Publications by authors named "Letian Song"

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Miniaturized Modular Click Chemistry-enabled Rapid Discovery of Unique SARS-CoV-2 M Inhibitors With Robust Potency and Drug-like Profile.
Mianling Yang, Myoung Kyu Lee, Shenghua Gao, Letian Song, Hye-Yeon Jang

Adv Sci (Weinh)· November 2024

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Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 M inhibitors with improved metabolic stability.
Shenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li

RSC Med Chem· October 2024

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[Not Available].
Letian Song, Shenghua Gao, Bing Ye, Mianling Yang, Yusen Cheng

Acta Pharm Sin B· January 2024

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Design, Synthesis, and Biological Evaluation of Trisubstituted Piperazine Derivatives as Noncovalent Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors with Improved Antiviral Activity and Favorable Druggability.
Shenghua Gao, Letian Song, Katharina Sylvester, Beatrice Mercorelli, Arianna Loregian

J Med Chem· December 2023

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Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles.
Shenghua Gao, Letian Song, Yusen Cheng, Fabao Zhao, Dongwei Kang, Shu Song

Acta Pharm Sin B· June 2023

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Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors.
Shenghua Gao, Letian Song, Tobias Claff, Molly Woodson, Katharina Sylvester

J Med Chem· December 2022

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Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors.
Shenghua Gao, Letian Song, Hongtao Xu, Antonios Fikatas, Merel Oeyen

Molecules· December 2022

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Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity.
Shenghua Gao, Katharina Sylvester, Letian Song, Tobias Claff, Lanlan Jing

J Med Chem· October 2022

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Chemical space exploration around indolylarylsulfone scaffold led to a novel class of highly active HIV-1 NNRTIs with spiro structural features.
Shenghua Gao, Yusen Cheng, Shu Song, Letian Song, Fabao Zhao

Eur J Med Chem· August 2022

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Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors.
Shenghua Gao, Tianguang Huang, Letian Song, Shujing Xu, Yusen Cheng

Acta Pharm Sin B· February 2022

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Phylogenetic Analysis of Protein Family.
Letian Song, Sherry Wu, Adrian Tsang

Methods Mol Biol· February 2019

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Efficient genome editing using tRNA promoter-driven CRISPR/Cas9 gRNA in Aspergillus niger.
Letian Song, Jean-Paul Ouedraogo, Magdalena Kolbusz, Thi Truc Minh Nguyen, Adrian Tsang

PLoS One· February 2019

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Engineering a thermostable fungal GH10 xylanase, importance of N-terminal amino acids.
Letian Song, Adrian Tsang, Michel Sylvestre

Biotechnol Bioeng· June 2015

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Impact of an N-terminal extension on the stability and activity of the GH11 xylanase from Thermobacillus xylanilyticus.
Letian Song, Claire Dumon, Béatrice Siguier, Isabelle André, Elena Eneyskaya

J Biotechnol· March 2014

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Engineering better biomass-degrading ability into a GH11 xylanase using a directed evolution strategy.
Letian Song, Béatrice Siguier, Claire Dumon, Sophie Bozonnet, Michael J O'Donohue

Biotechnol Biofuels· January 2012

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A high-throughput screening system for the evaluation of biomass-hydrolyzing glycoside hydrolases.
Letian Song, Sandrine Laguerre, Claire Dumon, Sophie Bozonnet, Michael J O'Donohue

Bioresour Technol· November 2010

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Effect and limitation of excess ammonium on the release of O-glycans in reducing forms from glycoproteins under mild alkaline conditions for glycomic and functional analysis.
Guangli Yu, Yibing Zhang, Zhenqing Zhang, Letian Song, Peipei Wang

Anal Chem· November 2010

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[
[Behaviors of beta-glucan from Grifola frondosa in high performance gel permeation chromatography].
Letian Song, Guangli Yu, Xia Zhao, Haodong Gao, Xiaohua Yang

Se Pu· May 2007

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