Publications by authors named "Leila Gobejishvili"

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Cyclic nucleotide phosphodiesterases as drug targets.
Michy P Kelly, Viacheslav O Nikolaev, Leila Gobejishvili, Claire Lugnier, Christian Hesslinger

Pharmacol Rev· May 2025

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Back to phosphodiesterase inhibitors for liver disease: Are we ready for clinical trials?
Leila Gobejishvili, Craig J McClain

Hepatology· April 2025

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Age-associated temporal decline in butyrate-producing bacteria plays a key pathogenic role in the onset and progression of neuropathology and memory deficits in 3×Tg-AD mice.
Paula M Chilton, Smita S Ghare, Benjamin T Charpentier, Scott A Myers, Aakarsha V Rao, Leila Gobejishvili

Gut Microbes· August 2024

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Association of Circulating Markers of Microbial Translocation and Hepatic Inflammation with Liver Injury in Patients with Type 2 Diabetes.
Leila Gobejishvili, Vatsalya Vatsalya, Diana V Avila, Yana B Feygin, Craig J McClain

Biomedicines· May 2024

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Hepatocyte-specific mitogen-activated protein kinase phosphatase 1 in sexual dimorphism and susceptibility to alcohol induced liver injury.
Mary Nancy Walter, Diego Montoya-Durango, Walter Rodriguez, Yali Wang, JingWen Zhang, Leila Gobejishvili

Front Immunol· February 2024

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GPR65 as a potential novel therapeutic target for the treatment of hepatic fibrosis.
Leila Gobejishvili

Mil Med Res· January 2024

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Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration.
Mohamed Elnagdy, Yali Wang, Walter Rodriguez, JingWen Zhang, Philip Bauer, Leila Gobejishvili

J Pathol· November 2023

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Dysregulated Cyclic Nucleotide Metabolism in Alcohol-Associated Steatohepatitis: Implications for Novel Targeted Therapies.
Diego Montoya-Durango, Mary Nancy Walter, Walter Rodriguez, Yali Wang, Julia H Chariker, Leila Gobejishvili

Biology (Basel)· October 2023

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Novel Liposomal Rolipram Formulation for Clinical Application to Reduce Emesis.
Leila Gobejishvili, Walter E Rodriguez, Philip Bauer, Yali Wang, Chirag Soni

Drug Des Devel Ther· May 2022

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Decrease in acetyl-CoA pathway utilizing butyrate-producing bacteria is a key pathogenic feature of alcohol-induced functional gut microbial dysbiosis and development of liver disease in mice.
Richa Singhal, Hridgandh Donde, Smita Ghare, Kendall Stocke, Jingwein Zhang, Leila Gobejishvili

Gut Microbes· December 2021

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Tributyrin Inhibits Ethanol-Induced Epigenetic Repression of CPT-1A and Attenuates Hepatic Steatosis and Injury.
Hridgandh Donde, Smita Ghare, Swati Joshi-Barve, JingWen Zhang, Manicka V Vadhanam, Leila Gobejishvili

Cell Mol Gastroenterol Hepatol· May 2021

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Correction to: Pathophysiology of Gastroparesis Syndromes Includes Anatomic and Physiologic Abnormalities.
Thomas L Abell, Archana Kedar, Abigail Stocker, Karen Beatty, Lindsay McElmurray, Leila Gobejishvili

Dig Dis Sci· May 2021

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Pathophysiology of Gastroparesis Syndromes Includes Anatomic and Physiologic Abnormalities.
Thomas L Abell, Archana Kedar, Abigail Stocker, Karen Beatty, Lindsay McElmurray, Leila Gobejishvili

Dig Dis Sci· April 2021

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Cathelicidin-related antimicrobial peptide alleviates alcoholic liver disease through inhibiting inflammasome activation.
Fengyuan Li, Cuiqing Zhao, Tuo Shao, Yunhuan Liu, Zelin Gu, Leila Gobejishvili

J Pathol· December 2020

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Elevated Fructose and Uric Acid Through Aldose Reductase Contribute to Experimental and Human Alcoholic Liver Disease.
Min Wang, Wei-Yang Chen, Jingwen Zhang, Leila Gobejishvili, Shirish S Barve

Hepatology· November 2020

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cAMP Signaling in Pathobiology of Alcohol Associated Liver Disease.
Mohamed Elnagdy, Shirish Barve, Craig McClain, Leila Gobejishvili

Biomolecules· October 2020

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Keratin 18 Is a Diagnostic and Prognostic Factor for Acute Alcoholic Hepatitis.
Vatsalya Vatsalya, Matthew C Cave, Maiying Kong, Leila Gobejishvili, K Cameron Falkner

Clin Gastroenterol Hepatol· August 2020

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Phosphodiesterase 4 Inhibition as a Therapeutic Target for Alcoholic Liver Disease: From Bedside to Bench.
Walter E Rodriguez, Banrida Wahlang, Yali Wang, Jingwen Zhang, Manicka V Vadhanam, Leila Gobejishvili

Hepatology· December 2019

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Following spinal cord injury, PDE4B drives an acute, local inflammatory response and a chronic, systemic response exacerbated by gut dysbiosis and endotoxemia.
Scott A Myers, Leila Gobejishvili, Sujata Saraswat Ohri, C Garrett Wilson, Kariena R Andres

Neurobiol Dis· April 2019

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as a Possible Risk Factor in the Development/Severity of Acute Alcoholic Hepatitis.
Yun Zhou, Vatsalya Vatsalya, Leila Gobejishvili, Richard J Lamont, Craig J McClain

Hepatol Commun· February 2019

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Urinary acrolein metabolite levels in severe acute alcoholic hepatitis patients.
Vatsalya Vatsalya, Maiying Kong, Leila Gobejishvili, Wei-Yang Chen, Sanjay Srivastava

Am J Physiol Gastrointest Liver Physiol· January 2019

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Role of cAMP and phosphodiesterase signaling in liver health and disease.
Banrida Wahlang, Craig McClain, Shirish Barve, Leila Gobejishvili

Cell Signal· September 2018

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Micro-RNA-186-5p inhibition attenuates proliferation, anchorage independent growth and invasion in metastatic prostate cancer cells.
Dominique Z Jones, M Lee Schmidt, Suman Suman, Katharine R Hobbing, Shirish S Barve, Leila Gobejishvili

BMC Cancer· April 2018

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Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation.
Diana V Avila, Scott A Myers, JingWen Zhang, Giorgi Kharebava, Craig J McClain, Leila Gobejishvili

Neuropharmacology· October 2017

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Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis.
Diana V Avila, David F Barker, JingWen Zhang, Craig J McClain, Shirish Barve, Leila Gobejishvili

J Pathol· September 2016

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