Publications by authors named "Lourdes Isaac"

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Complement C3 deficiency enhances renal leptospiral load and inflammation while impairing T cell differentiation during chronic infection.
Leonardo Moura Midon, Amaro Nunes Duarte Neto, Ana Maria Gonçalves da Silva, Marcos Bryan Heinemann, Suman Kundu, Lourdes Isaac

Infect Immun· December 2025

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Culture-attenuated pathogenic Leptospira lose the ability to survive complement lytic activity due to decreased C4BP uptake.
A Carolina Sierra Vargas, Nery López González, Alejandro de la Peña Moctezuma, Angela Silva Barbosa, Lourdes Isaac

Microbes Infect· December 2025

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Proteolytic activity of secreted proteases from pathogenic leptospires and effects on phagocytosis by murine macrophages.
Thais A Amamura, Daniella Dos S Courrol, Angela S Barbosa, Ildefonso A Silva-Junior, Tiago F da Silva, Lourdes Isaac

Microbes Infect· April 2025

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Complement C3 Deficiency Enhances Renal Leptospiral Load and Inflammation While Impairing T Cell Differentiation During Chronic Infection.
Leonardo Moura Midon, Amaro Nunes Duarte Neto, Ana Maria Gonçalves da Silva, Marcos Bryan Heinemann, Suman Kundu, Lourdes Isaac

bioRxiv· April 2025

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Murine C3 of the complement system affects infection by Leptospira interrogans.
Julia Avian Vassalakis, Denise Harumi Silva Yamashita, Leonardo Moura Midon, Bruno Cogliati, Marcos Bryan Heinemann, Lourdes Isaac

Microbes Infect· February 2025

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The Leptospira interrogans proteome's response to zinc highlights the potential involvement of this metal in translational-machinery and virulence.
Amanda Silva Hecktheuer, Cassia Moreira Santos, Fabienne Antunes Ferreira, Angela Silva Barbosa, Lourdes Isaac

Biometals· December 2024

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Complement system component 3 deficiency modulates the phenotypic profile of murine macrophages.
Tiago Francisco da Silva, Thaís Akemi Amamura, Iuri Cordeiro Valadão, Milena Carvalho Carneiro, Vanessa Morais Freitas, Lourdes Isaac

Cell Immunol· November 2024

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Analysis of Complement Factor H gene polymorphisms and their association with clinical manifestations ofleptospirosis.
Lazara Elena Santiesteban-Lores, Leonardo Moura Midon, ThirsaAlvares Franco, Luciano Marcondes de Oliveira, Sumire Hibi, Lourdes Isaac

Immunogenetics· November 2024

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Human leptospirosis: In search for a better vaccine.
Isabela Resende Azevedo, Thais Akemi Amamura, Lourdes Isaac

Scand J Immunol· November 2023

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Editorial: Leptospirosis: pathogenesis, clinical and epidemiological aspects.
Angela S Barbosa, Kanitha Patarakul, Lourdes Isaac

Front Cell Infect Microbiol· May 2023

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Sph2 and Sph2: Identification of B-Cell Linear Epitopes in Sphingomyelinase 2 (Sph2), Naturally Recognized by Patients Infected by Pathogenic Leptospires.
Laura Sant'Anna Ataides, Fernanda de Moraes Maia, Fernando Paiva Conte, Lourdes Isaac, Angela Silva Barbosa

Vaccines (Basel)· February 2023

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A rare association between factor H deficiency and lupus: Case report and experimental treatment with curcumin.
Ana Catarina Lunz Macedo, Lazara Elena Santisteban Lores, José Antonio Tavares Albuquerque, Nilo José Coelho Duarte, Paschoalina Romano, Lourdes Isaac

Front Pediatr· November 2022

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Leptolysin, a secreted metalloprotease of the pappalysin family with broad-spectrum activity.
Daniella Dos Santos Courrol, Cristiane Castilho Fernandes da Silva, Luan Gavião Prado, Rosa Maria Chura-Chambi, Ligia Morganti, Lourdes Isaac

Front Cell Infect Microbiol· September 2022

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Complement System in Alcohol-Associated Liver Disease.
Lazara Elena Santiesteban-Lores, Milena Carvalho Carneiro, Lourdes Isaac, Lorena Bavia

Immunol Lett· August 2021

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Contribution of Complement System pathways to the killing of Leptospira spp.
Priscilla Yuri Okochi Alves da Silva, Leonardo Moura Midon, Marcos Bryan Heinemann, Dewton de Moraes Vasconcelos, Angela Silva Barbosa, Lourdes Isaac

Microbes Infect· July 2021

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The Role of Properdin in Killing of Non-Pathogenic .
Adriana Patricia Granados Martinez, Patrícia Antonia Estima Abreu, Silvio de Arruda Vasconcellos, Paulo Lee Ho, Viviana P Ferreira, Lourdes Isaac

Front Immunol· June 2021

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A double edged-sword - The Complement System during SARS-CoV-2 infection.
Lazara Elena Santiesteban-Lores, Thais Akemi Amamura, Tiago Francisco da Silva, Leonardo Moura Midon, Milena Carvalho Carneiro, Lourdes Isaac

Life Sci· May 2021

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Complement Resistance Assays.
Lourdes Isaac, Angela Silva Barbosa

Methods Mol Biol· March 2021

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Strategies used by Leptospira spirochetes to evade the host complement system.
Angela Silva Barbosa, Lourdes Isaac

FEBS Lett· August 2020

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Cytokine Profile in Early Infection by in A/J Mice.
Lorena Bavia, Íris A de Castro, Mariane Tami Amano, Ana Maria Gonçalves da Silva, Silvio Arruda Vasconcellos, Lourdes Isaac

J Immunol Res· April 2020

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Culture-attenuated pathogenic Leptospira lose the ability to survive to complement-mediated-killing due to lower expression of factor H binding proteins.
Azaf Moreno-Torres, Irving R Malvido-Jiménez, Alejandro de la Peña-Moctezuma, Luz O Castillo Sánchez, Tatiana R Fraga, Lourdes Isaac

Microbes Infect· February 2020

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Secreted Proteases Degrade Extracellular Matrix and Plasma Proteins From the Host.
Ludmila B da Silva, Milene C Menezes, Eduardo S Kitano, Ana K Oliveira, Afonso G Abreu, Lourdes Isaac

Front Cell Infect Microbiol· April 2019

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Role of Murine Complement Component C5 in Acute Infection by Pathogenic .
Íris A de Castro, Lorena Bavia, Tatiana R Fraga, Mariane T Amano, Leandro C D Breda, Lourdes Isaac

Front Cell Infect Microbiol· March 2019

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thermolysin refolded at high pressure and alkaline pH displays proteolytic activity against complement C3.
Rosa Maria Chura-Chambi, Tatiana Rodrigues Fraga, Ludmila Bezerra da Silva, Bruno Bernardi Yamamoto, Lourdes Isaac

Biotechnol Rep (Amst)· September 2018

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Binding of human complement C1 sterase inhibitor to Leptospira spp.
Leandro Carvalho Dantas Breda, Silvio Arruda Vasconcellos, Dewton de Moraes Vasconcelos, Lourdes Isaac

Immunobiology· February 2018

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