We are very happy to see out "Inhibition of #SARSCoV2 polymerase by nucleotide analogs from a #singlemolecule perspective" A thread to explain our findings: @VUamsterdam @VU_Science @FAU_Germany @MPZ_PhysMed 1/14 https://t.co/n0skHQtyXi
Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective.
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Oct 2021 – Apr 2022Where it's discussed
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X / Twitter22 posts
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YouTube2 videos
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What people are saying
The discussions show strong interest, with expressions like 'fascinating tech' and mentions of the research as a 'deep dive,' indicating curiosity and appreciation for innovative methods. Support for the research is evident in comments praising the study and acknowledgment of its significance, with some posts quoting the article’s focus on nucleotide analogs affecting viral polymerase activity, emphasizing the perceived importance of the findings.
Most discussions show support and positive acknowledgment of the research findings, reflecting general agreement with the significance of the study.
The posts demonstrate high interest, with mentions of fascinating technology and specific research details that engage the audience.
While some posts reference the methodology and implications, the overall depth of discussion remains moderate, indicating a healthy but not overly detailed engagement.
The shared enthusiasm and references to the potential implications suggest that the research is viewed as impactful, though not yet as transformative or widely disruptive.
Abstract in brief
- The study investigates how nucleotide analogs like remdesivir affect SARS-CoV-2 RNA polymerase activity, revealing that remdesivir causes backtracking rather than stopping RNA synthesis outright.
- It highlights that where modifications are made on the nucleotides (ribose or base) influences how they are incorporated into viral RNA, and the virus can sometimes evade certain antiviral drugs.
- Using a single-molecule magnetics platform, the research enhances our understanding of antiviral drug mechanisms, aiding future development of effective coronavirus treatments.]
Top posts
Most liked on X and BlueskyLast week we presented our Deep Dive on using magnetic tweezers
Nice to see @Dulin_Lab latest study of nucleotides analogs with magnetic tweezers finally out. Such a fascinating technology, in particular to understand what "delayed chain terminators" actually do! https://t.co/hNC1CAgXjI
@MPZ_PhysMed @VUamsterdam @tudelft @VU_Science @seifert_mona @b_subhas @FAU_Germany Here is the article! Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective https://t.co/n0skHQtyXi
Antivirales en marcha
Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective https://t.co/aZ7d5KcIid
All mentions
Understanding How Nucleotide Analogs Inhibit SARS-CoV-2 via Single-Molecule Analysis
This video explores how nucleotide analogs like remdesivir impact SARS-CoV-2 RNA polymerase activity, showing that remdesivir induces backtracking rather than halting RNA synthesis, providing insights for antiviral drug…
Mechanisms of Remdesivir and Antibiotics in Viral and Bacterial Treatments
References Long-term stable pandemic control without lockdowns and insights into how remdesivir inhibits SARS-CoV-2 polymerase, causing backtracking rather than outright termination. The study also explores virus…
Thanks for reading! Most of this info is from Seifert et al. 2021 in eLife (including the chemical structures in tweet #2) https://t.co/WbMRfm7Xz1
RT @microtwjc: Last week we presented our Deep Dive on using magnetic tweezers
RT @microtwjc: Last week we presented our Deep Dive on using magnetic tweezers
RT @microtwjc: Last week we presented our Deep Dive on using magnetic tweezers
Last week we presented our Deep Dive on using magnetic tweezers
Choice 1: Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective https://t.co/6ZQApa6yhH
RT @Dulin_Lab: We are very happy to see out "Inhibition of #SARSCoV2 polymerase by nucleotide analogs from a #singlemolecule perspective"…
RT @Dulin_Lab: We are very happy to see out "Inhibition of #SARSCoV2 polymerase by nucleotide analogs from a #singlemolecule perspective"…
RT @Dulin_Lab: We are very happy to see out "Inhibition of #SARSCoV2 polymerase by nucleotide analogs from a #singlemolecule perspective"…
RT @Dulin_Lab: We are very happy to see out "Inhibition of #SARSCoV2 polymerase by nucleotide analogs from a #singlemolecule perspective"…
RT @Dulin_Lab: We are very happy to see out "Inhibition of #SARSCoV2 polymerase by nucleotide analogs from a #singlemolecule perspective"…
We are very happy to see out "Inhibition of #SARSCoV2 polymerase by nucleotide analogs from a #singlemolecule perspective" A thread to explain our findings: @VUamsterdam @VU_Science @FAU_Germany @MPZ_PhysMed 1/14 https://t.co/n0skHQtyXi
New from #ERC_Research https://t.co/SQ8ODDlpQp Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective.
RT @Ferrier_Inst: Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective https://t.co/aZ7d5KcIid
Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective https://t.co/aZ7d5KcIid
RT @SciArt3D: Antivirales en marcha
Antivirales en marcha
@MPZ_PhysMed @VUamsterdam @tudelft @VU_Science @seifert_mona @b_subhas @FAU_Germany Here is the article! Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective https://t.co/n0skHQtyXi
RT @JulienSourimant: Nice to see @Dulin_Lab latest study of nucleotides analogs with magnetic tweezers finally out. Such a fascinating tech…
Nice to see @Dulin_Lab latest study of nucleotides analogs with magnetic tweezers finally out. Such a fascinating technology, in particular to understand what "delayed chain terminators" actually do! https://t.co/hNC1CAgXjI
New article: Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective https://t.co/A8eICpfxfS #coronavirus #COVID19 #2019ncov https://t.co/fyOXkabjaR
Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective https://t.co/gDJJ0S3j6E