Publications by authors named "Lena Schultz"

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First-in-human, multicenter, open-label, phase I study of ATOR-1017 (evunzekibart), a 4-1BB antibody, in patients with advanced solid malignancies.
Ana Carneiro, Amanda Hahn, Peter Ellmark, Karin Enell Smith, Lena Schultz

J Immunother Cancer· January 2025

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ATOR-1017 (evunzekibart), an Fc-gamma receptor conditional 4-1BB agonist designed for optimal safety and efficacy, activates exhausted T cells in combination with anti-PD-1.
Karin Enell Smith, Sara Fritzell, Anneli Nilsson, Karin Barchan, Anna Rosén, Lena Schultz

Cancer Immunol Immunother· December 2023

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The Bispecific Tumor Antigen-Conditional 4-1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies.
Michelle H Nelson, Sara Fritzell, Robert Miller, Doreen Werchau, Danielle Van Citters, Lena Schultz

Mol Cancer Ther· January 2023

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A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2.
J Brian Jameson, Auric Kantz, Lena Schultz, Chakrapani Kalyanaraman, Matthew P Jacobson

PLoS One· April 2015

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Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies.
Ganesha Rai, Netra Joshi, Joo Eun Jung, Yu Liu, Lena Schultz

J Med Chem· May 2014

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Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase.
Diane K Luci, J Brian Jameson, Adam Yasgar, Giovanni Diaz, Netra Joshi, Lena Schultz

J Med Chem· January 2014

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A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.
Giang Huong Nguyen, Thomas S Dexheimer, Andrew S Rosenthal, Wai Kit Chu, Dharmendra Kumar Singh, Lena Schultz

Chem Biol· January 2013

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Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.
Victor Kenyon, Ganesha Rai, Ajit Jadhav, Lena Schultz, Michelle Armstrong

J Med Chem· August 2011

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Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay.
Stefanie Prast-Nielsen, Thomas S Dexheimer, Lena Schultz, William C Stafford, Qing Cheng

Free Radic Biol Med· May 2011

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High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.
Frank H Niesen, Lena Schultz, Ajit Jadhav, Chitra Bhatia, Kunde Guo

PLoS One· November 2010

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Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.
Ganesha Rai, Victor Kenyon, Ajit Jadhav, Lena Schultz, Michelle Armstrong

J Med Chem· October 2010

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A miniaturized screen for inhibitors of Jumonji histone demethylases.
Masaaki Sakurai, Nathan R Rose, Lena Schultz, Amy M Quinn, Ajit Jadhav

Mol Biosyst· February 2010

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