Publications by authors named "Lenka Markova"

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Crizotinib- or Ceritinib-Conjugated Platinum(IV) Prodrugs As Potent Multiaction Agents Inducing Antiproliferative Effects in 2D and 3D Cancer Cell Models.
Sofia Sharkawy, Sourav Acharya, Hana Kostrhunová, Moumita Maji, Lenka Marková

J Med Chem· November 2025

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Cisplatin-eugenol Pt(IV) prodrugs target colon cancer stem cells: A novel strategy for enhanced anticancer efficacy.
Vojtech Novohradsky, Tomer Babu, Hana Kostrhunova, Menucha Plaskow, Lenka Markova

Biomed Pharmacother· February 2025

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A Novel Substituted Benzo[]quinoxaline-Based Cyclometalated Ru(II) Complex as a Biocompatible Membrane-Targeted PDT Colon Cancer Stem Cell Agent.
Alicia Marco, Jana Kasparkova, Delia Bautista, Hana Kostrhunova, Natalia Cutillas, Lenka Markova

J Med Chem· December 2024

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Multiaction Pt(IV) Prodrugs Releasing Cisplatin and Dasatinib Are Potent Anticancer and Anti-Invasive Agents Displaying Synergism between the Two Drugs.
Lenka Markova, Moumita Maji, Hana Kostrhunova, Vojtech Novohradsky, Jana Kasparkova

J Med Chem· June 2024

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Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis.
Jana Kasparkova, Alba Hernández-García, Hana Kostrhunova, Marta Goicuría, Vojtěch Novohradsky, Lenka Markova

J Med Chem· January 2024

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Multitargeting Prodrugs that Release Oxaliplatin, Doxorubicin and Gemcitabine are Potent Inhibitors of Tumor Growth and Effective Inducers of Immunogenic Cell Death.
Amrita Sarkar, Vojtech Novohradsky, Moumita Maji, Tomer Babu, Lenka Markova

Angew Chem Int Ed Engl· October 2023

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Ir(III) Compounds Containing a Terdentate Ligand Are Potent Inhibitors of Proliferation and Effective Antimetastatic Agents in Aggressive Triple-Negative Breast Cancer Cells.
Vojtech Novohradsky, Alicia Marco, Lenka Markova, Natalia Cutillas, José Ruiz

J Med Chem· July 2023

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Platinum(IV) Derivatives of [Pt(1,2-diaminocyclohexane)(5,6-dimethyl-1,10-phenanthroline)] with Diclofenac Ligands in the Axial Positions: A New Class of Potent Multi-action Agents Exhibiting Selectivity to Cancer Cells.
Hana Kostrhunova, Brondwyn S McGhie, Lenka Markova, Olga Novakova, Jana Kasparkova

J Med Chem· June 2023

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Cyclometalated Benzimidazole Osmium(II) Complexes with Antiproliferative Activity in Cancer Cells Disrupt Calcium Homeostasis.
Alba Hernández-García, Lenka Marková, María Dolores Santana, Jitka Prachařová, Delia Bautista

Inorg Chem· April 2023

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Ruthenium(II)-Tris-pyrazolylmethane Complexes Inhibit Cancer Cell Growth by Disrupting Mitochondrial Calcium Homeostasis.
Jakub Cervinka, Alberto Gobbo, Lorenzo Biancalana, Lenka Markova, Vojtech Novohradsky

J Med Chem· August 2022

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Dipyridophenazine iridium(III) complex as a phototoxic cancer stem cell selective, mitochondria targeting agent.
Lenka Markova, Vojtech Novohradsky, Jana Kasparkova, José Ruiz, Viktor Brabec

Chem Biol Interact· June 2022

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Efficient CRISPR/Cas9-mediated gene disruption in the tetraploid protist .
Vendula Horáčková, Luboš Voleman, Kari D Hagen, Markéta Petrů, Martina Vinopalová

Open Biol· April 2022

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Gallium(III) Complex with Cloxyquin Ligands Induces Ferroptosis in Cancer Cells and Is a Potent Agent against Both Differentiated and Tumorigenic Cancer Stem Rhabdomyosarcoma Cells.
Monika Hreusova, Vojtech Novohradsky, Lenka Markova, Hana Kostrhunova, Ivan Potočňák

Bioinorg Chem Appl· April 2022

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Novel cis-Pt(II) Complexes with Alkylpyrazole Ligands: Synthesis, Characterization, and Unusual Mode of Anticancer Action.
Jana Kasparkova, Hana Kostrhunova, Vojtech Novohradsky, Аlexey A Logvinov, Viktor V Temnov, Lenka Markova

Bioinorg Chem Appl· March 2022

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A [Pt(cis-1,3-diaminocycloalkane)Cl] analog exhibits hallmarks typical of immunogenic cell death inducers in model cancer cells.
Vojtech Novohradsky, Lenka Markova, Hana Kostrhunova, Jana Kasparkova, James Hoeschele

J Inorg Biochem· January 2022

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A Cyclometalated Ir Complex Conjugated to a Coumarin Derivative Is a Potent Photodynamic Agent against Prostate Differentiated and Tumorigenic Cancer Stem Cells.
Vojtech Novohradsky, Lenka Markova, Hana Kostrhunova, Jana Kasparkova, José Ruiz

Chemistry· June 2021

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Analysis of diverse eukaryotes suggests the existence of an ancestral mitochondrial apparatus derived from the bacterial type II secretion system.
Lenka Horváthová, Vojtěch Žárský, Tomáš Pánek, Romain Derelle, Jan Pyrih

Nat Commun· May 2021

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A Multi-action Pt Conjugate with Oleate and Cinnamate Ligands Targets Human Epithelial Growth Factor Receptor HER2 in Aggressive Breast Cancer Cells.
Hana Kostrhunova, Juraj Zajac, Lenka Markova, Viktor Brabec, Jana Kasparkova

Angew Chem Int Ed Engl· November 2020

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Quantitative but Not Qualitative Performance Changes in Predictive Motor Timing as a Result of Overtraining.
Lenka Marková, Martin Bareš, Ovidiu V Lungu, Pavel Filip

Cerebellum· April 2020

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Platinum (IV) Derivatives with Cinnamate Axial Ligands as Potent Agents Against Both Differentiated and Tumorigenic Cancer Stem Rhabdomyosarcoma Cells.
Juraj Zajac, Vojtech Novohradsky, Lenka Markova, Viktor Brabec, Jana Kasparkova

Angew Chem Int Ed Engl· February 2020

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Generation of two Duchenne muscular dystrophy patient-specific induced pluripotent stem cell lines DMD02 and DMD03 (MUNIi001-A and MUNIi003-A).
Sarka Jelinkova, Lenka Markova, Martin Pesl, Iveta Valáškova, Eva Makaturová

Stem Cell Res· October 2019

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Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices post-assembly modification.
Hualong Song, Nicola J Rogers, Simon J Allison, Viktor Brabec, Hannah Bridgewater, Lenka Markova

Chem Sci· October 2019

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An anticancer Os(II) bathophenanthroline complex as a human breast cancer stem cell-selective, mammosphere potent agent that kills cells by necroptosis.
Vojtech Novohradsky, Lenka Markova, Hana Kostrhunova, Zdeněk Trávníček, Viktor Brabec

Sci Rep· September 2019

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Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated Ir Complex Conjugated to a Far-Red Emitting Coumarin.
Vojtech Novohradsky, Anna Rovira, Cormac Hally, Alex Galindo, Gloria Vigueras, Lenka Markova

Angew Chem Int Ed Engl· May 2019

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Dystrophin Deficiency Leads to Genomic Instability in Human Pluripotent Stem Cells via NO Synthase-Induced Oxidative Stress.
Sarka Jelinkova, Petr Fojtik, Aneta Kohutova, Aleksandra Vilotic, Lenka Marková

Cells· January 2019

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