Publications by authors named "Lee Josephson"

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Decoration of Autophagy Detecting Nanoparticle with an Anionic Fluorochrome Enhances Multispectral Characterization of Autophagosome Location and Flux.
Eman Akam-Baxter, Howard H Chen, Asma Boukhalfa, Ada Yu, Lauren A Ling, Lee Josephson

Small· February 2025

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Preclinical Evaluation of Novel Positron Emission Tomography (PET) Probes for Imaging Leucine-Rich Repeat Kinase 2 (LRRK2).
Zhen Chen, Jiahui Chen, Wakana Mori, Yongjia Yi, Jian Rong, Lee Josephson

J Med Chem· February 2024

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Radiochemistry for positron emission tomography.
Jian Rong, Achi Haider, Troels E Jeppesen, Lee Josephson, Steven H Liang

Nat Commun· June 2023

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Imaging Leucine-Rich Repeat Kinase 2 In Vivo with F-Labeled Positron Emission Tomography Ligand.
Zhen Chen, Jiahui Chen, Laigao Chen, Chi-Hyeon Yoo, Jian Rong, Lee Josephson

J Med Chem· February 2023

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A novel monoacylglycerol lipase-targeted F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network.
Ran Cheng, Masayuki Fujinaga, Jing Yang, Jian Rong, Achi Haider, Lee Josephson

Acta Pharmacol Sin· November 2022

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A nanoparticle probe for the imaging of autophagic flux in live mice via magnetic resonance and near-infrared fluorescence.
Howard H Chen, Zehedina Khatun, Lan Wei, Choukri Mekkaoui, Dakshesh Patel, Lee Josephson

Nat Biomed Eng· September 2022

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Preliminary evaluation of [C]MAGL-0519 as a promising PET ligand for the diagnosis of Hepatocellular carcinoma.
Tuo Shao, Zhen Chen, Ran Cheng, Lee Collier, Lee Josephson

Bioorg Chem· March 2022

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[F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models.
Tuo Shao, Zhen Chen, Jian Rong, Vasily Belov, Jiahui Chen, Lee Josephson

Acta Pharm Sin B· January 2022

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The Repertoire of Small-Molecule PET Probes for Neuroinflammation Imaging: Challenges and Opportunities beyond TSPO.
Zhen Chen, Achi Haider, Jiahui Chen, Zhiwei Xiao, Luca Gobbi, Lee Josephson

J Med Chem· December 2021

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Imaging Autotaxin with F-Labeled Positron Emission Tomography Ligands.
Xiaoyun Deng, Fernando Salgado-Polo, Tuo Shao, Zhiwei Xiao, Richard Van, Lee Josephson

J Med Chem· October 2021

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Advances in Cyclic Nucleotide Phosphodiesterase-Targeted PET Imaging and Drug Discovery.
Jiyun Sun, Zhiwei Xiao, Achi Haider, Catherine Gebhard, Hao Xu, Lee Josephson

J Med Chem· June 2021

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Development of a highly-specific F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping.
Zhen Chen, Wakana Mori, Jian Rong, Michael A Schafroth, Tuo Shao, Lee Josephson

Acta Pharm Sin B· June 2021

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Synthesis and preliminary evaluation of novel C-labeled GluN2B-selective NMDA receptor negative allosteric modulators.
Ji-Yun Sun, Katsushi Kumata, Zhen Chen, Yi-Ding Zhang, Jia-Hui Chen, Lee Josephson

Acta Pharmacol Sin· March 2021

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Evaluation of [H]CPPC as a Tool Radioligand for CSF-1R.
Ashley C Knight, Cassis Varlow, Tong Zi, Steven H Liang, Lee Josephson

ACS Chem Neurosci· March 2021

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Recent developments on PET radiotracers for TSPO and their applications in neuroimaging.
Lingling Zhang, Kuan Hu, Tuo Shao, Lu Hou, Shaojuan Zhang, Lee Josephson

Acta Pharm Sin B· February 2021

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Positron annihilation localization by nanoscale magnetization.
Yaser H Gholami, Hushan Yuan, Moses Q Wilks, Lee Josephson, Georges El Fakhri

Sci Rep· November 2020

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Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[C]methoxyphenethyl)pyridazin-3(2H)-one, a C-labeled d-amino acid oxidase (DAAO) inhibitor for PET imaging.
Xiaoyun Deng, Yiding Zhang, Zhen Chen, Katsushi Kumata, Richard Van, Lee Josephson

Bioorg Med Chem Lett· August 2020

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[F]-Alfatide PET imaging of integrin αvβ3 for the non-invasive quantification of liver fibrosis.
Tuo Shao, Zhen Chen, Vasily Belov, Xiaohong Wang, Steve H Rwema, Lee Josephson

J Hepatol· July 2020

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PET/SPECT Molecular Probes for the Diagnosis and Staging of Nonalcoholic Fatty Liver Disease.
Tuo Shao, Lee Josephson, Steven H Liang

Mol Imaging· June 2020

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A Radio-Nano-Platform for T1/T2 Dual-Mode PET-MR Imaging.
Yaser Hadi Gholami, Hushan Yuan, Moses Q Wilks, Richard Maschmeyer, Marc D Normandin, Lee Josephson

Int J Nanomedicine· June 2020

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A Chelate-Free Nano-Platform for Incorporation of Diagnostic and Therapeutic Isotopes.
Yaser H Gholami, Lee Josephson, Eman A Akam, Peter Caravan, Moses Q Wilks

Int J Nanomedicine· May 2020

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Synthesis and pharmacokinetic study of a C-labeled cholesterol 24-hydroxylase inhibitor using 'in-loop' [C]CO fixation method.
Zhen Chen, Jiahui Chen, Natalia Mast, Jian Rong, Xiaoyun Deng, Lee Josephson

Bioorg Med Chem Lett· May 2020

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Synthesis and evaluation of 6-(C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein by PET.
Qingzhen Yu, Katsushi Kumata, Hua Li, Yiding Zhang, Zhen Chen, Lee Josephson

Bioorg Med Chem Lett· February 2020

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A Novel Dual Fluorochrome Near-Infrared Imaging Probe for Potential Alzheimer's Enzyme Biomarkers-BACE1 and Cathepsin D.
Jenny M Tam, Lee Josephson, Alexander R Pilozzi, Xudong Huang

Molecules· January 2020

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Design, Synthesis, and Evaluation of F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes.
Zhen Chen, Wakana Mori, Hualong Fu, Michael A Schafroth, Akiko Hatori, Lee Josephson

J Med Chem· October 2019

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