Publications by authors named "Lea Harrington"

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Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells.
Yahya Benslimane, Thierry Bertomeu, Jasmin Coulombe-Huntington, Mary McQuaid, María Sánchez-Osuna, David Papadopoli, Daina Avizonis, Mariana De Sa Tavares Russo, Caroline Huard, Ivan Topisirovic

September 2020

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Foundations and Strategic Vision of the Canadian Translational Geroscience Network.
Guy Hajj-Boutros, Andréa Faust, John Muscedere, Perry Kim, Gilles Gouspillou, Lea Harrington

J Gerontol A Biol Sci Med Sci· June 2025

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Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions.
Guy Hajj-Boutros, Andréa Faust, John Muscedere, Perry Kim, Naji Abumrad, Lea Harrington

J Gerontol A Biol Sci Med Sci· July 2024

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A CRISPR base editing approach for the functional assessment of telomere biology disorder-related genes in human health and aging.
Gustavo Borges, Yahya Benslimane, Lea Harrington

Biogerontology· April 2024

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No correlative evidence of costs of infection or immunity on leucocyte telomere length in a wild population of Soay sheep.
Sanjana Ravindran, Sarah L Underwood, Jennifer Dorrens, Luise A Seeker, Kathryn Watt, Lea Harrington

Proc Biol Sci· April 2024

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The association between female reproductive performance and leukocyte telomere length in wild Soay sheep.
Sanjana Ravindran, Hannah Froy, Sarah L Underwood, Jennifer Dorrens, Luise A Seeker, Lea Harrington

Mol Ecol· December 2022

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Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes.
Amanda J Stock, Ross A McDevitt, Chandrakala Puligilla, Yajun Wang, Yongqing Zhang, Lea Harrington

PLoS Genet· November 2022

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Tieing together loose ends: telomere instability in cancer and aging.
Gustavo Borges, Mélanie Criqui, Lea Harrington

Mol Oncol· September 2022

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Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes.
Zhe Jiang, Huiqin Li, Stephanie A Schroer, Veronique Voisin, YoungJun Ju, Lea Harrington

EMBO J· February 2022

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Catechin from Hook. Exhibits inhibition of human telomerase activity.
Okwuchukwu Kodichinma Eboji, Gustavo Borges, Lea Harrington, Wenhan Lin, Margaret Oluwatoyin Sofidiya

Nat Prod Res· December 2021

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CAMAP: Artificial neural networks unveil the role of codon arrangement in modulating MHC-I peptides presentation.
Tariq Daouda, Maude Dumont-Lagacé, Albert Feghaly, Yahya Benslimane, Rébecca Panes, Lea Harrington

PLoS Comput Biol· October 2021

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A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.
Yahya Benslimane, María Sánchez-Osuna, Jasmin Coulombe-Huntington, Thierry Bertomeu, Danielle Henry, Lea Harrington

Aging Cell· April 2021

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Heritable variation in telomere length predicts mortality in Soay sheep.
Hannah Froy, Sarah L Underwood, Jennifer Dorrens, Luise A Seeker, Kathryn Watt, Lea Harrington

Proc Natl Acad Sci U S A· April 2021

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Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.
Chongkui Sun, Kun Wang, Amanda J Stock, Yi Gong, Tyler G Demarest, Lea Harrington

EMBO J· November 2020

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Qualitative Changes in Cortical Thymic Epithelial Cells Drive Postpartum Thymic Regeneration.
Maude Dumont-Lagacé, Tariq Daouda, Lucyle Depoërs, Jérémie Zumer, Yahya Benslimane, Lea Harrington

Front Immunol· October 2020

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Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment.
Mélanie Criqui, Aditi Qamra, Tsz Wai Chu, Monika Sharma, Julissa Tsao, Lea Harrington

Elife· April 2020

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Editorial overview: The instability of the cancer genome: it starts at the end.
Lea Harrington, Duncan M Baird

Curr Opin Genet Dev· February 2020

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Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance.
Frances R Belmonte, Nikolaos Dedousis, Ian Sipula, Nikita A Desai, Aatur D Singhi, Lea Harrington

PLoS One· January 2020

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: unanticipated consequences of telomere dysequilibrium.
Lea Harrington, Fabio Pucci

Philos Trans R Soc Lond B Biol Sci· March 2018

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Understanding diversity in telomere dynamics.
Pat Monaghan, Dan T A Eisenberg, Lea Harrington, Dan Nussey

Philos Trans R Soc Lond B Biol Sci· March 2018

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Mammographic density, blood telomere length and lipid peroxidation.
Natalie J Erdmann, Lea A Harrington, Lisa J Martin

Sci Rep· July 2017

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Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice.
Sylvie Bannwarth, Laetitia Berg-Alonso, Gaëlle Augé, Konstantina Fragaki, Jill E Kolesar, Lea Harrington

Mitochondrion· September 2016

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Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.
Sonam Dolma, Hayden J Selvadurai, Xiaoyang Lan, Lilian Lee, Michelle Kushida, Lea Harrington

Cancer Cell· June 2016

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Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.
Craig Fraser, John C Dawson, Reece Dowling, Douglas R Houston, Jason T Weiss, Lea Harrington

J Med Chem· May 2016

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The lighthouse at the end of the chromosome.
Yahya Benslimane, Lea Harrington

F1000Res· February 2016

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