Publications by authors named "Luca Gerosa"

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RIT1M90I Is a Driver of Lung Adenocarcinoma Tumorigenesis and Resistance to Targeted Therapy.
Ashley V DiMarco, Mirunalini Ravichandran, Jeff Lau, Anthony Lima, Jennifer Lacap, Luca Gerosa

Cancer Res· September 2025

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Cooperation between the Hippo and MAPK pathway activation drives acquired resistance to TEAD inhibition.
Sayantanee Paul, Thijs J Hagenbeek, Julien Tremblay, Vasumathi Kameswaran, Christy Ong, Luca Gerosa

Nat Commun· February 2025

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CDK2 activity crosstalk on the ERK kinase translocation reporter can be resolved computationally.
Timothy E Hoffman, Chengzhe Tian, Varuna Nangia, Chen Yang, Sergi Regot, Luca Gerosa

Cell Syst· January 2025

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The impact of bicuspid valve morphology on the selection of transcatheter aortic valve implantation devices: an study.
Benedetta Grossi, Giulia Luraghi, Sara Barati, Chiara Forte, Luca Gerosa

Eur Heart J Imaging Methods Pract· January 2025

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Computational modeling of drug response identifies mutant-specific constraints for dosing panRAF and MEK inhibitors in melanoma.
Andrew Goetz, Frances Shanahan, Logan Brooks, Eva Lin, Rana Mroue, Luca Gerosa

bioRxiv· August 2024

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Computational Modeling of Drug Response Identifies Mutant-Specific Constraints for Dosing panRAF and MEK Inhibitors in Melanoma.
Andrew Goetz, Frances Shanahan, Logan Brooks, Eva Lin, Rana Mroue, Luca Gerosa

Cancers (Basel)· August 2024

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Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction.
Jia-Yun Chen, Clemens Hug, José Reyes, Chengzhe Tian, Luca Gerosa

Cell Rep· March 2023

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Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance.
Fabian Fröhlich, Luca Gerosa, Jeremy Muhlich, Peter K Sorger

Mol Syst Biol· February 2023

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Multiplexed and reproducible high content screening of live and fixed cells using Dye Drop.
Caitlin E Mills, Kartik Subramanian, Marc Hafner, Mario Niepel, Luca Gerosa

Nat Commun· November 2022

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Structural basis for SHOC2 modulation of RAS signalling.
Nicholas P D Liau, Matthew C Johnson, Saeed Izadi, Luca Gerosa, Michal Hammel

Nature· September 2022

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Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy.
Thomas S C Ng, Huiyu Hu, Stefan Kronister, Chanseo Lee, Ran Li, Luca Gerosa

Sci Adv· April 2022

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Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells.
Luca Gerosa, Christopher Chidley, Fabian Fröhlich, Gabriela Sanchez, Sang Kyun Lim

Cell Syst· November 2020

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Reserve Flux Capacity in the Pentose Phosphate Pathway Enables Escherichia coli's Rapid Response to Oxidative Stress.
Dimitris Christodoulou, Hannes Link, Tobias Fuhrer, Karl Kochanowski, Luca Gerosa

Cell Syst· May 2018

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Few regulatory metabolites coordinate expression of central metabolic genes in Escherichia coli.
Karl Kochanowski, Luca Gerosa, Simon F Brunner, Dimitris Christodoulou, Yaroslav V Nikolaev

Mol Syst Biol· January 2017

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Elucidation of Genetic Interactions in the Yeast GATA-Factor Network Using Bayesian Model Selection.
Andreas Milias-Argeitis, Ana Paula Oliveira, Luca Gerosa, Laura Falter, Uwe Sauer

PLoS Comput Biol· March 2016

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Real-time metabolome profiling of the metabolic switch between starvation and growth.
Hannes Link, Tobias Fuhrer, Luca Gerosa, Nicola Zamboni, Uwe Sauer

Nat Methods· November 2015

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Pseudo-transition Analysis Identifies the Key Regulators of Dynamic Metabolic Adaptations from Steady-State Data.
Luca Gerosa, Bart R B Haverkorn van Rijsewijk, Dimitris Christodoulou, Karl Kochanowski, Thomas S B Schmidt

Cell Syst· October 2015

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Coordination of microbial metabolism.
Victor Chubukov, Luca Gerosa, Karl Kochanowski, Uwe Sauer

Nat Rev Microbiol· May 2014

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Dissecting specific and global transcriptional regulation of bacterial gene expression.
Luca Gerosa, Karl Kochanowski, Matthias Heinemann, Uwe Sauer

Mol Syst Biol· April 2013

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Functioning of a metabolic flux sensor in Escherichia coli.
Karl Kochanowski, Benjamin Volkmer, Luca Gerosa, Bart R Haverkorn van Rijsewijk, Alexander Schmidt

Proc Natl Acad Sci U S A· January 2013

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Regulation and control of metabolic fluxes in microbes.
Luca Gerosa, Uwe Sauer

Curr Opin Biotechnol· August 2011

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