Publications by authors named "Leonidas Alexopoulos"

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Intracellular Detection of and in Non-Herniated Human Intervertebral Discs: Implications for Catabolic Signaling Pathways.
Andrea Nüesch, Exarchos Kanelis, Leonidas G Alexopoulos, Benjamin Gantenbein, Melissa Lacey

JOR Spine· December 2025

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Understanding the Physiological Behavior of Disc Cells in an In Vitro Imitation of the Healthy and Degenerated Disc Niche.
Joseph Snuggs, Shaghayegh Basatvat, Exarchos Kanelis, Abbie Binch, Leonidas Alexopoulos

JOR Spine· December 2025

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Restoration of Autophagy and Apoptosis in Myelodysplastic Syndromes: The Effect of Azacitidine in Disease Pathogenesis.
Georgia Tsekoura, Andreas Agathangelidis, Christina-Nefeli Kontandreopoulou, Eirini Sofia Fasouli, Eleni Katsantoni, Leonidas Alexopoulos

Curr Issues Mol Biol· July 2025

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TNF induces catabolism in human cartilaginous endplate cells in 3D agarose culture under dynamic compression.
Katherine B Crump, Exarchos Kanelis, Maria Segarra-Queralt, Andreu Pascuet-Fontanet, Paola Bermudez-Lekerika, Leonidas G Alexopoulos

Sci Rep· May 2025

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Ex Vivo and In Vitro Proteomic Approach to Elucidate the Relevance of IL-4 and IL-10 in Intervertebral Disc Pathophysiology.
Paola Bermudez-Lekerika, Sofia Tseranidou, Exarchos Kanelis, Andrea Nüesch, Katherine B Crump, Leonidas G Alexopoulos

JOR Spine· March 2025

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Multiplex cytokine analysis for the identification of novel potential synovial fluid biomarkers for periprosthetic joint infections.
Chrysoula Argyrou, Eftychios Papagrigorakis, Dimitrios Tzefronis, Vaia Pliaka, Christos Fotis, Leonidas Alexopoulos

Injury· August 2024

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Comparative toxicological assessment of cigarettes and new category products via an multiplex proteomics platform.
Nikos Tsolakos, Linsey E Haswell, Fabio Miazzi, Emma Bishop, Asier Antoranz, Leonidas G Alexopoulos

Toxicol Rep· June 2024

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Predicting disease severity in multiple sclerosis using multimodal data and machine learning.
Magi Andorra, Ana Freire, Irati Zubizarreta, Nicole Kerlero de Rosbo, Steffan D Bos, Leonidas G Alexopoulos

J Neurol· March 2024

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Protein kinase D drives the secretion of invasion mediators in triple-negative breast cancer cell lines.
Alexia Gali, Irene V Bijnsdorp, Sander R Piersma, Thang V Pham, Elena Gutiérrez-Galindo, Leonidas G Alexopoulos

iScience· February 2024

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Multiscale networks in multiple sclerosis.
Keith E Kennedy, Nicole Kerlero de Rosbo, Antonio Uccelli, Maria Cellerino, Federico Ivaldi, Leonidas G Alexopoulos

PLoS Comput Biol· February 2024

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Α Humanized RANKL Transgenic Mouse Model of Progestin-Induced Mammary Carcinogenesis for Evaluation of Novel Therapeutics.
Anthi Kolokotroni, Evi Gkikopoulou, Vagelis Rinotas, Lydia Ntari, Danae Zareifi, Leonidas G Alexopoulos

Cancers (Basel)· August 2023

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A Combination of Conformation-Specific RAF Inhibitors Overcome Drug Resistance Brought about by RAF Overexpression.
Hiroaki Imoto, Nora Rauch, Ashish J Neve, Fahimeh Khorsand, Martina Kreileder, Leonidas G Alexopoulos

Biomolecules· August 2023

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Targeted Proteomic Analysis of Patients with Ascending Thoracic Aortic Aneurysm.
Aphrodite Daskalopoulou, Sotiria G Giotaki, Konstantina Toli, Angeliki Minia, Vaia Pliaka, Leonidas G Alexopoulos

Biomedicines· April 2023

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Lysophosphatidic Acid Is a Proinflammatory Stimulus of Renal Tubular Epithelial Cells.
Christiana Magkrioti, Georgia Antonopoulou, Dionysios Fanidis, Vaia Pliaka, Theodore Sakellaropoulos, Leonidas G Alexopoulos

Int J Mol Sci· July 2022

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Epicardial Adipose Tissue as an Independent Cardiometabolic Risk Factor for Coronary Artery Disease.
Nikoleta Karampetsou, Leonidas Alexopoulos, Aggeliki Minia, Vaia Pliaka, Nikos Tsolakos

Cureus· June 2022

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Immuno-Modulatory Effects of Intervertebral Disc Cells.
Paola Bermudez-Lekerika, Katherine B Crump, Sofia Tseranidou, Andrea Nüesch, Exarchos Kanelis, Leonidas G Alexopoulos

Front Cell Dev Biol· June 2022

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Epicardial Adipocyte-derived TNF-α Modulates Local Inflammation in Patients with Advanced Coronary Artery Disease.
Nikoleta Karampetsou, Aspasia Tzani, Ilias P Doulamis, Evanthia Bletsa, Aggeliki Minia, Leonidas G Alexopoulos

Curr Vasc Pharmacol· May 2022

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A network-based computational and experimental framework for repurposing compounds toward the treatment of non-alcoholic fatty liver disease.
Danae Stella Zareifi, Odysseas Chaliotis, Nafsika Chala, Nikos Meimetis, Maria Sofotasiou, Leonidas G Alexopoulos

iScience· March 2022

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Regulatory network-based model to simulate the biochemical regulation of chondrocytes in healthy and osteoarthritic environments.
Maria Segarra-Queralt, Michael Neidlin, Laura Tio, Jordi Monfort, Joan Carles Monllau, Leonidas G Alexopoulos

Sci Rep· March 2022

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Stress-induced inflammation evoked by immunogenic cell death is blunted by the IRE1α kinase inhibitor KIRA6 through HSP60 targeting.
Nicole Rufo, Dimitris Korovesis, Sofie Van Eygen, Rita Derua, Abhishek D Garg, Leonidas G Alexopoulos

Cell Death Differ· January 2022

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Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis.
Insa M Schmidt, Mia R Colona, Bryan R Kestenbaum, Leonidas G Alexopoulos, Ragnar Palsson

Kidney Int· September 2021

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Prediction of combination therapies based on topological modeling of the immune signaling network in multiple sclerosis.
Marti Bernardo-Faura, Melanie Rinas, Jakob Wirbel, Inna Pertsovskaya, Vicky Pliaka, Leonidas G Alexopoulos

Genome Med· July 2021

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Accurate SARS-CoV-2 seroprevalence surveys require robust multi-antigen assays.
Christos Fotis, Nikolaos Meimetis, Nikos Tsolakos, Marianna Politou, Karolina Akinosoglou, Leonidas G Alexopoulos

Sci Rep· March 2021

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A Multi-Omics Analysis of Metastatic Melanoma Identifies a Germinal Center-Like Tumor Microenvironment in HLA-DR-Positive Tumor Areas.
Laura Gadeyne, Yannick Van Herck, Giorgia Milli, Zeynep Kalender Atak, Maddalena Maria Bolognesi, Leonidas G Alexopoulos

Front Oncol· March 2021

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Multiscale Regulation of the Intervertebral Disc: Achievements in Experimental, In Silico, and Regenerative Research.
Laura Baumgartner, Karin Wuertz-Kozak, Christine L Le Maitre, Francis Wignall, Stephen M Richardson, Leonidas G Alexopoulos

Int J Mol Sci· January 2021

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