Publications by authors named "Leslie B Epling"

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Discovery of INCB159020, an Orally Bioavailable KRAS G12D Inhibitor.
Qinda Ye, Artem Shvartsbart, Zhenwu Li, Pei Gan, Rocco L Policarpo, Leslie B Epling

J Med Chem· January 2025

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Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2.
Joshua R Hummel, Kai-Jiong Xiao, Jeffrey C Yang, Leslie B Epling, Ken Mukai

J Med Chem· February 2024

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Discovery of Potent and Selective Inhibitors of Wild-Type and Gatekeeper Mutant Fibroblast Growth Factor Receptor (FGFR) 2/3.
Artem Shvartsbart, Jeremy J Roach, Michael R Witten, Holly Koblish, Jennifer J Harris, Leslie B Epling

J Med Chem· November 2022

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DNA translocation mechanism of the MCM complex and implications for replication initiation.
Martin Meagher, Leslie B Epling, Eric J Enemark

Nat Commun· July 2019

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Cancer-associated mutants of RNA helicase DDX3X are defective in RNA-stimulated ATP hydrolysis.
Leslie B Epling, Christy R Grace, Brandon R Lowe, Janet F Partridge, Eric J Enemark

J Mol Biol· May 2015

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Analysis of the crystal structure of an active MCM hexamer.
Justin M Miller, Buenafe T Arachea, Leslie B Epling, Eric J Enemark

Elife· September 2014

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A conserved MCM single-stranded DNA binding element is essential for replication initiation.
Clifford A Froelich, Sukhyun Kang, Leslie B Epling, Stephen P Bell, Eric J Enemark

Elife· April 2014

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