Publications by authors named "Longjia Yan"

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Discovery of a macrocyclic FAK inhibitor GZD-257 for treatment of glioblastoma.
Ting Wu, Yaqing Zuo, Kehui Chen, Ying Xu, Daili Wu, Longjia Yan

Bioorg Med Chem Lett· October 2025

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Development of a novel fluorescent probe for the Selective and sequential imaging of fluoride and hypochlorite.
Tingting Feng, Dan Li, Jiaxue Yang, Ting Yang, Ting Wu, Longjia Yan

Spectrochim Acta A Mol Biomol Spectrosc· March 2025

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Discovery of noncovalent diaminopyrimidine-based Inhibitors for glioblastoma via a dual FAK/DNA targeting strategy.
Yi Wei, Xiaoling He, Zhiwu Long, Yi Le, Li Liu, Longjia Yan

Eur J Med Chem· March 2025

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A novel fluorescent probe for rapid and selective detection of fluoride ions in living cells.
Tingting Feng, Jiaxue Yang, Yi Wang, Taozhu Hu, Longjia Yan

Anal Methods· January 2025

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Synthesis of Quinolinoneylnitrones and Coumarinylnitrones via a Cascade Hydroamination and Aza-MBH-Type Reaction.
Yan Zhang, Qingtao Wang, Zhiwu Long, Yaqing Zuo, Li Liu, Longjia Yan

J Org Chem· July 2024

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Design, Synthesis, and Anti-Leukemic Evaluation of a Series of Dianilinopyrimidines by Regulating the Ras/Raf/MEK/ERK and STAT3/c-Myc Pathways.
Chaoyan Wang, Bo Wang, Yu Mou, Xiang Liu, Qiqing Chen, Longjia Yan, Yanmei Li

Molecules· April 2024

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Design, synthesis and antitumor activity of 4-arylamine substituted pyrimidine derivatives as noncovalent EGFR inhibitors overcoming C797S mutation.
Yaqing Zuo, Zhiwu Long, Rongrong Li, Yi Le, Silong Zhang, Longjia Yan

Eur J Med Chem· February 2024

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Design, synthesis and biological evaluation of 4-arylamino-pyrimidine derivatives as focal adhesion kinase inhibitors.
Zhiwu Long, Yaqing Zuo, Rongrong Li, Yi Le, Yawen Dong, Longjia Yan

Bioorg Chem· November 2023

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Design, synthesis and evaluation of novel pyrimidinylaminothiophene derivatives as FGFR1 inhibitors against human glioblastoma multiforme.
Yong-Liang Li, Long-Jia Yan, Hui-Xiong Chen, Ban-Kang Ruan, Pascal Dao

Eur J Med Chem· November 2023

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Design, synthesis and biological evaluation of a series of dianilinopyrimidines as EGFR inhibitors.
Longjia Yan, Qin Wang, Li Liu, Yi Le

J Enzyme Inhib Med Chem· December 2022

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Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors.
Yaqing Zuo, Rongrong Li, Yan Zhang, Guochen Bao, Yi Le, Longjia Yan

J Enzyme Inhib Med Chem· December 2022

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Discovery of 4-nitro-3-phenylisoxazole derivatives as potent antibacterial agents derived from the studies of [3 + 2] cycloaddition.
Yan Zhang, Zhiwu Long, Longjia Yan, Li Liu, Lan Yang

RSC Adv· September 2022

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Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities against tumour cells.
Yan Zhang, Qin Wang, Luolan Li, Yi Le, Li Liu, Jing Yang, Longjia Yan

J Enzyme Inhib Med Chem· December 2021

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Design, synthesis and biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment.
Yi Le, Yiyuan Gan, Yihong Fu, Jiamin Liu, Wen Li, Guiping Ouyang, Longjia Yan

J Enzyme Inhib Med Chem· December 2020

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Microwave-assisted synthesis of 7-azaindoles iron-catalyzed cyclization of an -haloaromatic amine with terminal alkynes.
Yi Le, Zhisong Yang, Yumei Chen, Dongmei Chen, Longjia Yan, Guiping Ouyang

RSC Adv· December 2019

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Development of novel theranostic agents for in vivo amyloid imaging and protective effects on human neuroblastoma cells.
Yongliang Li, Longjia Yan, Jing Cai, Wanzheng Zhang, Li Li

Eur J Med Chem· November 2019

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Aromatic-turmerone ameliorates imiquimod-induced psoriasis-like inflammation of BALB/c mice.
Yong-Liang Li, Zhi-Yun Du, Peng-Hui Li, Longjia Yan, Wei Zhou, Yan-Xiong Fang

Int Immunopharmacol· November 2018

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Synthesis and structure-activity relationship study of diaryl[d,f][1,3]diazepines as potential anti-cancer agents.
Longjia Yan, Hui Wang, Yunpeng Chen, Zhiwei Li, Yazhong Pei

Mol Divers· May 2018

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Syntheses of novel diaryl[d,f ][1,3]diazepines via one-pot Suzuki coupling followed by direct ring closure with carboxylic acids.
Longjia Yan, Xin Che, Xu Bai, Yazhong Pei

Mol Divers· August 2012

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