Publications by authors named "Lisa Saksida"

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Prefrontal parvalbumin neurons as a target for enhancing cognition in non-pathological and 22q11.2 microdeletion syndrome mice.
Tyler D Dexter, Daniel Palmer, Ashley L Schormans, Shahnaza Hamidullah, Meira M F Machado, Lisa M Saksida

Mol Psychiatry· December 2025

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Characterisation of a touchscreen-based task for assessing cognitive judgement bias in mice: a new translational tool for affective state disorder drug screening.
Laura Lopez-Cruz, Benjamin U Phillips, Lisa M Saksida, Christopher J Heath, Timothy J Bussey

Psychopharmacology (Berl)· November 2025

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Cholinergic synaptic plasticity shapes resilience and vulnerability to tau.
Kate M Onuska, Lauren A Devito, Hayley Rc Shanks, Qi Qi, Alycia M Crooks, Lisa M Saksida

bioRxiv· October 2025

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Integrating optical neuroscience tools into touchscreen operant systems.
Patrick T Piantadosi, Oren Princz-Lebel, Miguel Skirzewski, Julie R Dumont, Daniel Palmer, Lisa M Saksida

Nat Protoc· September 2025

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Characterization of a novel transgenic mouse model to investigate brain-wide activation of astrocyte Gq signaling.
Alycia M Crooks, Kate M Onuska, Geoffrey Ngo, Scheila D Schmidt, Aja E Hogan-Cann, Lisa M Saksida

Lab Anim (NY)· August 2025

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Impaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock-In Mouse Model of Amyloidopathy.
Julie R Dumont, Paul A S Sheppard, Chris Fodor, M Alexander Coto, Sabrina Yang, Lisa M Saksida

Genes Brain Behav· June 2025

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Pharmacological agents and injection stress, but not social isolation, alter cognitive judgement bias in the mouse touchscreen operant chamber.
Ashlyn Y Hersey, Paul A S Sheppard, Ryan Kim, Thu N M Pham, Laura López-Cruz, Lisa M Saksida

Sci Rep· April 2025

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Neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model of synucleinopathy prior to onset of motor symptoms.
Stephanie Tullo, Aline S Miranda, Esther Del Cid-Pellitero, Mei Peng Lim, Daniel Gallino, Lisa M Saksida

J Neurochem· August 2024

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Developmental origin of oligodendrocytes determines their function in the adult brain.
Sarah Foerster, Elisa M Floriddia, David van Bruggen, Petra Kukanja, Bastien Hervé, Lisa Saksida

Nat Neurosci· August 2024

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The Granular Retrosplenial Cortex Is Necessary in Male Rats for Object-Location Associative Learning and Memory, But Not Spatial Working Memory or Visual Discrimination and Reversal, in the Touchscreen Operant Chamber.
Paul A S Sheppard, Charlotte A Oomen, Timothy J Bussey, Lisa M Saksida

eNeuro· June 2024

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Sex-dependent cholinergic effects on amyloid pathology: A translational study.
Liliana German-Castelan, Hayley R C Shanks, Robert Gros, Takashi Saito, Takaomi C Saido, Lisa M Saksida

Alzheimers Dement· February 2024

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Refining the study of decision-making in animals: differential effects of d-amphetamine and haloperidol in a novel touchscreen-automated Rearing-Effort Discounting (RED) task and the Fixed-Ratio Effort Discounting (FRED) task.
Laura Lopez-Cruz, Benjamin U Phillips, Jonathan M Hailwood, Lisa M Saksida, Christopher J Heath

Neuropsychopharmacology· January 2024

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Reconsidering repurposing: long-term metformin treatment impairs cognition in Alzheimer's model mice.
So Yeon Cho, Eun Woo Kim, Soo Jin Park, Benjamin U Phillips, Jihyeon Jeong, Lisa M Saksida

Transl Psychiatry· January 2024

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Open science and data sharing in cognitive neuroscience with MouseBytes and MouseBytes.
Sara Memar, Eric Jiang, Vania F Prado, Lisa M Saksida, Timothy J Bussey

Sci Data· April 2023

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Continuous cholinergic-dopaminergic updating in the nucleus accumbens underlies approaches to reward-predicting cues.
Miguel Skirzewski, Oren Princz-Lebel, Liliana German-Castelan, Alycia M Crooks, Gerard Kyungwook Kim, Lisa M Saksida

Nat Commun· December 2022

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Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo.
Rachel E Lackie, Aline S de Miranda, Mei Peng Lim, Vladislav Novikov, Nimrod Madrer, Lisa M Saksida

Acta Neuropathol· November 2022

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Metabolic hormones mediate cognition.
Olivia R Ghosh-Swaby, Amy C Reichelt, Paul A S Sheppard, Jeffrey Davies, Timothy J Bussey, Lisa M Saksida

Front Neuroendocrinol· July 2022

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Decision Making in Mice During an Optimized Touchscreen Spatial Working Memory Task Sensitive to Medial Prefrontal Cortex Inactivation and NMDA Receptor Hypofunction.
Tyler D Dexter, Daniel Palmer, Ahmed M Hashad, Lisa M Saksida, Tim J Bussey

Front Neurosci· May 2022

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Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision.
Kayla M Ferko, Anna Blumenthal, Chris B Martin, Daria Proklova, Alexander N Minos, Lisa M Saksida

Elife· March 2022

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Functional dissociation of behavioral effects from acetylcholine and glutamate released from cholinergic striatal interneurons.
Ornela Kljakic, Helena Janíčková, Miguel Skirzewski, Amy Reichelt, Sara Memar, Lisa M Saksida

FASEB J· February 2022

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The spontaneous location recognition task for assessing spatial pattern separation and memory across a delay in rats and mice.
Amy C Reichelt, Cecilia P Kramar, Olivia R Ghosh-Swaby, Paul A S Sheppard, Brianne A Kent, Lisa M Saksida

Nat Protoc· December 2021

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Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing.
Sujeong Yang, Sylvain Gigout, Angelo Molinaro, Yuko Naito-Matsui, Sam Hilton, Lisa M Saksida

Mol Psychiatry· October 2021

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Evaluating Sequential Response Learning in the Rodent Operant Touchscreen System.
Helena Janickova, Ornela Kljakic, Trevor W Robbins, Lisa M Saksida, Timothy J Bussey

Curr Protoc· October 2021

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Touchscreen cognitive testing: Cross-species translation and co-clinical trials in neurodegenerative and neuropsychiatric disease.
Daniel Palmer, Julie R Dumont, Tyler D Dexter, Marco A M Prado, Elizabeth Finger, Lisa M Saksida

Neurobiol Learn Mem· July 2021

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Using touchscreen-delivered cognitive assessments to address the principles of the 3Rs in behavioral sciences.
Laura Lopez-Cruz, Timothy J Bussey, Lisa M Saksida, Christopher J Heath

Lab Anim (NY)· July 2021

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