Publications by authors named "Len R Stephens"

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CDS2 expression regulates de novo phosphatidic acid synthesis.
Daniel M Collins, Vishnu Janardan, David Barneda, Karen E Anderson, Izabella Niewczas, Len R Stephens

Biochem J· October 2024

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The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signaling.
Victoria Chan, Cristina Camardi, Kai Zhang, Laura A Orofiamma, Karen E Anderson, Len R Stephens

Mol Biol Cell· September 2024

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PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate.
Tamara A M Chessa, Piotr Jung, Arqum Anwar, Sabine Suire, Karen E Anderson, Len R Stephens

Mol Cell· August 2023

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A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Grace Q Gong, Benoit Bilanges, Ben Allsop, Glenn R Masson, Victoria Roberton, Len R Stephens

Nature· June 2023

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Acyl chain selection couples the consumption and synthesis of phosphoinositides.
David Barneda, Vishnu Janardan, Izabella Niewczas, Daniel M Collins, Sabina Cosulich, Len R Stephens

EMBO J· September 2022

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The inositol 5-phosphatase INPP5B regulates B cell receptor clustering and signaling.
Alaa Droubi, Connor Wallis, Karen E Anderson, Saifur Rahman, Aloka de Sa, Len R Stephens

J Cell Biol· September 2022

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Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase.
Glenn F W Walpole, Jonathan Pacheco, Neha Chauhan, Jonathan Clark, Karen E Anderson, Len R Stephens

Nat Cell Biol· May 2022

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PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4 T Cells.
Daisy H Luff, Katarzyna Wojdyla, David Oxley, Tamara Chessa, Kevin Hudson, Len R Stephens

Front Immunol· September 2021

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Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils.
Natalie K Rynkiewicz, Karen E Anderson, Sabine Suire, Daniel M Collins, Eleftherios Karanasios, Len R Stephens

Sci Signal· November 2020

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Frontline Science: TNF-α and GM-CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K-γ, and neutrophil proinflammatory responses.
Sabine Suire, Fernando C Baltanas, Anne Segonds-Pichon, Keith Davidson, Eugenio Santos, Len R Stephens

J Leukoc Biol· October 2019

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Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy.
David Gyori, Ee Lyn Lim, Francis M Grant, Dominik Spensberger, Rahul Roychoudhuri, Len R Stephens

JCI Insight· June 2018

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PTEN Regulates PI(3,4)P Signaling Downstream of Class I PI3K.
Mouhannad Malek, Anna Kielkowska, Tamara Chessa, Karen E Anderson, David Barneda, Len R Stephens

Mol Cell· November 2017

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In-depth PtdIns(3,4,5)P signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function.
Tom N Durrant, James L Hutchinson, Kate J Heesom, Karen E Anderson, Len R Stephens

Blood Adv· June 2017

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Class (I) Phosphoinositide 3-Kinases in the Tumor Microenvironment.
David Gyori, Tamara Chessa, Phillip T Hawkins, Len R Stephens

Cancers (Basel)· March 2017

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cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity.
Ondrej Cerny, Karen E Anderson, Len R Stephens, Phillip T Hawkins, Peter Sebo

J Immunol· February 2017

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Investigating the effect of arachidonate supplementation on the phosphoinositide content of MCF10a breast epithelial cells.
Karen E Anderson, Veronique Juvin, Jonathan Clark, Len R Stephens, Phillip T Hawkins

Adv Biol Regul· September 2016

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Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8(+) T Cells.
Sarah H Ross, Christina Rollings, Karen E Anderson, Phillip T Hawkins, Len R Stephens

Immunity· September 2016

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In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling.
Simon J Bulley, Alaa Droubi, Jonathan H Clarke, Karen E Anderson, Len R Stephens

Proc Natl Acad Sci U S A· September 2016

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Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells.
Daniel M Houslay, Karen E Anderson, Tamara Chessa, Suhasini Kulkarni, Ralph Fritsch, Len R Stephens

Sci Signal· August 2016

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Emerging evidence of signalling roles for PI(3,4)P2 in Class I and II PI3K-regulated pathways.
Phillip T Hawkins, Len R Stephens

Biochem Soc Trans· February 2016

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The cytotoxic T cell proteome and its shaping by the kinase mTOR.
Jens L Hukelmann, Karen E Anderson, Linda V Sinclair, Katarzyna M Grzes, Alejandro Brenes Murillo, Len R Stephens

Nat Immunol· January 2016

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The regulatory subunits of PI3Kγ control distinct neutrophil responses.
Arnaud Deladeriere, Laure Gambardella, Dingxin Pan, Karen E Anderson, Phillip T Hawkins, Len R Stephens

Sci Signal· January 2015

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Dictyostelium uses ether-linked inositol phospholipids for intracellular signalling.
Jonathan Clark, Robert R Kay, Anna Kielkowska, Izabella Niewczas, Louise Fets, Len R Stephens

EMBO J· October 2014

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The hexosamine biosynthesis pathway and O-GlcNAcylation maintain insulin-stimulated PI3K-PKB phosphorylation and tumour cell growth after short-term glucose deprivation.
David R Jones, Willem-Jan Keune, Karen E Anderson, Len R Stephens, Phillip T Hawkins

FEBS J· August 2014

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BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737.
Danielle S Potter, Paul Kelly, Olive Denneny, Veronique Juvin, Len R Stephens

Neoplasia· February 2014

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