Publications by authors named "Lee Freiburger"

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Therapeutic Antibodies for Infectious Diseases: Recent Past, Present, and Future.
Sriram Subramaniam, James W Saville, Frank Feng, Lee Freiburger

Biochemistry· August 2025

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Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network.
Abraham Lopez, Vinay Dahiya, Florent Delhommel, Lee Freiburger, Ralf Stehle

Sci Adv· December 2021

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Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle.
Maximilian M Biebl, Abraham Lopez, Alexandra Rehn, Lee Freiburger, Jannis Lawatscheck

Nat Commun· February 2021

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A switch point in the molecular chaperone Hsp90 responding to client interaction.
Daniel Andreas Rutz, Qi Luo, Lee Freiburger, Tobias Madl, Ville R I Kaila

Nat Commun· April 2018

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A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer.
Ivan Nicola Colaluca, Andrea Basile, Lee Freiburger, Veronica D'Uva, Davide Disalvatore

J Cell Biol· February 2018

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Hsp90·Cdc37 Complexes with Protein Kinases Form Cooperatively with Multiple Distinct Interaction Sites.
Julia M Eckl, Matthias J Scherr, Lee Freiburger, Marina A Daake, Michael Sattler

J Biol Chem· December 2015

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Efficient segmental isotope labeling of multi-domain proteins using Sortase A.
Lee Freiburger, Miriam Sonntag, Janosch Hennig, Jian Li, Peijian Zou

J Biomol NMR· September 2015

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Global ITC fitting methods in studies of protein allostery.
Lee Freiburger, Karine Auclair, Anthony Mittermaier

Methods· April 2015

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A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease.
Mathias Riebold, Christian Kozany, Lee Freiburger, Michael Sattler, Michael Buchfelder

Nat Med· March 2015

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Substrate-dependent switching of the allosteric binding mechanism of a dimeric enzyme.
Lee Freiburger, Teresa Miletti, Siqi Zhu, Oliver Baettig, Albert Berghuis

Nat Chem Biol· November 2014

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Artificial accelerators of the molecular chaperone Hsp90 facilitate rate-limiting conformational transitions.
Bettina K Zierer, Matthias Weiwad, Martin Rübbelke, Lee Freiburger, Gunter Fischer

Angew Chem Int Ed Engl· November 2014

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Modulation of the Hsp90 chaperone cycle by a stringent client protein.
Oliver Robin Lorenz, Lee Freiburger, Daniel Andreas Rutz, Maike Krause, Bettina Karolina Zierer

Mol Cell· March 2014

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Van't Hoff global analyses of variable temperature isothermal titration calorimetry data.
Lee A Freiburger, Karine Auclair, Anthony K Mittermaier

Thermochim Acta· January 2012

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Collecting variable-concentration isothermal titration calorimetry datasets in order to determine binding mechanisms.
Lee A Freiburger, Anthony K Mittermaier, Karine Auclair

J Vis Exp· April 2011

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Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme.
Lee A Freiburger, Oliver M Baettig, Tara Sprules, Albert M Berghuis, Karine Auclair

Nat Struct Mol Biol· March 2011

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Elucidating protein binding mechanisms by variable-c ITC.
Lee A Freiburger, Karine Auclair, Anthony K Mittermaier

Chembiochem· December 2009

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Kinetic and structural analysis of bisubstrate inhibition of the Salmonella enterica aminoglycoside 6'-N-acetyltransferase.
Maria L B Magalhães, Matthew W Vetting, Feng Gao, Lee Freiburger, Karine Auclair

Biochemistry· January 2008

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Siloxane-supported organometallic compounds and their catalytic activities for the hydrosilylation of vinylsilanes and dienes.
Masaaki Amako, Jonathan Schinkel, Lee Freiburger, Michael A Brook

Dalton Trans· January 2005

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