Publications by authors named "Liam Simms"

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Assessment of heated herbal products' tobacco harm reduction potential: pre-clinical and clinical studies.
Alvaro-Flavio Marinas-Lacasta, Ian M Fearon, Matthew Stevenson, Tasnim Abusalem, Fiona Chapman, Liam Simms

Front Toxicol· September 2025

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Corrigendum: Applying new approach methodologies to assess next-generation tobacco and nicotine products.
David Thorne, Damian McHugh, Liam Simms, K Monica Lee, Hitoshi Fujimoto

Front Toxicol· July 2024

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Optimisation of an human cardiovascular model on-a-chip for toxicological assessment of nicotine delivery products.
Fiona Chapman, Luuk de Haan, Linda Gijzen, Wouter Strijker, Edgar Trelles Sticken, Liam Simms

Front Toxicol· June 2024

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Applying new approach methodologies to assess next-generation tobacco and nicotine products.
David Thorne, Damian McHugh, Liam Simms, K Monica Lee, Hitoshi Fujimoto

Front Toxicol· June 2024

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The Product Science of Electrically Heated Tobacco Products: An Updated Narrative Review of the Scientific Literature.
Sarah Cordery, Keith Thompson, Matthew Stevenson, Liam Simms, Fiona Chapman

Cureus· May 2024

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Use of quantitative to extrapolation (QIVIVE) for the assessment of non-combustible next-generation product aerosols.
Marjory Moreau, Liam Simms, Melvin E Andersen, Edgar Trelles Sticken, Roman Wieczorek

Front Toxicol· April 2024

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Key challenges for in vitro testing of tobacco products for regulatory applications: Recommendations for dosimetry.
Jacqueline Miller-Holt, Holger Behrsing, Ian Crooks, Rodger Curren, Kubilay Demir, Liam Simms

Drug Test Anal· October 2023

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Characterisation of a smoke/ aerosol exposure in vitro system (SAEIVS) for delivery of complex mixtures directly to cells at the air-liquid interface.
Roman Wieczorek, Edgar Trelles Sticken, Sarah Jean Pour, Fiona Chapman, Karin Röwer, Liam Simms

J Appl Toxicol· July 2023

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Multiple endpoint in vitro toxicity assessment of a prototype heated tobacco product indicates substantially reduced effects compared to those of combustible cigarette.
Fiona Chapman, Edgar Trelles Sticken, Roman Wieczorek, Sarah Jean Pour, Ole Dethloff, Liam Simms

Toxicol In Vitro· February 2023

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Twenty-eight day repeated exposure of human 3D bronchial epithelial model to heated tobacco aerosols indicates decreased toxicological responses compared to cigarette smoke.
Fiona Chapman, Sarah Jean Pour, Roman Wieczorek, Edgar Trelles Sticken, Jessica Budde, Liam Simms

Front Toxicol· February 2023

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Key Challenges and Recommendations for Testing of Tobacco Products for Regulatory Applications: Consideration of Test Materials and Exposure Parameters.
Martha M Moore, Irene Abraham, Mark Ballantyne, Holger Behrsing, Xuefei Cao, Liam Simms

Altern Lab Anim· January 2023

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Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Predict the Cardiotoxicity Potential of Next Generation Nicotine Products.
Liam Simms, Fan Yu, Jessica Palmer, Kathryn Rudd, Edgar Trelles Sticken

Front Toxicol· February 2022

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Use of a rapid human primary cell-based disease screening model, to compare next generation products to combustible cigarettes.
Liam Simms, Elizabeth Mason, Ellen L Berg, Fan Yu, Kathryn Rudd

Curr Res Toxicol· August 2021

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The in vitro ToxTracker and Aneugen Clastogen Evaluation extension assay as a tool in the assessment of relative genotoxic potential of e-liquids and their aerosols.
Lukasz Czekala, Fiona Chapman, Liam Simms, Kathryn Rudd, Edgar Trelles Sticken

Mutagenesis· May 2021

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Multi-endpoint analysis of human 3D airway epithelium following repeated exposure to whole electronic vapor product aerosol or cigarette smoke.
Lukasz Czekala, Roman Wieczorek, Liam Simms, Fan Yu, Jessica Budde

Curr Res Toxicol· February 2021

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The use of human induced pluripotent stem cells to screen for developmental toxicity potential indicates reduced potential for non-combusted products, when compared to cigarettes.
Liam Simms, Kathryn Rudd, Jessica Palmer, Lukasz Czekala, Fan Yu

Curr Res Toxicol· June 2020

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High Content Screening in NHBE cells shows significantly reduced biological activity of flavoured e-liquids, when compared to cigarette smoke condensate.
Lukasz Czekala, Liam Simms, Matthew Stevenson, Edgar Trelles-Sticken, Paul Walker

Toxicol In Vitro· August 2019

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Assessment of priority tobacco additives per the requirements of the EU Tobacco Products Directive (2014/40/EU): Part 1: Background, approach, and summary of findings.
Liam Simms, Anna Clarke, Thilo Paschke, Andrew Manson, James Murphy

Regul Toxicol Pharmacol· June 2019

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Assessment of priority tobacco additives per the requirements of the EU Tobacco Products Directive (2014/40/EU): Part 3, Smoking behavior and plasma nicotine pharmacokinetics.
Michael McEwan, Steven Coburn, David Ghosh, Liam Simms, Lesley Giles

Regul Toxicol Pharmacol· June 2019

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The use of Genomic Allergen Rapid Detection (GARD) assays to predict the respiratory and skin sensitising potential of e-liquids.
Matthew Stevenson, Lukasz Czekala, Liam Simms, Nicole Tschierske, Olivia Larne

Regul Toxicol Pharmacol· April 2019

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Toxicological comparison of cigarette smoke and e-cigarette aerosol using a 3D in vitro human respiratory model.
Lukasz Czekala, Liam Simms, Matthew Stevenson, Nicole Tschierske, Anna G Maione

Regul Toxicol Pharmacol· April 2019

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