Publications by authors named "Luca Simula"

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Citrate oscillations during cell cycle are a targetable vulnerability in cancer cells.
Philippe Icard, Marco Alifano, Luca Simula

Biochim Biophys Acta Rev Cancer· July 2025

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Degrading cancer cell mitochondria to improve T cell-mediated killing.
Luca Simula, Emmanuel Donnadieu

Nat Nanotechnol· July 2025

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Inhibition of Atg7 in intestinal epithelial cells drives resistance against Citrobacter rodentium.
David Cune, Caterina Luana Pitasi, Alessia Rubiola, Trinath Jamma, Luca Simula

Cell Death Dis· February 2025

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Why and how citrate may sensitize malignant tumors to immunotherapy.
Philippe Icard, Mathilde Prieto, Antoine Coquerel, Ludovic Fournel, Joseph Gligorov, Luca Simula

Drug Resist Updat· January 2025

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Hyaluronan-based hydrogel delivering glucose to mesenchymal stem cells intended to treat osteoarthritis.
Paula Gonzalez-Fernandez, Luca Simula, Sébastien Jenni, Olivier Jordan, Eric Allémann

Int J Pharm· May 2024

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Mitochondrial metabolism sustains CD8 T cell migration for an efficient infiltration into solid tumors.
Luca Simula, Mattia Fumagalli, Lene Vimeux, Irena Rajnpreht, Philippe Icard

Nat Commun· March 2024

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FOXO1 Inhibition Generates Potent Nonactivated CAR T Cells against Solid Tumors.
Maude Marchais, Luca Simula, Mélanie Phayanouvong, Fathia Mami-Chouaib, Georges Bismuth

Cancer Immunol Res· November 2023

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The dual role of citrate in cancer.
Philippe Icard, Luca Simula, Grit Zahn, Marco Alifano, Maria E Mycielska

Biochim Biophys Acta Rev Cancer· November 2023

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The potential for citrate to reinforce epigenetic therapy by promoting apoptosis.
Philippe Icard, Marco Alifano, Luca Simula

Trends Endocrinol Metab· October 2023

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Metabolic oscillations during cell-cycle progression.
Philippe Icard, Luca Simula

Trends Endocrinol Metab· July 2022

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The strategic roles of four enzymes in the interconnection between metabolism and oncogene activation in non-small cell lung cancer: Therapeutic implications.
Philippe Icard, Luca Simula, Ludovic Fournel, Karen Leroy, Audrey Lupo

Drug Resist Updat· July 2022

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Immune Checkpoint Proteins, Metabolism and Adhesion Molecules: Overlooked Determinants of CAR T-Cell Migration?
Luca Simula, Emma Ollivier, Philippe Icard, Emmanuel Donnadieu

Cells· June 2022

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How Phosphofructokinase-1 Promotes PI3K and YAP/TAZ in Cancer: Therapeutic Perspectives.
Luca Simula, Marco Alifano, Philippe Icard

Cancers (Basel)· May 2022

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PD-1-induced T cell exhaustion is controlled by a Drp1-dependent mechanism.
Luca Simula, Ylenia Antonucci, Giorgia Scarpelli, Valeria Cancila, Alessandra Colamatteo

Mol Oncol· January 2022

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On the footsteps of Hippocrates, Sanctorius and Harvey to better understand the influence of cold on the occurrence of COVID-19 in European countries in 2020.
Philippe Icard, Luca Simula, Joana Rei, Ludovic Fournel, Vincent De Pauw

Biochimie· December 2021

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Why may citrate sodium significantly increase the effectiveness of transarterial chemoembolization in hepatocellular carcinoma?
Philippe Icard, Luca Simula, Zherui Wu, Diana Berzan, Philippe Sogni

Drug Resist Updat· December 2021

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Fructose-1,6-bisphosphate promotes PI3K and glycolysis in T cells?
Philippe Icard, Marco Alifano, Emmanuel Donnadieu, Luca Simula

Trends Endocrinol Metab· August 2021

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Following the Dynamism of the Mitochondrial Network in T Cells.
Arianna Di Daniele, Luca Simula, Silvia Campello

Methods Mol Biol· August 2021

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Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update.
Philippe Icard, Antoine Coquerel, Zherui Wu, Joseph Gligorov, David Fuks, Luca Simula

Int J Mol Sci· June 2021

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Correction: JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction.
Luca Simula, Mauro Corrado, Benedetta Accordi, Anthea Di Rita, Francesca Nazio

Cell Death Differ· November 2020

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JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction.
Luca Simula, Mauro Corrado, Benedetta Accordi, Anthea Di Rita, Francesca Nazio

Cell Death Differ· October 2020

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Thioridazine requires calcium influx to induce MLL-AF6-rearranged AML cell death.
Claudia Tregnago, Ambra Da Ros, Elena Porcù, Maddalena Benetton, Manuela Simonato, Luca Simula

Blood Adv· September 2020

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Targeting Drp1 and mitochondrial fission for therapeutic immune modulation.
Luca Simula, Michelangelo Campanella, Silvia Campello

Pharmacol Res· August 2019

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Reversible induction of mitophagy by an optogenetic bimodular system.
Pasquale D'Acunzo, Flavie Strappazzon, Ignazio Caruana, Giacomo Meneghetti, Anthea Di Rita, Luca Simula

Nat Commun· April 2019

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T lymphocytes against solid malignancies: winning ways to defeat tumours.
Ignazio Caruana, Luca Simula, Franco Locatelli, Silvia Campello

Cell Stress· July 2018

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