Publications by authors named "Legen Igor"

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Predictive Potential of Acido-Basic Properties, Solubility and Food on Bioequivalence Study Outcome: Analysis of 128 Studies.
Dejan Krajcar, Rebeka Jereb, Igor Legen, Jerneja Opara, Iztok Grabnar

Drugs R D· September 2023

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Predictive Potential of BCS and Pharmacokinetic Parameters on Study Outcome: Analysis of 198 In Vivo Bioequivalence Studies.
Dejan Krajcar, Iztok Grabnar, Rebeka Jereb, Igor Legen, Jerneja Opara

Eur J Drug Metab Pharmacokinet· May 2023

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Biopharmaceutical classification of desloratadine - not all drugs are classified the easy way.
Katja Berginc, Nadica Sibinovska, Simon Žakelj, Jurij Trontelj, Igor Legen

Acta Pharm· June 2020

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The biorelevant simulation of gastric emptying and its impact on model drug dissolution and absorption kinetics.
Helena Vrbanac, Jurij Trontelj, Sandra Berglez, Boštjan Petek, Jerneja Opara, Igor Legen

Eur J Pharm Biopharm· April 2020

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In vitro-In vivo Relationship and Bioequivalence Prediction for Modified-Release Capsules Based on a PBPK Absorption Model.
Rebeka Jereb, Jerneja Opara, Igor Legen, Boštjan Petek, Darja Grabnar-Peklar

AAPS PharmSciTech· December 2019

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Physiologically based absorption modeling to predict bioequivalence of controlled release and immediate release oral products.
Amitava Mitra, Bostjan Petek, Aleksander Bajc, Raja Velagapudi, Igor Legen

Eur J Pharm Biopharm· January 2019

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PBPK Absorption Modeling of Food Effect and Bioequivalence in Fed State for Two Formulations with Crystalline and Amorphous Forms of BCS 2 Class Drug in Generic Drug Development.
Jereb Rebeka, Opara Jerneja, Legen Igor, Petek Boštjan, Bajc Aleksander

AAPS PharmSciTech· January 2019

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A Novel Intestine Model Apparatus for Drug Dissolution Capable of Simulating the Peristaltic Action.
Melita Hribar, Jurij Trontelj, Uroš Klančar, Boštjan Markun, Tanja Čeligoj Dujc, Igor Legen

AAPS PharmSciTech· July 2017

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Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Levetiracetam.
Marija Petruševska, Sandra Berglez, Igor Krisch, Igor Legen, Klara Megušar

J Pharm Sci· September 2015

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Determining the polymer threshold amount for achieving robust drug release from HPMC and HPC matrix tablets containing a high-dose BCS class I model drug: in vitro and in vivo studies.
Uroš Klančar, Saša Baumgartner, Igor Legen, Polona Smrdel, Nataša Jeraj Kampuš

AAPS PharmSciTech· April 2015

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Neuro-fuzzy models as an IVIVR tool and their applicability in generic drug development.
Jerneja Opara, Igor Legen

AAPS J· March 2014

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A novel beads-based dissolution method for the in vitro evaluation of extended release HPMC matrix tablets and the correlation with the in vivo data.
Uroš Klančar, Boštjan Markun, Saša Baumgartner, Igor Legen

AAPS J· January 2013

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Suitability of isolated rat jejunum model for demonstration of complete absorption in humans for BCS-based biowaiver request.
Luka Peternel, Katja Kristan, Marija Petruševska, Tea Lanišnik Rižner, Igor Legen

J Pharm Sci· April 2012

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Permeability of a novel beta-lactamase inhibitor LK-157 and its ester prodrugs across rat jejunum in vitro.
Petra Iglicar, Igor Legen, Gregor Vilfan, Lovro Selic, Andrej Prezelj

J Pharm Pharmacol· September 2009

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The evaluation of some pharmaceutically acceptable excipients as permeation enhancers for amoxicillin.
Igor Legen, Matjaz Kracun, Mateja Salobir, Janez Kerc

Int J Pharm· February 2006

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D-glucose triggers multidrug resistance-associated protein (MRP)-mediated secretion of fluorescein across rat jejunum in vitro.
Igor Legen, Albin Kristl

Pharm Res· April 2004

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The influence of buffer composition on tissue integrity during permeability experiments "in vitro".
Simon Zakelj, Igor Legen, Marjan Veber, Albin Kristl

Int J Pharm· March 2004

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pH and energy dependent transport of ketoprofen across rat jejunum in vitro.
Igor Legen, Albin Kristl

Eur J Pharm Biopharm· July 2003

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Factors affecting the microclimate pH of the rat jejunum in ringer bicarbonate buffer.
Igor Legen, Albin Kristl

Biol Pharm Bull· June 2003

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Ketoprofen-induced intestinal permeability changes studied in side-by-side diffusion cells.
Igor Legen, Albin Kristl

J Pharm Pharmacol· October 2002

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