Publications by authors named "Ligen Lin"

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Fat-targeted small molecule alleviates abnormal adipose tissue remodeling in obesity via SIRT3-driven mitophagy and inflammasome inhibition.
Kegang Linghu, Longkun Hu, Yu-E Wang, Yuxia Zhou, Yuanyuan Wang, Ligen Lin

Chin Med· December 2025

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Bioactivity-based molecular networking-guided identification of methyl rosmarinate from Orthosiphon aristatus as a PTP1B inhibitor that improves insulin sensitivity in diabetic mice.
Bojun Xie, Dafu Zhu, Linxuan Li, Ruohan Lou, Rui Wang, Ligen Lin

Phytomedicine· November 2025

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Computer assisted discovery of novel nicotinamide phosphoribosyltransferase agonists to combat muscle atrophy.
Linxuan Li, Ruifeng Wang, Jianzhong Zhu, Fangqi Cao, Jingli Min, Ligen Lin

Bioorg Chem· November 2025

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Dimeric guaianolide sesquiterpenoids from the flowers of Chrysanthemum indicum ameliorate hepatic steatosis through mitigating SIRT1-mediated lipid accumulation and ferroptosis.
Yu Liu, Fei Zhou, Haoyu Zhao, Jianguo Song, Min Song, Ligen Lin

J Adv Res· October 2025

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4-Vinylguaiacol in Citri Reticulatae 'Chachiensis' Pericarpium Volatile Oil: A Microbial-Mediated Aging Marker Enhances Glucose Metabolism.
Hao Zheng, Zhi-Cheng Su, Shu-Ting Huang, Dong-Li Li, Zhao-Dong Yuan, Li-Gen Lin

Foods· October 2025

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Lactucin enhances glucose uptake and glycolysis in C2C12 myotubes by activating AMPK signaling pathway.
Hao Zheng, Kaiwen Kang, Yujia Zhang, Ligen Lin, Lishe Gan

Nat Prod Res· September 2025

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Xerophenone H, a naturally-derived proteasome inhibitor, triggers apoptosis and paraptosis in lung cancer.
Wen-Yu Lyu, Jun Cao, Wei-Qing Deng, Mu-Yang Huang, Hongwei Guo, Li-Gen Lin

Phytomedicine· June 2025

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Monocyclic and polycyclic polyprenylated acylphloroglucinols with anti-steatohepatitis effect from the pericarps of Garcinia multiflora.
Huijuan Luo, Jun Cao, Yujia Zhang, Hao Dou, Xu Liang, Zheling Feng, Ligen Lin

Fitoterapia· June 2025

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Adipocyte-expressed SIRT3 manipulates carnitine pool to orchestrate metabolic reprogramming and polarization of macrophages.
Jiali Chen, Fei Zhou, Lei Zhang, Ruohan Lou, Cangman Zhang, Ligen Lin

Cell Death Dis· May 2025

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Polycyclic polyprenylated acylphloroglucinols from the pericarps of Garcinia multiflora champ. ex Benth. with cytotoxic property.
Jun Cao, Wen-Yu Lyu, Yujia Zhang, Zhicheng Su, Ting Li, Ligen Lin

Phytochemistry· December 2024

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Anti-inflammatory bicyclic polyprenylated acylphloroglucinols with diverse architectures including an unprecedented 6/6/6 tricyclic core from Garcinia yunnanensis.
Xin-Yue Hu, Hui-Juan Luo, Xin Wei, Yu-Zhuo Wang, Yan-Song Ye, Li-Gen Lin

Bioorg Chem· December 2024

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Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke.
Ru Li, Riqing Wei, Chenxin Liu, Keying Zhang, Sixiao He, Ligen Lin

Acta Pharm Sin B· September 2024

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Small molecule -methylene--butyrolactone, an evolutionarily conserved moiety in sesquiterpene lactones, ameliorates arthritic phenotype interference DNA binding activity of NF-B.
Kegang Linghu, Wenqing Cui, Taiqin Li, Yueting Tuo, Dasong Wang, Ligen Lin

Acta Pharm Sin B· August 2024

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Myricanol prevents aging-related sarcopenia by rescuing mitochondrial dysfunction via targeting peroxiredoxin 5.
Shengnan Shen, Qiwen Liao, Peng Lyu, Jigang Wang, Ligen Lin

MedComm (2020)· June 2024

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Limonoids from the roots of Melia azedarach and their anti-inflammatory activity.
Min Song, Hui-Juan Luo, Zi-Wei Li, Ling Qiu, Yu-Xin Zhao, Li-Gen Lin

Phytochemistry· December 2023

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Exosomal miRNA-155-5p from M1-polarized macrophages suppresses angiogenesis by targeting GDF6 to interrupt diabetic wound healing.
Ruohan Lou, Jiali Chen, Fei Zhou, Tian Zhang, Xiuping Chen, Ligen Lin

Mol Ther Nucleic Acids· December 2023

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Germacrane-type sesquiterpenoids from the flowers of Chrysanthemum indicum with hepatoprotective activity.
Yu Liu, Fei Zhou, Hong-Zhen Shu, Li-Gen Lin, Qing-Wen Zhang

Food Chem Toxicol· July 2023

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Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction.
Qingwen Xiao, Bingling Zhong, Ying Hou, Miaojuan Wang, Baojian Guo, Ligen Lin

Free Radic Biol Med· June 2023

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Bisabolane-Type Sesquiterpenoids with a Tetrahydrofuran or Tetrahydropyran Ring from .
Zeng Li, Yue Yang, Cheng Chen, Ligen Lin, Chunping Tang

J Nat Prod· June 2023

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Affinity-based protein profiling-driven discovery of myricanol as a Nampt activator.
Peng Lyu, Shengrong Li, Ying Han, Shengnan Shen, Zheling Feng, Ligen Lin

Bioorg Chem· April 2023

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Simple Nano-Luciferase-Based Assay for the Rapid and High-Throughput Detection of SARS-CoV-2 3C-Like Protease.
Jingxin Liu, Chenchen Ge, Ling Zha, Ligen Lin, Rongsong Li

Anal Chem· January 2023

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Lipophagy: Molecular Mechanisms and Implications in Hepatic Lipid Metabolism.
Sai Feng, Zeao Sun, Xiao Jia, Lingyun Li, Yijian Wu, Ligen Lin

Front Biosci (Landmark Ed)· January 2023

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Comparison of and var. from Different Origins Based on Multi-Component Quantification and Anticancer Activity.
Min-Hui Chen, Fong Leong, Si-Jia Gao, Xin Chen, Jin-Jian Lu, Li-Gen Lin

Molecules· January 2023

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Sirtuins: Key players in obesity-associated adipose tissue remodeling.
Jiali Chen, Ruohan Lou, Fei Zhou, Dan Li, Cheng Peng, Ligen Lin

Front Immunol· December 2022

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Chantriolides F-P, Highly Oxidized Withanolides with Hepatoprotective Activity from .
Yue Yang, Fei Zhou, Min Wang, Mukhammadrizo Turanazarov, Xiao-Rong Wang, Ligen Lin

Molecules· November 2022

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