Publications by authors named "Leigh Church"

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Multiplexing immunoassays for cytokine detection in the serum of patients with rheumatoid arthritis: lack of sensitivity and interference by rheumatoid factor.
Sarah M Churchman, Janina Geiler, Rekha Parmar, Elizabeth A Horner, Leigh D Church

Clin Exp Rheumatol· November 2012

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Differential cytokine secretion results from p65 and c-Rel NF-κB subunit signaling in peripheral blood mononuclear cells of TNF receptor-associated periodic syndrome patients.
Belinda Nedjai, Graham A Hitman, Leigh D Church, Kirsten Minden, Margo L Whiteford

Cell Immunol· July 2011

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Lessons from anti-TNF biologics: infliximab failure in a TRAPS family with the T50M mutation in TNFRSF1A.
Belinda Nedjai, Niamh Quillinan, Robert J Coughlan, Leigh Church, Michael F McDermott

Adv Exp Med Biol· April 2011

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Rheumatoid synovial fluid interleukin-17-producing CD4 T cells have abundant tumor necrosis factor-alpha co-expression, but little interleukin-22 and interleukin-23R expression.
Leigh D Church, Andrew D Filer, Esther Hidalgo, Katherine A Howlett, Andrew M C Thomas

Arthritis Res Ther· March 2011

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Canakinumab: a human anti-IL-1β monoclonal antibody for the treatment of cryopyrin-associated periodic syndromes.
Leigh D Church, Michael F McDermott

Expert Rev Clin Immunol· November 2010

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Linking power Doppler ultrasound to the presence of th17 cells in the rheumatoid arthritis joint.
Nicola J Gullick, Hayley G Evans, Leigh D Church, David M Jayaraj, Andrew Filer

PLoS One· September 2010

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Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes.
Laura J Dickie, Leigh D Church, Lydia R Coulthard, Rebeccah J Mathews, Paul Emery

Rheumatology (Oxford)· August 2010

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Canakinumab, a fully-human mAb against IL-1beta for the potential treatment of inflammatory disorders.
Leigh D Church, Michael F McDermott

Curr Opin Mol Ther· February 2009

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Proinflammatory action of the antiinflammatory drug infliximab in tumor necrosis factor receptor-associated periodic syndrome.
Belinda Nedjai, Graham A Hitman, Niamh Quillinan, Robert J Coughlan, Leigh Church

Arthritis Rheum· February 2009

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Rilonacept in cryopyrin-associated periodic syndromes: the beginning of longer-acting interleukin-1 antagonism.
Leigh D Church, Michael F McDermott

Nat Clin Pract Rheumatol· January 2009

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Long term management of patients with cryopyrin-associated periodic syndromes (CAPS): focus on rilonacept (IL-1 Trap).
Leigh D Church, Sinisa Savic, Michael F McDermott

Biologics· December 2008

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Prolonged, granulocyte-macrophage colony-stimulating factor-dependent, neutrophil survival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha.
Greg Parsonage, Andrew Filer, Magdalena Bik, Debbie Hardie, Sian Lax, Leigh D Church

Arthritis Res Ther· September 2008

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Primer: inflammasomes and interleukin 1beta in inflammatory disorders.
Leigh D Church, Graham P Cook, Michael F McDermott

Nat Clin Pract Rheumatol· January 2008

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Hereditary auto-inflammatory disorders and biologics.
Leigh D Church, Sarah M Churchman, Philip N Hawkins, Michael F McDermott

Springer Semin Immunopathol· June 2006

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TNFR1-induced sphingomyelinase activation modulates TCR signaling by impairing store-operated Ca2+ influx.
Leigh D Church, Gabriele Hessler, John E Goodall, David A Rider, Creg J Workman

J Leukoc Biol· July 2005

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Persistent TNF-alpha exposure impairs store operated calcium influx in CD4+ T lymphocytes.
Leigh D Church, John E Goodall, David A Rider, Paul A Bacon, Stephen P Young

FEBS Lett· February 2005

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