Publications by authors named "Lawrence Melvin"

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Discovery of a selective alpha-kinase 1 inhibitor for the rare genetic disease ROSAH syndrome.
Jieqing Fan, Danyang Liu, Zhu Ming, Chunyu Yan, Huaixin Dang, Lawrence Melvin

Nat Commun· September 2025

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Darusentan is a potent inhibitor of endothelin signaling and function in both large and small arteries.
Faquan Liang, Christopher B Glascock, Denise L Schafer, Jennifer Sandoval, LouAnn Cable, Lawrence Melvin

Can J Physiol Pharmacol· August 2010

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Evaluation of the endothelin receptor antagonists ambrisentan, darusentan, bosentan, and sitaxsentan as substrates and inhibitors of hepatobiliary transporters in sandwich-cultured human hepatocytes.
J Craig Hartman, Kenneth Brouwer, Arun Mandagere, Lawrence Melvin, Richard Gorczynski

Can J Physiol Pharmacol· June 2010

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Suppression of HDAC nuclear export and cardiomyocyte hypertrophy by novel irreversible inhibitors of CRM1.
Lauren Monovich, Keith A Koch, Robin Burgis, Ekundayo Osimboni, Thierry Mann, Lawrence S Melvin

Biochim Biophys Acta· May 2009

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A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway.
Erik Bush, Jens Fielitz, Lawrence Melvin, Michael Martinez-Arnold, Timothy A McKinsey

Proc Natl Acad Sci U S A· March 2004

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