep Dive on using magnetic tweezers

Jan 23, 2022 · 2 likes · 3 shares · 302 followers View post →
@MicrobioJC@scicomm.xyz
@microtwjc · X

Choice 1: Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective https://t.co/6ZQApa6yhH

Nov 24, 2021 · 302 followers View post →
Max-Planck-Zentrum für Physik und Medizin
@MPZ_PhysMed · X

RT @Dulin_Lab: We are very happy to see out "Inhibition of #SARSCoV2 polymerase by nucleotide analogs from a #singlemolecule perspective"…

Nov 2, 2021 · 6 shares · 910 followers View post →
francesco.pedaci
@f_pedaci · X

RT @Dulin_Lab: We are very happy to see out "Inhibition of #SARSCoV2 polymerase by nucleotide analogs from a #singlemolecule perspective"…

Oct 19, 2021 · 6 shares · 158 followers View post →
John Marecki
@JCM2FLM · X

RT @Dulin_Lab: We are very happy to see out "Inhibition of #SARSCoV2 polymerase by nucleotide analogs from a #singlemolecule perspective"…

Oct 18, 2021 · 6 shares · 19 followers View post →
Fadhilah
@AraniyF · X

RT @Dulin_Lab: We are very happy to see out "Inhibition of #SARSCoV2 polymerase by nucleotide analogs from a #singlemolecule perspective"…

Oct 18, 2021 · 6 shares · 234 followers View post →
Craig Cameron Lab
@CameronLabUNC · X

RT @Dulin_Lab: We are very happy to see out "Inhibition of #SARSCoV2 polymerase by nucleotide analogs from a #singlemolecule perspective"…

Oct 18, 2021 · 6 shares · 2,768 followers View post →
David Dulin
@Dulin_Lab · X

We are very happy to see out "Inhibition of #SARSCoV2 polymerase by nucleotide analogs from a #singlemolecule perspective" A thread to explain our findings: @VUamsterdam @VU_Science @FAU_Germany @MPZ_PhysMed 1/14 https://t.co/n0skHQtyXi

Oct 18, 2021 · 23 likes · 6 shares · 920 followers View post →
Europe PMC articles
@EuropePMC · X

New from #ERC_Research https://t.co/SQ8ODDlpQp Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective.

Oct 11, 2021 · 1,554 followers View post →
Vyacheslav Filichev
@FilichevLab · X

RT @Ferrier_Inst: Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective https://t.co/aZ7d5KcIid

Oct 10, 2021 · 1 share · 97 followers View post →
Ferrier Research Institute
@Ferrier_Inst · X

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective https://t.co/aZ7d5KcIid

Oct 10, 2021 · 1 like · 1 share · 469 followers View post →
SciArt3D
@SciArt3D · X

RT @SciArt3D: Antivirales en marcha

Oct 10, 2021 · 1 share · 582 followers View post →
SciArt3D
@SciArt3D · X

Antivirales en marcha

Oct 10, 2021 · 1 like · 1 share · 582 followers View post →
David Dulin
@Dulin_Lab · X

@MPZ_PhysMed @VUamsterdam @tudelft @VU_Science @seifert_mona @b_subhas @FAU_Germany Here is the article! Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective https://t.co/n0skHQtyXi

Oct 8, 2021 · 1 like · 920 followers View post →
David Dulin
@Dulin_Lab · X

RT @JulienSourimant: Nice to see @Dulin_Lab latest study of nucleotides analogs with magnetic tweezers finally out. Such a fascinating tech…

Oct 8, 2021 · 1 share · 920 followers View post →
Julien Sourimant
@JulienSourimant · X

Nice to see @Dulin_Lab latest study of nucleotides analogs with magnetic tweezers finally out. Such a fascinating technology, in particular to understand what "delayed chain terminators" actually do! https://t.co/hNC1CAgXjI

Oct 8, 2021 · 2 likes · 1 share · 110 followers View post →
NFTdose
@PaperbirdsH · X

New article: Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective https://t.co/A8eICpfxfS #coronavirus #COVID19 #2019ncov https://t.co/fyOXkabjaR

Oct 7, 2021 · 302 followers View post →
micropapers
@micro_papers · X

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective https://t.co/gDJJ0S3j6E

Oct 7, 2021 · 332 followers View post →