Publications by authors named "Line Ledsgaard"

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Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies using light-chain shuffling.
Tulika Tulika, Fulgencio Ruso-Julve, Shirin Ahmadi, Anne Ljungars, Esperanza Rivera-de-Torre, Line Ledsgaard

Structure· September 2024

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Genomic Analysis of Section Reveals a High Potential in Secondary Metabolite Production and Plant Biomass Degradation.
Sebastian Theobald, Tammi C Vesth, Elena Geib, Jane L Nybo, Jens C Frisvad, Line Ledsgaard

J Fungi (Basel)· July 2024

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Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper.
Christoffer V Sørensen, Julián Fernández, Anna Christina Adams, Helen H K Wildenauer, Sanne Schoffelen, Line Ledsgaard

Nat Commun· January 2024

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Phage display assisted discovery of a pH-dependent anti-α-cobratoxin antibody from a natural variable domain library.
Tulika Tulika, Rasmus W Pedersen, Charlotte Rimbault, Shirin Ahmadi, Esperanza Rivera-de-Torre, Line Ledsgaard

Protein Sci· December 2023

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An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules.
Rohit N Patel, Rachel H Clare, Line Ledsgaard, Mieke Nys, Jeroen Kool

Biochem Pharmacol· October 2023

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Cross-reactivity trends when selecting scFv antibodies against snake toxins using a phage display-based cross-panning strategy.
Christoffer V Sørensen, Line Ledsgaard, Helen H K Wildenauer, Camilla H Dahl, Tasja W Ebersole

Sci Rep· June 2023

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Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes.
Line Ledsgaard, Jack Wade, Timothy P Jenkins, Kim Boddum, Irina Oganesyan

Nat Commun· February 2023

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Advances in antibody phage display technology.
Line Ledsgaard, Anne Ljungars, Charlotte Rimbault, Christoffer V Sørensen, Tulika Tulika

Drug Discov Today· August 2022

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Generation of Multivalent Nanobody-Based Proteins with Improved Neutralization of Long α-Neurotoxins from Elapid Snakes.
Jack Wade, Charlotte Rimbault, Hanif Ali, Line Ledsgaard, Esperanza Rivera-de-Torre

Bioconjug Chem· August 2022

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discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom.
Line Ledsgaard, Andreas H Laustsen, Urska Pus, Jack Wade, Pedro Villar

MAbs· June 2022

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Synthetic antibodies block receptor binding and current-inhibiting effects of α-cobratoxin from Naja kaouthia.
Shane Miersch, Guillermo de la Rosa, Rasmus Friis, Line Ledsgaard, Kim Boddum

Protein Sci· May 2022

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Orally active bivalent VH construct prevents proliferation of F4 enterotoxigenic in weaned piglets.
Berthe Katrine Fiil, Sandra Wingaard Thrane, Michael Pichler, Tiia Kittilä, Line Ledsgaard

iScience· April 2022

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Discovery of a Recombinant Human Monoclonal Immunoglobulin G Antibody Against α-Latrotoxin From the Mediterranean Black Widow Spider ().
Sofie Føns, Line Ledsgaard, Maxim V Nikolaev, Alexander A Vassilevski, Christoffer V Sørensen

Front Immunol· July 2021

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Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses.
Georgia Bullen, Jacob D Galson, Gareth Hall, Pedro Villar, Lien Moreels, Line Ledsgaard

Front Immunol· July 2021

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An in vitro methodology for discovering broadly-neutralizing monoclonal antibodies.
Shirin Ahmadi, Manuela B Pucca, Jonas A Jürgensen, Rahel Janke, Line Ledsgaard

Sci Rep· July 2020

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History of Envenoming Therapy and Current Perspectives.
Manuela B Pucca, Felipe A Cerni, Rahel Janke, Erick Bermúdez-Méndez, Line Ledsgaard

Front Immunol· June 2020

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Unity Makes Strength: Exploring Intraspecies and Interspecies Toxin Synergism between Phospholipases A and Cytotoxins.
Manuela B Pucca, Shirin Ahmadi, Felipe A Cerni, Line Ledsgaard, Christoffer V Sørensen

Front Pharmacol· May 2020

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Engineering and design considerations for next-generation snakebite antivenoms.
Cecilie Knudsen, Line Ledsgaard, Rasmus Ibsen Dehli, Shirin Ahmadi, Christoffer Vinther Sørensen

Toxicon· September 2019

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Antibody Cross-Reactivity in Antivenom Research.
Line Ledsgaard, Timothy P Jenkins, Kristian Davidsen, Kamille Elvstrøm Krause, Andrea Martos-Esteban

Toxins (Basel)· September 2018

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Basics of Antibody Phage Display Technology.
Line Ledsgaard, Mogens Kilstrup, Aneesh Karatt-Vellatt, John McCafferty, Andreas H Laustsen

Toxins (Basel)· June 2018

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Pros and cons of different therapeutic antibody formats for recombinant antivenom development.
Andreas H Laustsen, José María Gutiérrez, Cecilie Knudsen, Kristoffer H Johansen, Erick Bermúdez-Méndez, Line Ledsgaard

Toxicon· May 2018

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