Publications by authors named "Luc Pilotte"

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Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes.
Marie Solvay, Pauline Holfelder, Simon Klaessens, Luc Pilotte, Vincent Stroobant

J Immunother Cancer· June 2023

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Investigation of chalcogen bioisosteric replacement in a series of heterocyclic inhibitors of tryptophan 2,3-dioxygenase.
Arina Kozlova, Léopold Thabault, Nicolas Dauguet, Marine Deskeuvre, Vincent Stroobant, Luc Pilotte

Eur J Med Chem· January 2022

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Correction to "Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase".
Arina Kozlova, Léopold Thabault, Maxime Liberelle, Simon Klaessens, Julien R C Prévost, Luc Pilotte

J Med Chem· September 2021

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Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase.
Arina Kozlova, Léopold Thabault, Maxime Liberelle, Simon Klaessens, Julien R C Prévost, Luc Pilotte

J Med Chem· August 2021

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Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase.
Simon Klaessens, Vincent Stroobant, Delia Hoffmann, Mads Gyrd-Hansen, Luc Pilotte

Proc Natl Acad Sci U S A· June 2021

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IDO1 and TDO inhibitory evaluation of analogues of the marine pyrroloiminoquinone alkaloids: Wakayin and Tsitsikammamines.
Thomas Levy, Laura Marchand, Vincent Stroobant, Luc Pilotte, Benoît Van den Eynde

Bioorg Med Chem Lett· May 2021

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TGFβ1 neutralization displays therapeutic efficacy through both an immunomodulatory and a non-immune tumor-intrinsic mechanism.
Stefania Canè, Jacques Van Snick, Catherine Uyttenhove, Luc Pilotte, Benoit J Van den Eynde

J Immunother Cancer· February 2021

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Inhibition of Tryptophan-Dioxygenase Activity Increases the Antitumor Efficacy of Immune Checkpoint Inhibitors.
Florence Schramme, Stefano Crosignani, Kim Frederix, Delia Hoffmann, Luc Pilotte

Cancer Immunol Res· January 2020

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Induction of tryptophan 2,3-dioxygenase expression in human monocytic leukemia/lymphoma cell lines THP-1 and U937.
Delia Hoffmann, Luc Pilotte, Vincent Stroobant, Benoit J Van den Eynde

Int J Tryptophan Res· December 2019

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Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes.
Ciriana Orabona, Giada Mondanelli, Maria T Pallotta, Agostinho Carvalho, Elisa Albini, Luc Pilotte

JCI Insight· March 2018

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Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance.
Marc Hennequart, Luc Pilotte, Stefania Cane, Delia Hoffmann, Vincent Stroobant

Cancer Immunol Res· August 2017

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Apolipoproteins L control cell death triggered by TLR3/TRIF signaling in dendritic cells.
Sophie Uzureau, Caroline Coquerelle, Corentin Vermeiren, Pierrick Uzureau, Annette Van Acker, Luc Pilotte

Eur J Immunol· August 2016

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Extensive profiling of the expression of the indoleamine 2,3-dioxygenase 1 protein in normal and tumoral human tissues.
Ivan Théate, Nicolas van Baren, Luc Pilotte, Pierre Moulin, Pierre Larrieu

Cancer Immunol Res· February 2015

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Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.
Ute F Röhrig, Somi Reddy Majjigapu, Marc Chambon, Sylvian Bron, Luc Pilotte

Eur J Med Chem· September 2014

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Indoleamine 2,3-dioxygenase inhibitory activity of derivatives of marine alkaloid tsitsikammamine A.
Eduard Dolušić, Pierre Larrieu, Céline Meinguet, Delphine Colette, Arnaud Rives, Luc Pilotte

Bioorg Med Chem Lett· January 2013

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Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition.
Ute F Röhrig, Somi Reddy Majjigapu, Aurélien Grosdidier, Sylvian Bron, Vincent Stroobant, Luc Pilotte

J Med Chem· June 2012

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Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase.
Luc Pilotte, Pierre Larrieu, Vincent Stroobant, Didier Colau, Eduard Dolusic

Proc Natl Acad Sci U S A· February 2012

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Minimal tolerance to a tumor antigen encoded by a cancer-germline gene.
Ivo J Huijbers, Saïdi M Soudja, Catherine Uyttenhove, Michel Buferne, Else-Marit Inderberg-Suso, Luc Pilotte

J Immunol· January 2012

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Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.
Eduard Dolusić, Pierre Larrieu, Laurence Moineaux, Vincent Stroobant, Luc Pilotte

J Med Chem· August 2011

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Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors.
Eduard Dolušić, Pierre Larrieu, Sébastien Blanc, Frédéric Sapunaric, Jenny Pouyez, Luc Pilotte

Eur J Med Chem· July 2011

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Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors.
Eduard Dolušić, Pierre Larrieu, Sébastien Blanc, Frédéric Sapunaric, Bernadette Norberg, Luc Pilotte

Bioorg Med Chem· February 2011

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Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase.
Catherine Uyttenhove, Luc Pilotte, Ivan Théate, Vincent Stroobant, Didier Colau

Nat Med· October 2003

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