Publications by authors named "Lay Khoon Too"

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The 1-Step Versus 2-Step Subretinal Injection Trial (1,2-SIT)-A Randomized Controlled Trial to Compare Drug Reflux Following Subretinal Injection.
Matthew P Simunovic, Zak J Prime, Rhuen Chiou Chow, Emily Han Shao, Zeid Madanat, Lay Khoon Too

Am J Ophthalmol· June 2025

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Sodium Fluorescein as an Optical Label to Evaluate Subretinal Injection.
Matthew P Simunovic, Perach Osaadon, Lay Khoon Too

Retina· January 2023

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Optogenetic restoration of high sensitivity vision with bReaChES, a red-shifted channelrhodopsin.
Lay Khoon Too, Weiyong Shen, Dario A Protti, Atomu Sawatari, Dylan A Black

Sci Rep· November 2022

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Editorial: The Relationships Between Infectious Agents and Dementia.
Lay Khoon Too, Nicholas H Hunt, Noriko Shinjyo

Front Cell Neurosci· February 2022

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Two-step versus 1-step subretinal injection to compare subretinal drug delivery: a randomised study protocol.
Matthew P Simunovic, Emily H Shao, Perach Osaadon, Muhammad Bayu Sasongko, Lay Khoon Too

BMJ Open· December 2021

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SURGICAL RETINAL EXPLANTS AS A SOURCE OF RETINAL PROGENITOR CELLS.
Lay Khoon Too, Weiyong Shen, Zaid Mammo, Perach Osaadon, Mark C Gillies

Retina· September 2021

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Retinal Stem/Progenitor Cells Derived From Adult Müller Glia for the Treatment of Retinal Degeneration.
Lay Khoon Too, Matthew P Simunovic

Front Cell Dev Biol· September 2021

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The Role of Inflammation and Infection in Age-Related Neurodegenerative Diseases: Lessons From Bacterial Meningitis Applied to Alzheimer Disease and Age-Related Macular Degeneration.
Lay Khoon Too, Nicholas Hunt, Matthew P Simunovic

Front Cell Neurosci· March 2021

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Brains, bacteria and behaviors: the role of interferon-gamma in the pathogenesis of pneumococcal meningitis.
Lay Khoon Too, Andrew Mitchell

Neural Regen Res· January 2021

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The distribution of toxic metals in the human retina and optic nerve head: Implications for age-related macular degeneration.
Roger Pamphlett, Svetlana Cherepanoff, Lay Khoon Too, Stephen Kum Jew, Philip A Doble

PLoS One· December 2020

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Double deficiency of toll-like receptors 2 and 4 alters long-term neurological sequelae in mice cured of pneumococcal meningitis.
Lay Khoon Too, Belinda Yau, Alan G Baxter, Iain S McGregor, Nicholas H Hunt

Sci Rep· November 2019

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Blood‒Brain Barrier Pathology and CNS Outcomes in Meningitis.
Belinda Yau, Nicholas H Hunt, Andrew J Mitchell, Lay Khoon Too

Int J Mol Sci· November 2018

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TIGR4 strain causes more severe disease than WU2 strain in a mouse model of Streptococcus pneumoniae meningitis: a common pathogenic role for interferon-γ.
Belinda Yau, Lay Khoon Too, Helen J Ball, Nicholas H Hunt

Microbes Infect· March 2018

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Cuticular Drusen: Clinical Phenotypes and Natural History Defined Using Multimodal Imaging.
Chandrakumar Balaratnasingam, Svetlana Cherepanoff, Rosa Dolz-Marco, Murray Killingsworth, Fred K Chen, Lay Khoon Too

Ophthalmology· January 2018

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Investigation of the Tissue Distribution and Physiological Roles of Indoleamine 2,3-Dioxygenase-2.
Felicita F Jusof, Supun M Bakmiwewa, Silvia Weiser, Lay Khoon Too, Richard Metz

Int J Tryptophan Res· October 2017

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Adult human retinal Müller glia display distinct peripheral and macular expression of CD117 and CD44 stem cell-associated proteins.
Lay Khoon Too, Gary Gracie, Enisa Hasic, Julia H Iwakura, Svetlana Cherepanoff

Acta Histochem· March 2017

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The kynurenine pathway and parasitic infections that affect CNS function.
Nicholas H Hunt, Lay Khoon Too, Loke Tim Khaw, Jintao Guo, Leia Hee

Neuropharmacology· January 2017

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Behavioral and cognitive data in mice with different tryptophan-metabolizing enzymes knocked out.
Lay Khoon Too, Kong M Li, Cacang Suarna, Ghassan J Maghzal, Roland Stocker

Data Brief· December 2016

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Deletion of TDO2, IDO-1 and IDO-2 differentially affects mouse behavior and cognitive function.
Lay Khoon Too, Kong M Li, Cacang Suarna, Ghassan J Maghzal, Roland Stocker

Behav Brain Res· October 2016

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Antibody-induced neutrophil depletion prior to the onset of pneumococcal meningitis influences long-term neurological complications in mice.
Lay Khoon Too, Andrew J Mitchell, Iain S McGregor, Nicholas H Hunt

Brain Behav Immun· August 2016

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Altered behaviour and cognitive function following combined deletion of Toll-like receptors 2 and 4 in mice.
Lay Khoon Too, Iain S McGregor, Alan G Baxter, Nicholas H Hunt

Behav Brain Res· April 2016

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Interferon-γ-Induced Nitric Oxide Synthase-2 Contributes to Blood/Brain Barrier Dysfunction and Acute Mortality in Experimental Streptococcus pneumoniae Meningitis.
Belinda Yau, Andrew J Mitchell, Lay Khoon Too, Helen J Ball, Nicholas H Hunt

J Interferon Cytokine Res· February 2016

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The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis.
Lay Khoon Too, James A McQuillan, Helen J Ball, Masaaki Kanai, Toshikazu Nakamura

Behav Brain Res· August 2014

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Inflammasome-dependent IFN-γ drives pathogenesis in Streptococcus pneumoniae meningitis.
Andrew J Mitchell, Belinda Yau, James A McQuillan, Helen J Ball, Lay Khoon Too

J Immunol· November 2012

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