Publications by authors named "Layla A Alkharashi"

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Cuproptosis Contributes to Cisplatin-Induced Nephrotoxicity: Insights into Thymol's Potential Inhibitory and Protective Effects.
Layla A Al-Kharashi, Amira M Badr, Reem T Atawia, Elshaymaa I Elmongy, Hanan Henidi

Pharmaceuticals (Basel)· November 2025

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Fabrication and appraisal of axitinib loaded PEGylated spanlastics against MCF- 7 and OV- 2774 cell lines using molecular docking methods and in-vitro study.
Randa Mohammed Zaki, Basmah Nasser Aldosari, Layla A Alkharashi, Alyaa Alsalhi, Obaid Afzal

PLoS One· July 2025

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Fabrication and appraisal of targeted axitinib loaded bilosomes for the enhanced breast and ovarian anticancer activity.
Randa Mohammed Zaki, Basmah Nasser Aldosari, Layla A Alkharashi, Alyaa Alsalhi, Fatma I Abo El-Ela

PLoS One· July 2025

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E2F1 activates breast stromal fibroblasts and promotes their paracrine pro-carcinogenic effects.
Layla A Al-Kharashi, Falah H Al-Mohanna, Abdelilah Aboussekhra, Abdelilah Abousekhra

Sci Rep· February 2025

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Thymol Protects against 5-Fluorouracil-Induced Hepatotoxicity via the Regulation of the Akt/GSK-3β Pathway in In Vivo and In Silico Experimental Models.
Yasmen F Mahran, Amira M Badr, Layla A Al-Kharashi, Hanaa N Alajami, Nouf T Aldamry

Pharmaceuticals (Basel)· August 2024

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Pioglitazone enhances cisplatin's impact on triple-negative breast cancer: Role of PPARγ in cell apoptosis.
Qamraa Hamad Alqahtani, Layla Abdullah Alkharashi, Hanaa Alajami, Ishraq Alkharashi, Layan Alkharashi

Saudi Pharm J· May 2024

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Decorin (DCN) Downregulation Activates Breast Stromal Fibroblasts and Promotes Their Pro-Carcinogenic Effects through the IL-6/STAT3/AUF1 Signaling.
Wafaa A Aljagthmi, Manal A Alasmari, Maha H Daghestani, Layla A Al-Kharashi, Falah H Al-Mohanna

Cells· April 2024

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Box Behnken optimization of cubosomes for enhancing the anticancer activity of metformin: Design, characterization, and in-vitro cell proliferation assay on MDA-MB-231 breast and LOVO colon cancer cell lines.
Randa Mohammed Zaki, Layla A Alkharashi, Omnia M Sarhan, Alanood S Almurshedi, Basmah Nasser Aldosari

Int J Pharm X· December 2023

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BALB/c and C57BL/6 mice differ in oxidant and antioxidant responses in innate and adaptive immune cells in an asthma model induced by cockroach allergens.
Layla A Al-Kharashi, Saleh A Alqarni, Sheikh F Ahmad, Naif O Al-Harbi, Sary Alsanea

Int Immunopharmacol· November 2023

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Auranofin Modulates Thioredoxin Reductase/Nrf2 Signaling in Peripheral Immune Cells and the CNS in a Mouse Model of Relapsing-Remitting EAE.
Layla A Al-Kharashi, Naif O Al-Harbi, Sheikh F Ahmad, Sabry M Attia, Mohammad M Algahtani

Biomedicines· September 2023

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Radioprotective Effects of Carvacrol and/or Thymol against Gamma Irradiation-Induced Acute Nephropathy: In Silico and In Vivo Evidence of the Involvement of Insulin-like Growth Factor-1 (IGF-1) and Calcitonin Gene-Related Peptide.
Yasmen F Mahran, Layla A Al-Kharashi, Reem T Atawia, Rawan Turki Alanazi, Amal M Bin Dhahi

Biomedicines· September 2023

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Exposure to Methylmercury at Juvenile Stage Worsens Autism-like Symptoms in Adult BTBR T+tf/J Mice Due to Lack of Nuclear Factor Erythroid 2-Related Factor 2 Signaling Upregulation in Periphery and Brain.
Mohammad M Algahtani, Sheikh F Ahmad, Layla A Alkharashi, Naif O Al-Harbi, Wael A Alanazi

Toxics· June 2023

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TLR4/Inflammasomes Cross-Talk and Pyroptosis Contribute to N-Acetyl Cysteine and Chlorogenic Acid Protection against Cisplatin-Induced Nephrotoxicity.
Amira M Badr, Layla A Al-Kharashi, Hala Attia, Samiyah Alshehri, Hanaa N Alajami

Pharmaceuticals (Basel)· February 2023

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IL-17/Notch1/STAT3 Pathway Contributes to 5-Fluorouracil-Induced Intestinal Mucositis in Rats: Amelioration by Thymol Treatment.
Amira M Badr, Layla A Alkharashi, Iman O Sherif, Alaa A Alanteet, Hind N Alotaibi

Pharmaceuticals (Basel)· November 2022

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High DNMT1 Expression in Stromal Fibroblasts Promotes Angiogenesis and Unfavorable Outcome in Locally Advanced Breast Cancer Patients.
Layla A Al-Kharashi, Asma Tulbah, Maria Arafah, Abdelmonneim M Eldali, Taher Al-Tweigeri

Front Oncol· June 2022

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Formulation of Chitosan-Coated Brigatinib Nanospanlastics: Optimization, Characterization, Stability Assessment and In-Vitro Cytotoxicity Activity against H-1975 Cell Lines.
Randa Mohammed Zaki, Munerah M Alfadhel, Saad M Alshahrani, Ahmed Alsaqr, Layla A Al-Kharashi

Pharmaceuticals (Basel)· March 2022

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Eugenol modulates genomic methylation and inactivates breast cancer-associated fibroblasts through E2F1-dependent downregulation of DNMT1/DNMT3A.
Layla A Al-Kharashi, Tala Bakheet, Wejdan A AlHarbi, Nisreen Al-Moghrabi, Abdelilah Aboussekhra

Mol Carcinog· November 2021

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The potent immunomodulatory compound VGX-1027 regulates inflammatory mediators in CD4 T cells, which are concomitant with the prevention of neuroimmune dysregulation in BTBR T Itpr3/J mice.
Sheikh F Ahmad, Ahmed Nadeem, Mushtaq A Ansari, Saleh A Bakheet, Fawaz Alasmari

Life Sci· November 2019

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The DNA methyl-transferase protein DNMT1 enhances tumor-promoting properties of breast stromal fibroblasts.
Layla A Al-Kharashi, Falah H Al-Mohanna, Asma Tulbah, Abdelilah Aboussekhra

Oncotarget· January 2018

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