Publications by authors named "Lloyd Ruddock"

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Expression of amyotrophic lateral sclerosis associated protein disulfide isomerase A3 D217N variant recapitulates early morphological alterations at the neuromuscular junction.
Martin Sepulveda, Francisca MartinezTraub, Patricia Ojeda, Jessica Mella, Jorge Ojeda, Lloyd Ruddock

Neurobiol Dis· October 2025

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Structural insights on perlecan and Schwartz-Jampel syndrome.
Anil A Sohail, M Kristian Koski, Lloyd W Ruddock

Matrix Biol· June 2025

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Toward Antibody Production in Genome-Minimized Strains.
Tobias Schilling, Rebekka Biedendieck, Rafael Moran-Torres, Mirva J Saaranen, Lloyd W Ruddock

ACS Synth Biol· March 2025

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Biophysical and structural studies of fibulin-2.
Anil A Sohail, M Kristian Koski, Lloyd W Ruddock

Sci Rep· July 2024

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Cytoplasmic Expression of Disulfide-Bonded Proteins: Side-by-Side Comparison between Two Competing Strategies.
Angel Castillo-Corujo, Yuko Uchida, Mirva J Saaranen, Lloyd W Ruddock

J Microbiol Biotechnol· May 2024

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Cytoplasmic production of Fabs in chemically defined media in fed-batch fermentation.
Angel Castillo-Corujo, Mirva J Saaranen, Lloyd W Ruddock

Protein Expr Purif· March 2024

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Bulky hydrophobic side chains in the β1-sandwich of microsomal triglyceride transfer protein are critical for the transfer of both triglycerides and phospholipids.
Narasimha Anaganti, Swati Valmiki, Rosario Recacha, Shahidul Islam, Steven Farber, Lloyd Ruddock

J Biol Chem· March 2024

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Komagataella phaffii Erp41 is a protein disulfide isomerase with unprecedented disulfide bond catalyzing activity when coupled to glutathione.
Arianna Palma, Lukas A Rettenbacher, Antti Moilanen, Mirva Saaranen, Brigitte Gasser, Lloyd W Ruddock

J Biol Chem· March 2024

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Design of an alternate antibody fragment format that can be produced in the cytoplasm of Escherichia coli.
Aatir A Tungekar, Lloyd W Ruddock

Sci Rep· August 2023

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Biochemical analysis of Komagataella phaffii oxidative folding proposes novel regulatory mechanisms of disulfide bond formation in yeast.
Arianna Palma, Lukas A Rettenbacher, Antti Moilanen, Mirva Saaranen, Christian Pacheco-Martinez, Lloyd Ruddock

Sci Rep· August 2023

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Mechanistic insights into the ROS-mediated inactivation of human aldehyde oxidase.
Mariam Esmaeeli, Manfred Nimtz, Lothar Jänsch, Lloyd W Ruddock, Silke Leimkühler

FEBS Lett· July 2023

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Inactivation of Human Aldehyde Oxidase by Small Sulfhydryl-Containing Reducing Agents.
Mariam Esmaeeli, Manfred Nimtz, Lothar Jänsch, Lloyd W Ruddock, Silke Leimkühler

Drug Metab Dispos· June 2023

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Highly efficient export of a disulfide-bonded protein to the periplasm and medium by the Tat pathway using CyDisCo in Escherichia coli.
Klaudia Arauzo-Aguilera, Mirva J Saaranen, Colin Robinson, Lloyd W Ruddock

Microbiologyopen· April 2023

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Production of neutralizing antibody fragment variants in the cytoplasm of E. coli for rapid screening: SARS-CoV-2 a case study.
Aatir A Tungekar, Rosario Recacha, Lloyd W Ruddock

Sci Rep· March 2023

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Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis.
Danilo Bilches Medinas, Sajid Malik, Esra Yıldız-Bölükbaşı, Janina Borgonovo, Mirva J Saaranen, Lloyd W Ruddock

EMBO J· December 2022

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Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: Toward a model of the C-P4H αβ tetramer.
Abhinandan V Murthy, Ramita Sulu, Andrey Lebedev, Antti M Salo, Kati Korhonen, Lloyd W Ruddock

J Biol Chem· December 2022

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Efficient Production of Fc Fusion Proteins in the Cytoplasm of : Dissecting and Mitigating Redox Heterogeneity.
Aatir A Tungekar, Lloyd W Ruddock

Int J Mol Sci· November 2022

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Introduction of a More Glutaredoxin-like Active Site to PDI Results in Competition between Protein Substrate and Glutathione Binding.
Mirva J Saaranen, Heli I Alanen, Kirsi E H Salo, Emmanuel Nji, Pekka Kärkkäinen, Lloyd W Ruddock

Antioxidants (Basel)· September 2022

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So you want to express your protein in Escherichia coli?
Aatir A Tungekar, Angel Castillo-Corujo, Lloyd W Ruddock

Essays Biochem· July 2021

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Efficient soluble production of folded cat allergen Fel d 1 in Escherichia coli.
Chi Zhang, Rosario Recacha, Lloyd W Ruddock, Antti Moilanen

Protein Expr Purif· April 2021

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High-resolution Crystal Structure of Human pERp1, A Saposin-like Protein Involved in IgA, IgM and Integrin Maturation in the Endoplasmic Reticulum.
Sven T Sowa, Antti Moilanen, Ekaterina Biterova, Mirva J Saaranen, Lari Lehtiö, Lloyd W Ruddock

J Mol Biol· March 2021

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The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice.
Emmi Kapiainen, Minna K Kihlström, Riikka Pietilä, Mika Kaakinen, Veli-Pekka Ronkainen, Lloyd Ruddock

Cancer Res· January 2021

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Exome Sequencing Reveals a Phenotype Modifying Variant in ZNF528 in Primary Osteoporosis With a COL1A2 Deletion.
Sini Skarp, Ji-Han Xia, Qin Zhang, Marika Löija, Alice Costantini, Lloyd W Ruddock

J Bone Miner Res· December 2020

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Cysteine 343 in the substrate binding domain is the primary S-Nitrosylated site in protein disulfide isomerase.
Jiro Ogura, Lloyd W Ruddock, Nariyasu Mano

Free Radic Biol Med· November 2020

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A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein.
Meredith H Wilson, Sujith Rajan, Aidan Danoff, Richard J White, Monica R Hensley, Lloyd Ruddock

PLoS Genet· August 2020

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