Publications by authors named "Lubing Gu"

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An MDM2 degrader shows potent cytotoxicity to MDM2-overexpressing acute lymphoblastic leukemia cells with minimal toxicity to normal cells/tissues.
Tao Liu, Lubing Gu, Anna Mui, Zhongzhi Wu, Najah Albadari

Cancer Lett· August 2024

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Synthesis and biological evaluation of dual MDM2/XIAP inhibitors based on the tetrahydroquinoline scaffold.
Najah Albadari, Yang Xie, Tao Liu, Rui Wang, Lubing Gu

Eur J Med Chem· July 2023

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MYCN mRNA degradation and cancer suppression by a selective small-molecule inhibitor in MYCN-amplified neuroblastoma.
Tao Liu, Lubing Gu, Zhongzhi Wu, Najah Albadari, Wei Li

Front Oncol· November 2022

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Discovery of -(3,4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-]quinoline-8-sulfonamide as a Potent Dual MDM2/XIAP Inhibitor.
Zhongzhi Wu, Lubing Gu, Sicheng Zhang, Tao Liu, Pradeep B Lukka

J Med Chem· February 2021

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Upregulation of p53 through induction of MDM2 degradation: Anthraquinone analogs.
Alexander B Draganov, Xiaoxiao Yang, Abiodun Anifowose, Ladie Kimberly C De La Cruz, Chaofeng Dai, Lubing Gu

Bioorg Med Chem· September 2019

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Mutual regulation of MDM4 and TOP2A in cancer cell proliferation.
Tao Liu, Hailong Zhang, Sha Yi, Lubing Gu, Muxiang Zhou

Mol Oncol· May 2019

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Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice.
Lubing Gu, Hailong Zhang, Tao Liu, Alexander Draganov, Sha Yi

Mol Cancer Ther· February 2018

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Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment.
Lubing Gu, Hailong Zhang, Tao Liu, Sheng Zhou, Yuhong Du

Cancer Cell· October 2016

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Inhibition of MDM2 by nilotinib contributes to cytotoxicity in both Philadelphia-positive and negative acute lymphoblastic leukemia.
Hailong Zhang, Lubing Gu, Tao Liu, Kuang-Yueh Chiang, Muxiang Zhou

PLoS One· October 2015

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Targeting MYCN IRES in MYCN-amplified neuroblastoma with miR-375 inhibits tumor growth and sensitizes tumor cells to radiation.
Hailong Zhang, Tao Liu, Sha Yi, Lubing Gu, Muxiang Zhou

Mol Oncol· August 2015

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Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival.
Tao Liu, Hailong Zhang, Jing Xiong, Sha Yi, Lubing Gu

Mol Cancer· March 2015

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Berberine represses DAXX gene transcription and induces cancer cell apoptosis.
Jiansha Li, Lubing Gu, Hailong Zhang, Tao Liu, Dan Tian

Lab Invest· March 2013

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Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway.
Mei Huang, Hailong Zhang, Tao Liu, Dan Tian, Lubing Gu

Mol Cancer Ther· February 2013

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Methylation of RASSF1A gene promoter is regulated by p53 and DAXX.
Hailong Zhang, Jing He, Jiansha Li, Dan Tian, Lubing Gu

FASEB J· January 2013

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MDM2 regulates vascular endothelial growth factor mRNA stabilization in hypoxia.
Sheng Zhou, Lubing Gu, Jing He, Hailong Zhang, Muxiang Zhou

Mol Cell Biol· December 2011

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Crosstalk between MYCN and MDM2-p53 signal pathways regulates tumor cell growth and apoptosis in neuroblastoma.
Jing He, Lubing Gu, Hailong Zhang, Muxiang Zhou

Cell Cycle· September 2011

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Degradation of MDM2 by the interaction between berberine and DAXX leads to potent apoptosis in MDM2-overexpressing cancer cells.
Xiaoling Zhang, Lubing Gu, Jiansha Li, Noopur Shah, Jing He

Cancer Res· December 2010

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Translation of TRAF1 is regulated by IRES-dependent mechanism and stimulated by vincristine.
Lin Yang, Lubing Gu, Zhuoya Li, Muxiang Zhou

Nucleic Acids Res· July 2010

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Regulation of XIAP translation and induction by MDM2 following irradiation.
Lubing Gu, Ningxi Zhu, Hongying Zhang, Donald L Durden, Yue Feng

Cancer Cell· May 2009

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Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells.
Ningxi Zhu, Lubing Gu, Fengzhi Li, Muxiang Zhou

Mol Cancer Ther· May 2008

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Tissue factor/FVIIa activates Bcl-2 and prevents doxorubicin-induced apoptosis in neuroblastoma cells.
Jun Fang, Lubing Gu, Ningxi Zhu, Hao Tang, Carlos S Alvarado

BMC Cancer· March 2008

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Contribution of STAT3 to the activation of survivin by GM-CSF in CD34+ cell lines.
Lubing Gu, Kuang-Yueh Chiang, Ningxi Zhu, Harry W Findley, Muxiang Zhou

Exp Hematol· June 2007

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KLF5 Interacts with p53 in regulating survivin expression in acute lymphoblastic leukemia.
Ningxi Zhu, Lubing Gu, Harry W Findley, Ceshi Chen, Jin-Tang Dong

J Biol Chem· May 2006

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Expression of inhibitor-of-apoptosis protein (IAP) livin by neuroblastoma cells: correlation with prognostic factors and outcome.
Dae-Kwang Kim, Carlos S Alvarado, Carlos R Abramowsky, Lubing Gu, Muxiang Zhou

Pediatr Dev Pathol· January 2006

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Transcriptional repression of the eukaryotic initiation factor 4E gene by wild type p53.
Ningxi Zhu, Lubing Gu, Harry W Findley, Muxiang Zhou

Biochem Biophys Res Commun· October 2005

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