Publications by authors named "Leslie I Grad"

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CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1) ALS mice originate from astrocytes and neurons and carry misfolded SOD1.
Judith M Silverman, Darren Christy, Chih Cheih Shyu, Kyung-Mee Moon, Sarah Fernando, Leslie I Grad

J Biol Chem· March 2019

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Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites.
Björn D M Bean, Samantha K Dziurdzik, Kathleen L Kolehmainen, Claire M S Fowler, Waldan K Kwong, Leslie I Grad

J Cell Biol· October 2018

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Intercellular Prion-Like Conversion and Transmission of Cu/Zn Superoxide Dismutase (SOD1) in Cell Culture.
Leslie I Grad, Edward Pokrishevsky, Neil R Cashman

Methods Mol Biol· May 2018

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Clinical Spectrum of Amyotrophic Lateral Sclerosis (ALS).
Leslie I Grad, Guy A Rouleau, John Ravits, Neil R Cashman

Cold Spring Harb Perspect Med· August 2017

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Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways.
Judith M Silverman, Sarah M Fernando, Leslie I Grad, Andrew F Hill, Bradley J Turner

Cell Mol Neurobiol· April 2016

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TDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashion.
Edward Pokrishevsky, Leslie I Grad, Neil R Cashman

Sci Rep· March 2016

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Exosome-dependent and independent mechanisms are involved in prion-like transmission of propagated Cu/Zn superoxide dismutase misfolding.
Leslie I Grad, Edward Pokrishevsky, Judith M Silverman, Neil R Cashman

Prion· September 2015

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From molecule to molecule and cell to cell: prion-like mechanisms in amyotrophic lateral sclerosis.
Leslie I Grad, Sarah M Fernando, Neil R Cashman

Neurobiol Dis· May 2015

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Prion-like activity of Cu/Zn superoxide dismutase: implications for amyotrophic lateral sclerosis.
Leslie I Grad, Neil R Cashman

Prion· February 2015

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Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms.
Leslie I Grad, Justin J Yerbury, Bradley J Turner, William C Guest, Edward Pokrishevsky

Proc Natl Acad Sci U S A· March 2014

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Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis.
Edward Pokrishevsky, Leslie I Grad, Masoud Yousefi, Jing Wang, Ian R Mackenzie

PLoS One· September 2012

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Generalization of the prion hypothesis to other neurodegenerative diseases: an imperfect fit.
Will C Guest, J Maxwell Silverman, Edward Pokrishevsky, Megan A O'Neill, Leslie I Grad

J Toxicol Environ Health A· December 2011

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Intermolecular transmission of superoxide dismutase 1 misfolding in living cells.
Leslie I Grad, Will C Guest, Anat Yanai, Edward Pokrishevsky, Megan A O'Neill

Proc Natl Acad Sci U S A· September 2011

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Isolation and functional analysis of mitochondria from the nematode Caenorhabditis elegans.
Leslie I Grad, Leanne C Sayles, Bernard D Lemire

Methods Mol Biol· March 2008

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Riboflavin enhances the assembly of mitochondrial cytochrome c oxidase in C. elegans NADH-ubiquinone oxidoreductase mutants.
Leslie I Grad, Bernard D Lemire

Biochim Biophys Acta· February 2006

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Introduction of an additional pathway for lactate oxidation in the treatment of lactic acidosis and mitochondrial dysfunction in Caenorhabditis elegans.
Leslie I Grad, Leanne C Sayles, Bernard D Lemire

Proc Natl Acad Sci U S A· December 2005

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Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis.
Leslie I Grad, Bernard D Lemire

Hum Mol Genet· February 2004

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