Publications by authors named "Loic Roux"

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Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity.
Ken Yamada, Samuel Hildebrand, Sarah M Davis, Rachael Miller, Faith Conroy, Loic Roux

Nucleic Acids Res· December 2021

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Gene therapy with AR isoform 2 rescues spinal and bulbar muscular atrophy phenotype by modulating AR transcriptional activity.
Wooi F Lim, Mitra Forouhan, Thomas C Roberts, Jesse Dabney, Ruth Ellerington, Loïc Roux

Sci Adv· August 2021

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A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.
Julia F Alterman, Bruno M D C Godinho, Matthew R Hassler, Chantal M Ferguson, Dimas Echeverria, Loic Roux

Nat Biotechnol· August 2019

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Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.
Maire F Osborn, Andrew H Coles, Annabelle Biscans, Reka A Haraszti, Loic Roux

Nucleic Acids Res· February 2019

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Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain.
Magali Saez-Ayala, Elsie Laban Yekwa, Clémence Mondielli, Loic Roux, Sergio Hernández

Antiviral Res· February 2019

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RNAi modulation of placental sFLT1 for the treatment of preeclampsia.
Anton A Turanov, Agnes Lo, Matthew R Hassler, Angela Makris, Ami Ashar-Patel, Loic Roux

Nat Biotechnol· November 2018

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Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles.
Reka Agnes Haraszti, Rachael Miller, Marie-Cecile Didiot, Annabelle Biscans, Julia F Alterman, Loic Roux

Mol Ther· August 2018

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Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles.
Annabelle Biscans, Reka A Haraszti, Dimas Echeverria, Rachael Miller, Marie-Cecile Didiot, Loic Roux

Mol Ther· June 2018

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Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.
Matthew R Hassler, Anton A Turanov, Julia F Alterman, Reka A Haraszti, Andrew H Coles, Loïc Roux

Nucleic Acids Res· March 2018

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How to Control HTLV-1-Associated Diseases: Preventing Cellular Infection Using Antiviral Therapy.
Amandine Pasquier, Sandrine Alais, Loic Roux, Maria-Isabel Thoulouze, Karine Alvarez

Front Microbiol· March 2018

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Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay.
Bruno M D C Godinho, James W Gilbert, Reka A Haraszti, Andrew H Coles, Annabelle Biscans, Loic Roux

Nucleic Acid Ther· December 2017

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5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.
Reka A Haraszti, Loic Roux, Andrew H Coles, Anton A Turanov, Julia F Alterman

Nucleic Acids Res· July 2017

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Enzymatic synthesis of acyclic nucleoside thiophosphonate diphosphates: effect of the α-phosphorus configuration on HIV-1 RT activity.
Stéphane Priet, Loic Roux, Magali Saez-Ayala, François Ferron, Bruno Canard

Antiviral Res· May 2015

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Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: synthesis, antiviral activity and decomposition study.
Loïc Roux, Stéphane Priet, Nadine Payrot, Clément Weck, Maëlenn Fournier

Eur J Med Chem· May 2013

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Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication.
Karine Barral, Clément Weck, Nadine Payrot, Loic Roux, Céline Durafour

Eur J Med Chem· September 2011

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