Publications by authors named "Line S Reinert"

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Role for NF-κB in herpes encephalitis pathology in mice genocopying an inborn error of IRF3-IFN immunity.
Manja Idorn, Xiangning Ding, Stefanie Fruhwürth, Søren Holste, Line S Reinert

J Exp Med· January 2026

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Lack of functional STING modulates immunity but does not protect dopaminergic neurons in the alpha-synuclein pre-formed fibrils Parkinson's disease mouse model.
Ida H Klæstrup, Line S Reinert, Sara A Ferreira, Johanne Lauritsen, Gitte U Toft

NPJ Parkinsons Dis· December 2025

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STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor.
Bao-Cun Zhang, Alice Pedersen, Line S Reinert, Ying Li, Ryo Narita

Nat Immunol· November 2025

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Sequelae of viral CNS infections including outcomes, mechanisms, and knowledge gaps.
Rachel Kelly, Line S Reinert, Søren R Paludan

Npj Viruses· November 2025

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Deleterious variants in the autophagy-related gene RB1CC1/FIP200 impair immunity to SARS-CoV-2.
Lili Hu, Renee M van der Sluis, Kennith Brian Castelino, Bao-Cun Zhang, Andreas Ronit, Line S Reinert

Nat Commun· November 2025

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STING Signaling Deficiency Exacerbates Demyelination and Immune Infiltration in Focal EAE Lesions.
Marlene T Mørch, Line S Reinert, Anouk Benmamar-Badel, Magdalena Dubik, Mark Burton

NeuroSci· October 2025

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Increased mucosal and T-cell expression of 4-1BB and PD-1 are modulated by anti-TNFα treatment in Crohn's disease.
Morten Aagaard Nielsen, Mia Bendix, Christian Lodberg Hvas, Bent Deleuran, Line S Reinert

Scand J Gastroenterol· July 2025

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Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus CNS infection.
Xiangning Ding, Xin Lai, Ida H Klaestrup, Sara R N Jensen, Morten M Nielsen, Line S Reinert

J Neuroinflammation· May 2025

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Mapping satellite glial cell heterogeneity reveals distinct spatial organization and signifies functional diversity in the dorsal root ganglion.
Ole A Ahlgreen, Mads W Hansen, Jonas Baake, Thomas E Hybel, Rachele Rossi, Line S Reinert

bioRxiv· May 2025

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Mucosal IFNλ1 mRNA-based immunomodulation effectively reduces SARS-CoV-2 induced mortality in mice.
Anna Macht, Yiqi Huang, Line S Reinert, Vincent Grass, Kristin Lohmer

EMBO Rep· September 2024

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The heat shock protein 90 inhibitor RGRN-305 attenuates SARS-CoV-2 spike protein-induced inflammation in vitro but lacks effectiveness as COVID-19 treatment in mice.
Hakim Ben Abdallah, Giorgia Marino, Manja Idorn, Line S Reinert, Anne Bregnhøj

PLoS One· September 2024

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TMEFF1 is a neuron-specific restriction factor for herpes simplex virus.
Yao Dai, Manja Idorn, Manutea C Serrero, Xiaoyong Pan, Emil A Thomsen, Line S Reinert

Nature· August 2024

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The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation.
Ensieh Farahani, Line S Reinert, Ryo Narita, Manutea C Serrero, Morten Kelder Skouboe

Cell Rep· February 2024

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ER stress induces caspase-2-tBID-GSDME-dependent cell death in neurons lytically infected with herpes simplex virus type 2.
Fanghui Ren, Ryo Narita, Ahmad S Rashidi, Stefanie Fruhwürth, Zongliang Gao, Line S Reinert

EMBO J· October 2023

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STING is redundant for host defense and pathology of COVID-19-like disease in mice.
Giorgia Marino, Baocun Zhang, Alexander Schmitz, Hanna Vf Schwensen, Line S Reinert

Life Sci Alliance· August 2023

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TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain.
Stefanie Fruhwürth, Line S Reinert, Carl Öberg, Marcelina Sakr, Marcus Henricsson

Sci Adv· August 2023

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Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen.
Zaid Taha, Rozanne Arulanandam, Glib Maznyi, Elena Godbout, Madalina E Carter-Timofte, Line S Reinert

Mol Ther· September 2022

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TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection.
Renée M van der Sluis, Lamin B Cham, Albert Gris-Oliver, Kristine R Gammelgaard, Jesper G Pedersen, Line S Reinert

EMBO J· May 2022

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Microglia Activate Early Antiviral Responses upon Herpes Simplex Virus 1 Entry into the Brain to Counteract Development of Encephalitis-Like Disease in Mice.
Georgios Katzilieris-Petras, Xin Lai, Ahmad S Rashidi, Georges M G M Verjans, Line S Reinert

J Virol· March 2022

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STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses.
Isabelle K Vila, Hanane Chamma, Alizée Steer, Mathilde Saccas, Clara Taffoni, Line S Reinert

Cell Metab· January 2022

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A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry.
Julián Valero, Laia Civit, Daniel M Dupont, Denis Selnihhin, Line S Reinert

Proc Natl Acad Sci U S A· December 2021

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The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice.
Rafael Bayarri-Olmos, Laust Bruun Johnsen, Manja Idorn, Line S Reinert, Anne Rosbjerg

Elife· November 2021

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Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility.
Jelena Tomac, Marija Mazor, Berislav Lisnić, Mijo Golemac, Daria Kveštak, Line S Reinert

Immunity· July 2021

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Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity.
Cyrielle Fougeroux, Louise Goksøyr, Manja Idorn, Vladislav Soroka, Sebenzile K Myeni, Line S Reinert

Nat Commun· January 2021

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Author Correction: SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.
David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Line S Reinert

Nat Commun· October 2020

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