Publications by authors named "Lorah Perlee"

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Safety, Efficacy, and Patient-Reported Outcomes From a Phase 2 Randomized Trial of Pozelimab and Cemdisiran Combination in Patients With Paroxysmal Nocturnal Hemoglobinuria.
Jun-Ho Jang, Raymond Siu Ming Wong, Christopher Hartford, Rodrigo Pavani, Lisa Aurand, Lorah Perlee

EJHaem· August 2025

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A TMPRSS6-inhibiting mAb improves disease in a β-thalassemia mouse model and reduces iron in healthy humans.
Heinrich E Lob, Nikhil Singh, Kusha Mohammadi, Larisa Ivanova, Beth Crowell, Lorah Perlee

JCI Insight· June 2025

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The patient experience of CHAPLE disease: results from interviews conducted as part of a clinical trial for an ultra-rare condition.
Leighann Litcher-Kelly, Ahmet Ozen, Sarah Ollis, Hagit Baris Feldman, Andrew Yaworsky, Lorah Perlee

Orphanet J Rare Dis· February 2025

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Pozelimab for CHAPLE disease: results from in-trial interviews and clinical outcome assessments.
Leighann Litcher-Kelly, Ahmet Ozen, Sarah Ollis, Hagit Baris Feldman, Andrew Yaworsky, Lorah Perlee

Orphanet J Rare Dis· August 2024

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Evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy disease: an open-label phase 2 and 3 study.
Ahmet Ozen, Voranush Chongsrisawat, Asena Pinar Sefer, Burcu Kolukisa, Jessica J Jalbert, Lorah Perlee

Lancet· February 2024

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Blocking common γ chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models.
Audrey Le Floc'h, Kirsten Nagashima, Dylan Birchard, George Scott, Li-Hong Ben, Lorah Perlee

Sci Transl Med· January 2023

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REGN1908/1909 prevented cat allergen-induced early asthmatic responses in an environmental exposure unit.
Frederic J de Blay, Alina Gherasim, Nathalie Domis, Pretty Meier, Furat Shawki, Lorah Perlee

J Allergy Clin Immunol· December 2022

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Intravitreal Nesvacumab (Anti-Angiopoietin-2) Plus Aflibercept in Neovascular AMD: Phase 2 ONYX Randomized Trial.
Jeffrey S Heier, Allen C Ho, David S Boyer, Karl Csaky, Robert Vitti, Lorah Perlee

J Vitreoretin Dis· December 2022

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INTRAVITREAL NESVACUMAB (ANTIANGIOPOIETIN 2) PLUS AFLIBERCEPT IN DIABETIC MACULAR EDEMA: Phase 2 RUBY Randomized Trial.
David M Brown, David S Boyer, Karl Csaky, Robert Vitti, Lorah Perlee

Retina· June 2022

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Cat allergen exposure in a naturalistic exposure chamber: A prospective observational study in cat-allergic subjects.
William H Yang, Suzanne Kelly, Laura Haya, Rym Mehri, Divya Ramesh, Lorah Perlee

Clin Exp Allergy· February 2022

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Novel antibody cocktail targeting Bet v 1 rapidly and sustainably treats birch allergy symptoms in a phase 1 study.
Philippe Gevaert, Jarno De Craemer, Natalie De Ruyck, Sylvie Rottey, Jan de Hoon, Lorah Perlee

J Allergy Clin Immunol· January 2022

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Environmental exposure unit simulates natural seasonal birch pollen exposures while maximizing change in allergic symptoms.
Anne K Ellis, Michelle DeVeaux, Lisa Steacy, Divya Ramesh, Maria Suprun, Lorah T Perlee

Ann Allergy Asthma Immunol· October 2021

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Intravitreal Combined Aflibercept + Anti-Platelet-Derived Growth Factor Receptor β for Neovascular Age-Related Macular Degeneration: Results of the Phase 2 CAPELLA Trial.
Jeffrey S Heier, Charles C Wykoff, Nadia K Waheed, John W Kitchens, Sunil S Patel, Lorah Perlee

Ophthalmology· February 2020

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Risk Alleles Associated with Neovascularization in a Pachychoroid Phenotype.
Kunal K Dansingani, Lorah T Perlee, Sara Hamon, May Lee, Vinnie P Shah

Ophthalmology· December 2016

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Inclusion of genotype with fundus phenotype improves accuracy of predicting choroidal neovascularization and geographic atrophy.
Lorah T Perlee, Aruna T Bansal, Karen Gehrs, Jeffrey S Heier, Karl Csaky

Ophthalmology· September 2013

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Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration.
Gregory S Hageman, Karen Gehrs, Serguei Lejnine, Aruna T Bansal, Margaret M Deangelis, Lorah T Perlee

Hum Genomics· July 2011

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Identification of diagnostic biomarkers for infection in premature neonates.
Stephen F Kingsmore, Neil Kennedy, Henry L Halliday, Jennifer C Van Velkinburgh, Shengiang Zhong, Lorah Perlee

Mol Cell Proteomics· October 2008

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Cellular and tissue localization of globotriaosylceramide in Fabry disease.
Hasan Askari, Christine R Kaneski, Cristina Semino-Mora, Priya Desai, Agnes Ang, Lorah T Perlee

Virchows Arch· October 2007

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Immunoassay and antibody microarray analysis of the HUPO Plasma Proteome Project reference specimens: systematic variation between sample types and calibration of mass spectrometry data.
Brian B Haab, Bernhard H Geierstanger, George Michailidis, Frank Vitzthum, Sara Forrester, Lorah Perlee

Proteomics· August 2005

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Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: a conference report.
Jean W Lee, Russ S Weiner, Jeff M Sailstad, Ronald R Bowsher, Dean W Knuth, Lorah Perlee

Pharm Res· April 2005

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Relative HLA-DRB1*04 allele frequencies in five United States populations found in a hematopoietic stem cell volunteer donor registry and seven new DRB1*04 alleles.
Deborah S Chen, Ting F Tang, Helena Pulyaeva, Rebecca Slack, Bin Tu, Lorah Perlee

Hum Immunol· August 2002

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