Publications by authors named "Linus Tsai"

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A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types.
Jon Resch, Yuxi Li, Trevor Butler, Stefano Nardone, Christopher Jacobs, Linus T Tsai

Res Sq· October 2025

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The diabetes gene Tcf7l2 organizes gene expression in the liver and regulates amino acid metabolism.
Joanna Krawczyk, William O'Connor, Pedro Vendramini, Mareike Schell, Kiran J Biddinger, Linus T Tsai

Mol Metab· September 2025

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Regional heterogeneity of the blood-brain barrier.
Marie Blanchette, Kaja Bajc, Benjamin D Gastfriend, Caterina P Profaci, Nadine Ruderisch, Linus T Tsai

Nat Commun· August 2025

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Semaglutide and bariatric surgery induce distinct changes in the composition of mouse white adipose tissue.
Margo P Emont, Adam L Essene, Anton Gulko, Nadejda Bozadjieva-Kramer, Christopher Jacobs, Linus T Tsai

Mol Metab· May 2025

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The Diabetes Gene Organizes Gene Expression in the Liver and Regulates Amino Acid Metabolism.
Joanna Krawczyk, William O'Connor, Pedro Vendramini, Mareike Schell, Kiran J Biddinger, Linus T Tsai

bioRxiv· April 2025

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Human Bone Marrow Adipose Tissue is a Hematopoietic Niche for Leptin-Driven Monopoiesis.
Zinger Yang Loureiro, Amruta Samant, Anand Desai, Tiffany DeSouza, Haley Cirka, Linus T Tsai

bioRxiv· March 2025

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A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients.
Yered Pita-Juarez, Dimitra Karagkouni, Nikolaos Kalavros, Johannes C Melms, Sebastian Niezen, Linus T-Y Tsai

Genome Biol· March 2025

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Single-nuclear transcriptomics of lymphedema-associated adipose reveals a pro-lymphangiogenic stromal cell population.
Gregory P Westcott, Margo P Emont, Anton Gulko, Zhibo Zhou, Charissa Kim, Leo L Tsai, Linus T Tsai

bioRxiv· February 2025

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Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle.
Ariana Vargas-Castillo, Yizhi Sun, Amanda L Smythers, Louisa Grauvogel, Phillip A Dumesic, Linus T Tsai

Cell Metab· September 2024

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Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming.
Corey D Holman, Alexander P Sakers, Ryan P Calhoun, Lan Cheng, Ethan C Fein, Linus Tsai

Elife· May 2024

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AgRP neuron cis-regulatory analysis across hunger states reveals that IRF3 mediates leptin's acute effects.
Frankie D Heyward, Nan Liu, Christopher Jacobs, Natalia L S Machado, Rachael Ivison, Linus Tsai

Nat Commun· May 2024

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Protocol for flow cytometry-assisted single-nucleus RNA sequencing of human and mouse adipose tissue with sample multiplexing.
Anton Gulko, Adam Essene, Dylan Matthew Belmont-Rausch, Molly Veregge, Deepti Pant, Linus T Tsai

STAR Protoc· March 2024

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A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution.
Stefano Nardone, Roberto De Luca, Antonino Zito, Nataliya Klymko, Dimitris Nicoloutsopoulos, Linus T Tsai

Nat Commun· March 2024

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Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming.
Corey D Holman, Alexander P Sakers, Ryan P Calhoun, Lan Cheng, Ethan C Fein, Linus Tsai

bioRxiv· February 2024

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A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution.
Stefano Nardone, Roberto De Luca, Antonino Zito, Nataliya Klymko, Dimitris Nicoloutsopoulos, Linus T Tsai

bioRxiv· November 2023

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Author Correction: A single-cell atlas of human and mouse white adipose tissue.
Margo P Emont, Christopher Jacobs, Adam L Essene, Deepti Pant, Danielle Tenen, Linus T Tsai

Nature· August 2023

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Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor.
Erin J Ciampa, Padraich Flahardy, Harini Srinivasan, Christopher Jacobs, Linus Tsai

Elife· August 2023

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Genetic variants in genes involved in creatine biosynthesis in patients with severe obesity or anorexia nervosa.
Luisa S Rajcsanyi, Anne Hoffmann, Adhideb Ghosh, Birgit Matrisch-Dinkler, Yiran Zheng, Linus T Tsai

Front Genet· April 2023

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HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.
Ashot Sargsyan, Ludivine Doridot, Sarah A Hannou, Wenxin Tong, Harini Srinivasan, Linus T Tsai

JCI Insight· January 2023

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Architecture of the outbred brown fat proteome defines regulators of metabolic physiology.
Haopeng Xiao, Luiz H M Bozi, Yizhi Sun, Christopher L Riley, Vivek M Philip, Linus T Tsai

Cell· November 2022

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A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients.
Yered Pita-Juarez, Dimitra Karagkouni, Nikolaos Kalavros, Johannes C Melms, Sebastian Niezen, Linus T-Y Tsai

bioRxiv· October 2022

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A single-cell atlas of human and mouse white adipose tissue.
Margo P Emont, Christopher Jacobs, Adam L Essene, Deepti Pant, Danielle Tenen, Linus T Tsai

Nature· March 2022

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Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of .
Suraj J Patel, Nan Liu, Sam Piaker, Anton Gulko, Maynara L Andrade, Linus Tsai

Sci Transl Med· March 2022

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Genetic analysis of dietary intake identifies new loci and functional links with metabolic traits.
Jordi Merino, Hassan S Dashti, Chloé Sarnowski, Jacqueline M Lane, Petar V Todorov, Linus Tsai

Nat Hum Behav· January 2022

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Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP.
Arturo Mendoza, Catherine Tang, Jinyoung Choi, Mariana Acuña, Maya Logan, Linus Tsai

Sci Signal· November 2021

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