Publications by authors named "Liling Wan"

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RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription.
Krista A Budinich, Xinyi Yao, Chujie Gong, Lele Song, Xiaoting Wang, Liling Wan

bioRxiv· November 2025

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Editor's Note: Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia.
Yiman Liu, Qinglan Li, Fatemeh Alikarami, Declan R Barrett, Leila Mahdavi, Liling Wan

Cancer Discov· June 2025

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Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression.
Yiman Liu, Qinglan Li, Lele Song, Chujie Gong, Sylvia Tang, Liling Wan

Cancer Discov· August 2024

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Single-cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape.
Lele Song, Qinglan Li, Lingbo Xia, Arushi Eesha Sahay, Qi Qiu, Liling Wan

Nat Commun· July 2024

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Dysregulation of transcriptional condensates in human disease: mechanisms, biological functions, and open questions.
Kaeli M Mathias, Yiman Liu, Liling Wan

Curr Opin Genet Dev· June 2024

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Single-Cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape.
Lele Song, Qinglan Li, Lingbo Xia, Arushi Sahay, Qi Qiu, Liling Wan

bioRxiv· May 2024

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Lead Optimization of Small Molecule ENL YEATS Inhibitors to Enable Studies: Discovery of TDI-11055.
Mayako Michino, Tanweer A Khan, Michael W Miller, Yoshiyuki Fukase, Jeremie Vendome, Liling Wan

ACS Med Chem Lett· April 2024

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DLBCL-associated NOTCH2 mutations escape ubiquitin-dependent degradation and promote chemoresistance.
Nan Zhou, Jaewoo Choi, Grant Grothusen, Bang-Jin Kim, Diqiu Ren, Liling Wan

Blood· September 2023

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p53 restoration in small cell lung cancer identifies a latent cyclophilin-dependent necrosis mechanism.
Jonuelle Acosta, Qinglan Li, Nelson F Freeburg, Nivitha Murali, Alexandra Indeglia, Liling Wan

Nat Commun· July 2023

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Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia.
Xue Qing David Wang, Dandan Fan, Qinyu Han, Yiman Liu, Hongzhi Miao, Xinyu Wang, Liling Wan

Cancer Discov· March 2023

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Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia.
Yiman Liu, Qinglan Li, Fatemeh Alikarami, Declan R Barrett, Leila Mahdavi, Liling Wan

Cancer Discov· November 2022

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Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer.
Lele Song, Xinyi Yao, Hangpeng Li, Bo Peng, Alan P Boka, Liling Wan

Mol Cell· November 2022

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KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs.
Fangxue Yan, Jinyang Li, Jelena Milosevic, Ricardo Petroni, Suying Liu, Liling Wan

Cancer Discov· March 2022

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Efficacy and Safety of Re Du Ning Injection for Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.
Bofei Shu, Hong Li, Xu Zhou, Zhaohui Ding, Liling Wan

Evid Based Complement Alternat Med· March 2022

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Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis.
Minhong Shen, Yong Wei, Hahn Kim, Liling Wan, Yi-Zhou Jiang

Nat Cancer· January 2022

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Pharmacological disruption of the MTDH-SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer.
Minhong Shen, Heath A Smith, Yong Wei, Yi-Zhou Jiang, Sheng Zhao, Nicole Wang, Liling Wan

Nat Cancer· January 2022

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Challenges and opportunities in 2021.
Leila Akkari, Stacey D Finley, Ping-Chih Ho, Misty Jenkins, Barbara B Maier, Liling Wan

Nat Cancer· December 2021

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Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis.
Minhong Shen, Shanshan Xie, Michelle Rowicki, Sven Michel, Yong Wei, Liling Wan

Cancer Res· February 2021

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Impaired cell fate through gain-of-function mutations in a chromatin reader.
Liling Wan, Shasha Chong, Fan Xuan, Angela Liang, Xiaodong Cui, Shu-Ping Wang, Xiaolu Wang

Nature· January 2020

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Structure-guided development of YEATS domain inhibitors by targeting π-π-π stacking.
Xin Li, Xiao-Meng Li, Yixiang Jiang, Zheng Liu, Yiwen Cui, Liling Wan

Nat Chem Biol· December 2018

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[Effect of ear point embedding on plasma and effect site concentrations of propofol-remifentanil in elderly patients after target-controlled induction].
Xiaochun Zheng, Liling Wan, Fei Gao, Jianghu Chen, Wenshao Tu

Zhongguo Zhen Jiu· August 2017

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ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia.
Liling Wan, Hong Wen, Yuanyuan Li, Jie Lyu, Yuanxin Xi, Xiaolu Wang

Nature· March 2017

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Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain.
Yuanyuan Li, Benjamin R Sabari, Tatyana Panchenko, Hong Wen, Dan Zhao, Liling Wan

Mol Cell· April 2016

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[Treatment of Mild-to-moderate Bronchial Asthma (Heat Wheezing Syndrome) Patients at Acute Onset with Western Medicine Combined Danlong Oral Liquid: a Multi-center, Randomized Double- blinded, Positive-controlled Clinical Trial].
Min Liu, Gui-ying Liu, Si-yuan Hu, Li-ling Wan, Hong-yan Cai

Zhongguo Zhong Xi Yi Jie He Za Zhi· May 2015

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Structural insights into the tumor-promoting function of the MTDH-SND1 complex.
Feng Guo, Liling Wan, Aiping Zheng, Vitali Stanevich, Yong Wei

Cell Rep· September 2014

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