Publications by authors named "Lester Robert"

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Surfing the T Wave: A Primer on ECG T Wave Morphologies Encountered in Clinical Trials and Impact on the QT Interval and Patient Safety.
Robert M Lester, Sabina Paglialunga

Clin Transl Sci· March 2025

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Should You Run a Dedicated TQT Study? Sponsor and Regulatory Considerations on Substitution Pathways to Assess QT Liability.
Robert M Lester, Caroline Engel, Aernout D van Haarst, Sabina Paglialunga

Clin Pharmacol Ther· July 2024

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Prevalence of Baseline Cardiac Arrhythmias in Participants with Overweight or Obesity in Phase 1 Clinical Trials: Analysis of 24-Hour Holter Electrocardiogram Recordings.
Dorthe Skovgaard, Poul-Martin Haahr, Robert Lester, Katherine Clark, Sabina Paglialunga

J Clin Pharmacol· May 2023

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Effect of Futibatinib on Cardiac Repolarization: Results of a Randomized, Controlled, Double-Blind, QT/QTc, Phase 1 Study in Healthy Subjects.
Ikuo Yamamiya, Robert Lester, Daryl Sonnichsen, Mark Mina, Yaohua He

Clin Pharmacol Drug Dev· March 2023

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A Randomized, Double-Blind, Parallel Design Thorough QT Study With a Nested Crossover to Compare the Cardiac Safety of Amiselimod With Placebo and Positive Control in Healthy Volunteers.
Jimin Lee, Robert Lester, Terry O'Reilly, Ezra R Lowe, Neal E Slatkin, Robert J Israel

Clin Pharmacol Drug Dev· March 2023

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P029 Pharmacokinetic/Pharmacodynamic Analysis of Amiselimod, a Selective Sphingosine 1-Phosphate Receptor Modulator, in Healthy Subjects: Results From a Phase 1 Study.
Jimin Lee, Robert Lester, Terry O'Reilly, Ezra Lowe, Neal Slatkin, Robert Israel

Am J Gastroenterol· December 2021

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Update on ICH E14/S7B Cardiac Safety Regulations: The Expanded Role of Preclinical Assays and the "Double-Negative" Scenario.
Robert M Lester

Clin Pharmacol Drug Dev· September 2021

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P014 Analysis of QT Interval Prolongation of Amiselimod in Healthy Subjects: A Phase 1 Randomized Controlled Trial.
Hanauer Stephen, O'Reilly Terry, Lester Robert, Slatkin Neal, Lee Jimin, Israel Robert

Am J Gastroenterol· December 2020

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Safety, Tolerability, Pharmacokinetics, and Concentration-QTc Analysis of Tetrodotoxin: A Randomized, Dose Escalation Study in Healthy Adults.
Mojgan Kavoosi, Terry E O'Reilly, Mehran Kavoosi, Peng Chai, Caroline Engel, Robert M Lester

Toxins (Basel)· August 2020

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Prediction of thigh skeletal muscle mass using dual energy x-ray absorptiometry compared to magnetic resonance imaging after spinal cord injury.
Robert M Lester, Mina P Ghatas, Rehan M Khan, Ashraf S Gorgey

J Spinal Cord Med· September 2019

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Dietary manipulation and testosterone replacement therapy may explain changes in body composition after spinal cord injury: A retrospective case report.
Ashraf S Gorgey, Robert M Lester, Mina P Ghatas, Sakita N Sistrun, Timothy Lavis

World J Clin Cases· September 2019

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QT Assessment in Early Drug Development: The Long and the Short of It.
Robert M Lester, Sabina Paglialunga, Ian A Johnson

Int J Mol Sci· March 2019

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Semi-automated segmentation of magnetic resonance images for thigh skeletal muscle and fat using threshold technique after spinal cord injury.
Mina P Ghatas, Robert M Lester, M Rehan Khan, Ashraf S Gorgey

Neural Regen Res· October 2018

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Validation of Anthropometric Muscle Cross-Sectional Area Equation after Spinal Cord Injury.
Rodney C Wade, Robert M Lester, Ashraf S Gorgey

Int J Sports Med· May 2018

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Evaluating cardiac risk: exposure response analysis in early clinical drug development.
Julie Grenier, Sabina Paglialunga, Bruce H Morimoto, Robert M Lester

Drug Healthc Patient Saf· April 2018

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Feasibility of robotic exoskeleton ambulation in a C4 person with incomplete spinal cord injury: a case report.
Robert M Lester, Ashraf S Gorgey

Spinal Cord Ser Cases· April 2018

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Paradigms of Lower Extremity Electrical Stimulation Training After Spinal Cord Injury.
Ashraf S Gorgey, Refka E Khalil, Robert M Lester, Gary A Dudley, David R Gater

J Vis Exp· February 2018

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Quantification of intermuscular and intramuscular adipose tissue using magnetic resonance imaging after neurodegenerative disorders.
Madoka Ogawa, Robert Lester, Hiroshi Akima, Ashraf S Gorgey

Neural Regen Res· December 2017

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A feasibility pilot using telehealth videoconference monitoring of home-based NMES resistance training in persons with spinal cord injury.
Ashraf S Gorgey, Robert M Lester, Rodney C Wade, Refka E Khalil, Rehan K Khan

Spinal Cord Ser Cases· June 2017

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MRI analysis and clinical significance of lower extremity muscle cross-sectional area after spinal cord injury.
Robert M Lester, Kori Johnson, Refka E Khalil, Rehan Khan, Ashraf S Gorgey

Neural Regen Res· May 2017

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Early drug development: assessment of proarrhythmic risk and cardiovascular safety.
Robert M Lester, Joy Olbertz

Expert Rev Clin Pharmacol· December 2016

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Age-related changes in perception of movement in driving scenes.
Philippe Lacherez, Laura Turner, Robert Lester, Zoe Burns, Joanne M Wood

Ophthalmic Physiol Opt· July 2014

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Iron, glucose and intrinsic factors alter sphingolipid composition as yeast cells enter stationary phase.
Robert L Lester, Bradley R Withers, Megan A Schultz, Robert C Dickson

Biochim Biophys Acta· April 2013

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Turbellarian black spot disease in bluespine unicornfish Naso unicornis in New Caledonia, caused by the parasitic turbellarian Piscinquilinus sp.
Jean-Lou Justine, Philippe Leblanc, Florent Keller, Robert J G Lester

Dis Aquat Organ· July 2009

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SVF1 regulates cell survival by affecting sphingolipid metabolism in Saccharomyces cerevisiae.
Jennifer L Brace, Robert L Lester, Robert C Dickson, Charles M Rudin

Genetics· January 2007

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