Publications by authors named "Leon C D Smyth"

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Amyloidosis of bridging veins is a pathologic feature of Alzheimer's disease.
Leon C D Smyth, Daan Verhaege, Elio Standen-Bloom, Yue Wu, Yiming Gan

J Exp Med· February 2026

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Redefining CNS immune privilege.
Leon C D Smyth, Jonathan Kipnis

Nat Rev Immunol· October 2025

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Mast cells regulate the brain-dura interface and CSF dynamics.
Tornike Mamuladze, Tiago H Zaninelli, Leon C D Smyth, Yue Wu, Daviti Abramishvili

Cell· October 2025

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Cellular Contributions to Glymphatic and Lymphatic Waste Clearance in the Brain.
Leon C D Smyth, Natalie Beschorner, Maiken Nedergaard, Jonathan Kipnis

Cold Spring Harb Perspect Biol· September 2025

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The night shift: norepinephrine drives glymphatics.
Benjamin A Plog, Leon C D Smyth, Jonathan Kipnis

Cell Res· September 2025

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Correction: ADAPT-3D:accelerated deep adaptable processing of tissue for 3-dimensional fluorescence tissue imaging for research and clinical settings.
Daniel D Lee, Kevin A Telfer, Deanna L Davis, Leon C D Smyth, Rahul Ravindran

Sci Rep· September 2025

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ADAPT-3D:accelerated deep adaptable processing of tissue for 3-dimensional fluorescence tissue imaging for research and clinical settings.
Daniel D Lee, Kevin A Telfer, Deanna L Davis, Leon C D Smyth, Rahul Ravindran

Sci Rep· August 2025

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Age-related meningeal extracellular matrix remodeling compromises CNS lymphatic function.
Kate Hitpass Romero, Taylor J Stevenson, Leon C D Smyth, Ben Watkin, Samuel J C McCullough

J Neuroinflammation· April 2025

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Rest and rinse: sleeping rhythms drive brain detox.
Leon C D Smyth, Benjamin A Plog, Jonathan Kipnis

Trends Immunol· March 2025

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ADAPT-3D: Accelerated Deep Adaptable Processing of Tissue for 3-Dimensional Fluorescence Tissue Imaging for Research and Clinical Settings.
Daniel D Lee, Deanna L Davis, Leon C D Smyth, Kevin A Telfer, Rahul Ravindran

Res Sq· March 2025

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Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis.
Zachary Papadopoulos, Leon C D Smyth, Igor Smirnov, Daniel A Gibson, Jasmin Herz

J Exp Med· February 2025

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Comparing automated cell imaging with conventional methods of measuring cell proliferation and viability.
Therese Featherston, Shaya Helem, Leon C D Smyth, Mark B Hampton, Martina Paumann-Page

Toxicol Mech Methods· October 2024

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DALT: the brain's border patrol.
Jang Hyun Park, Jenolyn F Alexander, Leon C D Smyth, Jonathan Kipnis

Cell Res· September 2024

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An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination.
Kia M Barclay, Nora Abduljawad, Zuolin Cheng, Min Woo Kim, Lu Zhou, Leon C D Smyth

Immunity· June 2024

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Identification of direct connections between the dura and the brain.
Leon C D Smyth, Di Xu, Serhat V Okar, Taitea Dykstra, Justin Rustenhoven

Nature· March 2024

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Skull bone marrow channels as immune gateways to the central nervous system.
Jose A Mazzitelli, Fadi E Pulous, Leon C D Smyth, Zeynep Kaya, Justin Rustenhoven

Nat Neurosci· December 2023

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The amyotrophic lateral sclerosis-linked protein TDP-43 regulates interleukin-6 cytokine production by human brain pericytes.
Emma L Scotter, Maize C Cao, Deidre Jansson, Justin Rustenhoven, Leon C D Smyth

Mol Cell Neurosci· December 2022

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Pericytes take up and degrade α-synuclein but succumb to apoptosis under cellular stress.
Taylor J Stevenson, Rebecca H Johnson, Jimmy Savistchenko, Justin Rustenhoven, Zoe Woolf, Leon C D Smyth

Sci Rep· October 2022

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Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels.
Jose A Mazzitelli, Leon C D Smyth, Kevin A Cross, Taitea Dykstra, Jerry Sun

Nat Neurosci· May 2022

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Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer's disease.
Leon C D Smyth, Blake Highet, Deidre Jansson, Jane Wu, Justin Rustenhoven

Commun Biol· March 2022

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Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease.
Leon C D Smyth, Helen C Murray, Madison Hill, Eve van Leeuwen, Blake Highet

Acta Neuropathol Commun· March 2022

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Hypothiocyanous Acid Disrupts the Barrier Function of Brain Endothelial Cells.
Eveline van Leeuwen, Mark B Hampton, Leon C D Smyth

Antioxidants (Basel)· March 2022

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Routine culture and study of adult human brain cells from neurosurgical specimens.
Thomas I-H Park, Leon C D Smyth, Miranda Aalderink, Zoe R Woolf, Justin Rustenhoven

Nat Protoc· February 2022

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Macrophage migration inhibitory factor (MIF) enhances hypochlorous acid production in phagocytic neutrophils.
Lisa Schindler, Leon C D Smyth, Jürgen Bernhagen, Mark B Hampton, Nina Dickerhof

Redox Biol· May 2021

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Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus.
Deidre Jansson, Victor Birger Dieriks, Justin Rustenhoven, Leon C D Smyth, Emma Scotter

Commun Biol· February 2021

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