PubHawk
September 2020 PMID 32755594

Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells.

Yahya Benslimane, Thierry Bertomeu, Jasmin Coulombe-Huntington, Mary McQuaid, María Sánchez-Osuna, David Papadopoli, Daina Avizonis, Mariana De Sa Tavares Russo, Caroline Huard, Ivan Topisirovic, Hugo Wurtele, Mike Tyers, Lea Harrington

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Mentions

60
Peak: 17 in Aug 2020
across 3 sources since Aug 2020

Extended reach

830,848
potential audience

Total likes

6,530

Video views

383,042

Mentions per month

Aug 2020 – Aug 2025

Where it's discussed

  • X / Twitter55 posts
  • YouTube3 videos
  • Facebook2 posts

AI synopsis

What people are saying

The discussions encompass a variety of viewpoints, such as concerns over resveratrol's potential harm and debates regarding its activation of sirtuin-1. For instance, users reference studies indicating that resveratrol might block the benefits of exercise, using phrases like 'conflicting studies' and 'DNA-damaging agent,' which illustrate a cautious perspective on the supplement’s overall health benefits, contributing to the mixed sentiment reflected in the scores.

AgreementNeither agree nor disagree

The discussions show a mix of skepticism and support for resveratrol's effects, reflecting both disagreement and agreement within the community.

InterestModerate interest

There is moderate curiosity about the findings, with some users questioning the validity and applicability of resveratrol.

EngagementNeutral engagement

The depth of engagement varies, with some users offering critiques while others share insights about clinical studies, but overall, the conversation lacks deep analytical engagement.

ImpactModerate impact

Participants express a belief that the research has some significance, yet many also highlight contrasting findings that might undermine its applicability.

Abstract in brief

  • Resveratrol is a natural compound that may extend lifespan and has been studied for its effects on human cells.
  • Genome-wide CRISPR-Cas9 screens identified various DNA damage response genes that interact with resveratrol and similar compounds like pterostilbene.
  • The study found that resveratrol induces low-level replicative stress in cells, which affects cell growth independently of the previously assumed histone deacetylase sirtuin 1.
Read the full abstract

Top posts

Most liked on X and Bluesky
Professor Booty PhD
@ProfBootyPhD · X

Haha how did I miss this? Resveratrol is a DNA-damaging agent, has nothing to do with SIRT1. https://t.co/gcS2Aq8tDc

Mar 13, 2021 · 59 likes · 8 shares · 5,085 followers View post →
Charles Brenner, PhD
@CharlesMBrenner · X

Resveratrol & pterostilbene induce replicative stress by repressing nucleotide synthesis in a pathway that is independent of SIRT1. The dosages still are unrelated to wine but further undermine the

Oct 3, 2020 · 52 likes · 8 shares · 57,021 followers View post →
Molecular Cell
@MolecularCell · X

Online Now: Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/d6wBWnjxF1

Aug 4, 2020 · 32 likes · 11 shares · 142,712 followers View post →
Dr Brad Stanfield
@BradStanfieldMD · X

@davidasinclair @antti_antinoja Would love to have you on the channel to discuss the resveratrol research, particularly this CRISPR study: "These results establish that a primary impact of resveratrol on human cell proliferation is the induction of low-level replicative stress." https://t.co/9Ke4WliApG

Jun 4, 2021 · 24 likes · 29,158 followers View post →
Dr Brad Stanfield
@BradStanfieldMD · X

References (1/3): https://t.co/JyU7G3Htu7 https://t.co/tgLVtPCaFs https://t.co/vzAXojCwve https://t.co/G8UBt5kOmo https://t.co/qk8H3hdBnM https://t.co/sXGZkrmWZm https://t.co/k7NajEizbO https://t.co/f6Ji3E5a46

Mar 8, 2023 · 4 likes · 29,158 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells @MolecularCell https://t.co/gZgxK23Elu

Sep 4, 2020 · 3 likes · 6,435 followers View post →

All mentions

Encyc
@EncycProject · X

@ambros742 the effect of resveratrol is inconclusive, there is no consensus on its effect (https://t.co/JMXutwOgAD) and mechanistic studies have not found any correlation with sirtuin-1 (https://t.co/IglMrTiv1T) but since its safety profile is good you are probably not doing any harm

May 15, 2024 · 1 like · 9 followers View post →
styx​​ (
@styx__x · X

@D0ZER0x @MINTemplePetrus @iLoveJaneAdams @iluminatibot The research around using molecules to activate sirtuin-1 is very conflicting. We may not need to further activate sirtuin-1 if we already exercise, sleep well, and have a great diet. Its unlikely that resveratrol directly activates sirtuin-1 anyway. https://t.co/diSpjxSrer

Nov 19, 2023 · 1 like · 535 followers View post →
Nicole Laurent, LMHC
@KetoCounselor · X

Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells. (8/27) https://t.co/UGWbSOnfT7

Aug 22, 2023 · 1 like · 9,036 followers View post →
InvaderMeerkat
@invadermeerkat · X

@drkohilathas What about these though? Some studies find harm in resverstrol even with <1g dosages Resveratrol Induces Replicative Stress in Human Cells https://t.co/mx4ItMWnDb Resveratrol blunts the positive effects of exercise training on cardiovascular health https://t.co/2DxD6Qdbre

Mar 13, 2023 · 710 followers View post →
Dr Brad Stanfield
@BradStanfieldMD · X

References (1/3): https://t.co/JyU7G3Htu7 https://t.co/tgLVtPCaFs https://t.co/vzAXojCwve https://t.co/G8UBt5kOmo https://t.co/qk8H3hdBnM https://t.co/sXGZkrmWZm https://t.co/k7NajEizbO https://t.co/f6Ji3E5a46

Mar 8, 2023 · 4 likes · 29,158 followers View post →
Herman
@observeherm · X

@HOM3OSTASIS Studies showing resveratrol increases cholesterol and stresses the cell. This is not a supplement people who already are dealing with inflammation (like covid) should be taking. https://t.co/grebfih1j4 https://t.co/0RtOOnDcNp

Feb 25, 2022 · 72 followers View post →
Sebastian
@TherealWastl · X

@davidasinclair What about these studies: https://t.co/6MqTiru9w9 or https://t.co/z7ca45WhNc and https://t.co/JySuVXBiMu . Ok, the one is from 2013 and may be outdate. But one question remains: Do the positiv aspects of Resveratrol still outweigh the side effects and justify a supplementation?

Aug 13, 2021 · 1 followers View post →
Dr Brad Stanfield
@BradStanfieldMD · X

@davidasinclair @antti_antinoja Would love to have you on the channel to discuss the resveratrol research, particularly this CRISPR study: "These results establish that a primary impact of resveratrol on human cell proliferation is the induction of low-level replicative stress." https://t.co/9Ke4WliApG

Jun 4, 2021 · 24 likes · 29,158 followers View post →
Yixin(Elaine)Hu
@yixinelaineh · X

RT @CharlesMBrenner: Resveratrol & pterostilbene induce replicative stress by repressing nucleotide synthesis in a pathway that is independ…

May 20, 2021 · 8 shares · 61 followers View post →
Agingdoc
@agingdoc1 · X

An already classic study, from 2020. An equal plane for null findings are invaluable for progress. Controversies simmer for years, but science marches on. Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/dS5pBpgr2a @MolecularCell

May 9, 2021 · 2 likes · 41,432 followers View post →
RRID Robot
@RobotRrid · X

The authors of "Genome-Wide Screens Reveal that Resveratrol Induce…" (https://t.co/Bh0gHVZV2y) included RRIDs in their paper! Thank you for making your #methodsmatter. #reproducibility

May 8, 2021 · 161 followers View post →
GG
@operationoxygen · X

RT @ProfBootyPhD: Haha how did I miss this? Resveratrol is a DNA-damaging agent, has nothing to do with SIRT1. https://t.co/gcS2Aq8tDc

Mar 13, 2021 · 8 shares · 4,732 followers View post →
Benjamin E. Hardisty
@Priceeqn · X

RT @ProfBootyPhD: Haha how did I miss this? Resveratrol is a DNA-damaging agent, has nothing to do with SIRT1. https://t.co/gcS2Aq8tDc

Mar 13, 2021 · 8 shares · 922 followers View post →
VGranados
@VinicioGranados · X

RT @BarraganIP: Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells

Mar 13, 2021 · 1 share · 309 followers View post →
Lonnie R Marcum, PT, BSHCA
@LonnieRhea · X

RT @ProfBootyPhD: Haha how did I miss this? Resveratrol is a DNA-damaging agent, has nothing to do with SIRT1. https://t.co/gcS2Aq8tDc

Mar 13, 2021 · 8 shares · 3,810 followers View post →
Ben Hardisty, PhD
@TomHardyofmath · X

RT @ProfBootyPhD: Haha how did I miss this? Resveratrol is a DNA-damaging agent, has nothing to do with SIRT1. https://t.co/gcS2Aq8tDc

Mar 13, 2021 · 8 shares · 1,220 followers View post →
Michal Tal, PhD
@ImmunoFever · X

RT @ProfBootyPhD: Haha how did I miss this? Resveratrol is a DNA-damaging agent, has nothing to do with SIRT1. https://t.co/gcS2Aq8tDc

Mar 13, 2021 · 8 shares · 14,323 followers View post →
Paulino B. Iglesias
@BarraganIP · X

Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/tKuvJaV2eM

Mar 13, 2021 · 1 like · 1 share · 268 followers View post →
Prapti Mody, Ph.D.
@Papu_Sci · X

RT @ProfBootyPhD: Haha how did I miss this? Resveratrol is a DNA-damaging agent, has nothing to do with SIRT1. https://t.co/gcS2Aq8tDc

Mar 13, 2021 · 8 shares · 341 followers View post →
Mark Peifer
@peiferlabunc · X

RT @ProfBootyPhD: Haha how did I miss this? Resveratrol is a DNA-damaging agent, has nothing to do with SIRT1. https://t.co/gcS2Aq8tDc

Mar 13, 2021 · 8 shares · 11,887 followers View post →
Jason Tanny
@jason_tanny · X

RT @ProfBootyPhD: Haha how did I miss this? Resveratrol is a DNA-damaging agent, has nothing to do with SIRT1. https://t.co/gcS2Aq8tDc

Mar 13, 2021 · 8 shares · 368 followers View post →
Professor Booty PhD
@ProfBootyPhD · X

Haha how did I miss this? Resveratrol is a DNA-damaging agent, has nothing to do with SIRT1. https://t.co/gcS2Aq8tDc

Mar 13, 2021 · 59 likes · 8 shares · 5,085 followers View post →
Panos Zamanis
@pzamanis · X

RT @CharlesMBrenner: Resveratrol & pterostilbene induce replicative stress by repressing nucleotide synthesis in a pathway that is independ…

Nov 28, 2020 · 8 shares · 2,617 followers View post →
Rui
@ruixiang_tan · X

@davidasinclair @BlueZones Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells probably gonna stop RVS and switch to olive oil... https://t.co/SZQVrU7G7v

Oct 10, 2020 · 1 like · 186 followers View post →
kLee
@AndrokLee · X

RT @CharlesMBrenner: Resveratrol & pterostilbene induce replicative stress by repressing nucleotide synthesis in a pathway that is independ…

Oct 4, 2020 · 8 shares · 1,531 followers View post →
Brett Chrest
@Chrest_brett · X

RT @CharlesMBrenner: Resveratrol & pterostilbene induce replicative stress by repressing nucleotide synthesis in a pathway that is independ…

Oct 3, 2020 · 8 shares · 1,531 followers View post →
Jason Colasanti, PhD
@JasonColasanti · X

RT @CharlesMBrenner: Resveratrol & pterostilbene induce replicative stress by repressing nucleotide synthesis in a pathway that is independ…

Oct 3, 2020 · 8 shares · 1,416 followers View post →
Don Tidwell
@tidwell_don · X

RT @CharlesMBrenner: Resveratrol & pterostilbene induce replicative stress by repressing nucleotide synthesis in a pathway that is independ…

Oct 3, 2020 · 8 shares · 3,036 followers View post →
AntiAgify - Science will set you free
@AntiAgify · X

RT @CharlesMBrenner: Resveratrol & pterostilbene induce replicative stress by repressing nucleotide synthesis in a pathway that is independ…

Oct 3, 2020 · 8 shares · 1,353 followers View post →
Charles Brenner, PhD
@CharlesMBrenner · X

Resveratrol & pterostilbene induce replicative stress by repressing nucleotide synthesis in a pathway that is independent of SIRT1. The dosages still are unrelated to wine but further undermine the

Oct 3, 2020 · 52 likes · 8 shares · 57,021 followers View post →
Bartek Lab
@Bartek_Lab · X

@HanaHanzlikova @SvobodaLab https://t.co/jxVZLWeXSf

Sep 20, 2020 · 1 like · 1,146 followers View post →
Eleanor Sheekey
@EleanorSheekey · X

Covers the recent study --> Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/Sq3bz2ry3s

Sep 17, 2020 · 4,884 followers View post →
Kazuhiro Maeshima
@kazu_maeshima · X

RT @MolecularCell: Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/QsdLFlSzPa

Sep 5, 2020 · 3 shares · 1,951 followers View post →
Francis Villatoro
@emulenews · X

RT @bio_sintesis: Artículo en @MolecularCell: El resveratrol induce estrés replicativo en células humanas Genome-Wide Screens Reveal that…

Sep 5, 2020 · 2 shares · 45,127 followers View post →
मिमामसा
@scor_vir_nacci · X

RT @MolecularCell: Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/QsdLFlSzPa

Sep 4, 2020 · 3 shares · 152 followers View post →
Biosíntesis podcast
@bio_sintesis · X

Artículo en @MolecularCell: El resveratrol induce estrés replicativo en células humanas Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/8U3cMkZABS

Sep 4, 2020 · 2 likes · 2 shares · 1,254 followers View post →
z88n32
@z88n32 · X

RT @MolecularCell: Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/QsdLFlSzPa

Sep 4, 2020 · 3 shares · 28 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells @MolecularCell https://t.co/gZgxK23Elu

Sep 4, 2020 · 3 likes · 6,435 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells @MolecularCell https://t.co/gZgxK23Elu

Aug 6, 2020 · 1 like · 6,435 followers View post →
Science Socks
@SocksScience · X

RT @AgingBiology: Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/HRDKnvvP9v

Aug 5, 2020 · 2 shares · 452 followers View post →
Ulas Tezel
@TezelUlas · X

RT @MolecularCell: Online Now: Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/d6wBWnjxF1

Aug 5, 2020 · 11 shares · 539 followers View post →
Kala Nambiar, PhD MSCE
@dr_kalanambiar · X

RT @MolecularCell: Online Now: Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/d6wBWnjxF1

Aug 5, 2020 · 11 shares · 413 followers View post →
Guillermo de Cárcer
@GdC_CCCB_lab · X

RT @MolecularCell: Online Now: Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/d6wBWnjxF1

Aug 5, 2020 · 11 shares · 1,470 followers View post →
Jerome Nwachukwu
@JCnwachuk · X

RT @MolecularCell: Online Now: Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/d6wBWnjxF1

Aug 5, 2020 · 11 shares · 124 followers View post →
Kate Jiang
@kyyjiang · X

RT @MolecularCell: Online Now: Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/d6wBWnjxF1

Aug 5, 2020 · 11 shares · 131 followers View post →
Karim Mekhail
@KarimMekhail · X

RT @MolecularCell: Online Now: Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/d6wBWnjxF1

Aug 4, 2020 · 11 shares · 794 followers View post →
Amy Shaub Maddox
@AmyShaubMaddox · X

RT @MolecularCell: Online Now: Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/d6wBWnjxF1

Aug 4, 2020 · 11 shares · 1,433 followers View post →
Nutriop Longevity
@nutriop · X

Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/wNgmiw6cfT https://t.co/KWJOo0zX9C

Aug 4, 2020 · 78 followers View post →
Ivan Alfaro
@alfobioq · X

"Por el vino me quedé sin nucleótidos trifosfatos!, por el vino y no fue por SIRT": Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/coeNRYyOlF

Aug 4, 2020 · 2 likes · 820 followers View post →
Michael Buratovich
@MichaelBuratovi · X

RT @MolecularCell: Online Now: Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/d6wBWnjxF1

Aug 4, 2020 · 11 shares · 1,169 followers View post →
Lovorka Stojic
@stojic_lovorka · X

RT @MolecularCell: Online Now: Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/d6wBWnjxF1

Aug 4, 2020 · 11 shares · 2,249 followers View post →
Matt Yousefzadeh
@MattYousefzadeh · X

RT @MolecularCell: Online Now: Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/d6wBWnjxF1

Aug 4, 2020 · 11 shares · 4,772 followers View post →
Duidelik
@duidelikwatch · X

RT @MolecularCell: Online Now: Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/d6wBWnjxF1

Aug 4, 2020 · 11 shares · 95 followers View post →
Molecular Cell
@MolecularCell · X

Online Now: Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells https://t.co/d6wBWnjxF1

Aug 4, 2020 · 32 likes · 11 shares · 142,712 followers View post →
Kenta Mosallanejad
@kmosallanejad · X

Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells @MolecularCell https://t.co/8iYQb9xdRy

Aug 4, 2020 · 285 followers View post →