Publications by authors named "Lesley Mitchell"

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Lymphoblasts Express Hemostatic Factors: A Mechanism for Hypercoagulability in Pediatric Acute Lymphoblastic Leukemia.
Ghada A Aborkhees, Kevin Dietrich, Amy J Barr, Lesley G Mitchell

Thromb Haemost· October 2025

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Safety and efficacy of apixaban thrombosis prevention in pediatric patients with obesity and acute lymphoblastic leukemia.
Vilmarie Rodriguez, Sarah H O'Brien, Etan Orgel, Corinna L Schultz, Adam J Esbenshade, Lesley G Mitchell

Blood Adv· September 2025

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Modeling and Simulation to Inform Apixaban Dosing in Pediatrics With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Treated With Asparaginase.
Praneeth Jarugula, Toni Ajavon-Hartmann, Obinna Obianom, Elizabeth Ludwig, Christina Crevar, Lesley G Mitchell

Clin Pharmacol Ther· August 2025

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Lessons from EINSTEIN-Jr and next steps for extended-phase anticoagulation in paediatric venous thromboembolism.
Lesley Mitchell, Vilmarie Rodriguez

Lancet Haematol· May 2025

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Dabigatran for Treatment and Secondary Prevention of Venous Thromboembolism in Pediatric Congenital Heart Disease.
Manuela Albisetti, Igor Tartakovsky, Jacqueline Halton, Lisa Bomgaars, Elizabeth Chalmers, Lesley G Mitchell

J Am Heart Assoc· February 2024

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Apixaban versus no anticoagulation for the prevention of venous thromboembolism in children with newly diagnosed acute lymphoblastic leukaemia or lymphoma (PREVAPIX-ALL): a phase 3, open-label, randomised, controlled trial.
Sarah H O'Brien, Vilmarie Rodriguez, Glen Lew, Jane W Newburger, Corinna L Schultz, Lesley G Mitchell

Lancet Haematol· January 2024

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Dabigatran in the treatment and secondary prophylaxis of venous thromboembolism in children with thrombophilia.
Leonardo R Brandão, Igor Tartakovsky, Manuela Albisetti, Jacqueline Halton, Lisa Bomgaars, Lesley G Mitchell

Blood Adv· November 2022

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Anticoagulant Effects of Dabigatran on Coagulation Laboratory Parameters in Pediatric Patients: Combined Data from Five Pediatric Clinical Trials.
Lesley G Mitchell, Daniel Röshammar, Fenglei Huang, Manuela Albisetti, Leonardo R Brandão

Thromb Haemost· September 2022

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Pharmacokinetic modeling and simulation support for age- and weight-adjusted dosing of dabigatran etexilate in children with venous thromboembolism.
Daniel Röshammar, Fenglei Huang, Manuela Albisetti, Lisa Bomgaars, Elizabeth Chalmers, Lesley G Mitchell

J Thromb Haemost· May 2021

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Dabigatran etexilate for the treatment of acute venous thromboembolism in children (DIVERSITY): a randomised, controlled, open-label, phase 2b/3, non-inferiority trial.
Jacqueline Halton, Leonardo R Brandão, Matteo Luciani, Lisa Bomgaars, Elizabeth Chalmers, Lesley G Mitchell

Lancet Haematol· January 2021

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Safety of dabigatran etexilate for the secondary prevention of venous thromboembolism in children.
Leonardo R Brandão, Manuela Albisetti, Jacqueline Halton, Lisa Bomgaars, Elizabeth Chalmers, Lesley G Mitchell

Blood· February 2020

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Predicting risk for recurrence of arterial ischemic stroke in children: thrombophilia as another piece of the puzzle.
Ghada Aborkhees, Lesley Gayle Mitchell

Haematologica· August 2019

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PREVAPIX-ALL: Apixaban Compared to Standard of Care for Prevention of Venous Thrombosis in Paediatric Acute Lymphoblastic Leukaemia (ALL)-Rationale and Design.
Sarah H O'Brien, Danshi Li, Lesley G Mitchell, Thomas Hess, Pamela Zee

Thromb Haemost· May 2019

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THROMBOTECT takes the lead.
Christoph Male, Sarah H O'Brien, Lesley Mitchell

Haematologica· April 2019

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Anticoagulant Effects of Dabigatran in Paediatric Patients Compared with Adults: Combined Data from Three Paediatric Clinical Trials.
Hugo Maas, Savion Gropper, Fenglei Huang, Joachim Stangier, Igor Tartakovsky, Lesley G Mitchell

Thromb Haemost· September 2018

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Phase 3, single-arm, multicenter study of dabigatran etexilate for secondary prevention of venous thromboembolism in children: Rationale and design.
Matteo Luciani, Manuela Albisetti, Branislav Biss, Lisa Bomgaars, Martina Brueckmann, Lesley G Mitchell

Res Pract Thromb Haemost· July 2018

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Design and rationale for the DIVERSITY study: An open-label, randomized study of dabigatran etexilate for pediatric venous thromboembolism.
Manuela Albisetti, Branislav Biss, Lisa Bomgaars, Leonardo R Brandão, Martina Brueckmann, Lesley G Mitchell

Res Pract Thromb Haemost· April 2018

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Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Dabigatran Etexilate Oral Liquid Formulation in Infants with Venous Thromboembolism.
Jacqueline M L Halton, Anne-Caroline Picard, Ruth Harper, Fenglei Huang, Martina Brueckmann, Lesley G Mitchell

Thromb Haemost· November 2017

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Design and Methods of the Pan-Canadian Applying Biomarkers to Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Nephrotoxicity Study: A Prospective Observational Cohort Study.
Kelly R McMahon, Shahrad Rod Rassekh, Kirk R Schultz, Maury Pinsk, Tom Blydt-Hansen, Lesley G Mitchell

Can J Kidney Health Dis· February 2017

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Increased plasminogen activator inhibitor results in a hypofibrinolytic state in adolescents with obesity: in vivo and ex vivo evidence.
Kevin Dietrich, Geoff D C Ball, Lesley G Mitchell

Br J Haematol· October 2016

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Age at cancer diagnosis, non-O blood group and asparaginase therapy are independently associated with deep venous thrombosis in pediatric oncology patients: A risk model.
Maria Spavor, Jacqueline Halton, Kevin Dietrich, Sara Israels, Evan Shereck, Lesley Gayle Mitchell

Thromb Res· August 2016

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Safety, tolerability and clinical pharmacology of dabigatran etexilate in adolescents. An open-label phase IIa study.
Jacqueline M L Halton, Thorsten Lehr, Lisa Cronin, Maximilian T Lobmeyer, Sebastian Haertter, Lesley G Mitchell

Thromb Haemost· August 2016

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Assessing the anticoagulant effect of dabigatran in children: an in vitro study.
Kevin Dietrich, Linda Stang, Joanne van Ryn, Lesley G Mitchell

Thromb Res· April 2015

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Increased requirement for central venous catheter replacement in paediatric oncology patients with deep venous thrombosis: a multicentre study.
Ketan Kulkarni, Jaqueline Halton, Maria Spavor, Sara J Israels, Sharon Abish, Lesley G Mitchell

Thromb Haemost· February 2015

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Evaluation of the interpretation of serial ultrasound examinations in the diagnosis of deep venous thrombosis in children: a retrospective cohort study.
Michael Stamm, Anna Zavodni, Lesley Mitchell, John Ross Bonanni, Michelle Noga

Can Assoc Radiol J· August 2014

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