Publications by authors named "Luke Alphey"

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Synthetic homing endonuclease gene drives to revolutionise Aedes aegypti biocontrol - game changer or pipe dream?
Joshua Xd Ang, Sebald An Verkuijl, Michelle Ae Anderson, Luke Alphey

Curr Opin Insect Sci· August 2025

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Harnessing the highly adaptable barnase-barstar system for genetic biocontrol of Aedes aegypti.
Katherine Nevard, Joshua X D Ang, Michelle A E Anderson, Estela Gonzalez, Lewis Shackleford, Luke Alphey

Commun Biol· August 2025

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Meeting Report on an Integrated Research Agenda for Mosquito-Borne Arboviruses.
Angela K Ulrich, Nicolina M Moua, Alison Mack, Natsuko Imai-Eaton, J Erin Staples, Luke Alphey

Open Forum Infect Dis· July 2025

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Optimization of SgRNA expression with RNA pol III regulatory elements in Anopheles stephensi.
Estela Gonzalez, Michelle A E Anderson, Joshua X D Ang, Katherine Nevard, Lewis Shackleford, Luke Alphey

Sci Rep· April 2025

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Expanding the transgene expression toolbox of the malaria vector Anopheles stephensi.
Joshua Southworth, Estela Gonzalez, Katherine Nevard, Mireia Larrosa-Godall, Luke Alphey

Insect Mol Biol· February 2025

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Challenges in developing a split drive targeting dsx for the genetic control of the invasive malaria vector Anopheles stephensi.
Mireia Larrosa-Godall, Joshua X D Ang, Philip T Leftwich, Estela Gonzalez, Lewis Shackleford, Luke Alphey

Parasit Vectors· February 2025

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A change in circulating chikungunya virus variant impacts Aedes aegypti vector competence and spatiotemporal distribution of disease in Malaysia.
Izzati Kausar Azman, Yoke Fun Chan, Chong Long Chua, Zainal Abidin Abd Mutalib, Sarat Chandra Dass, Luke Alphey

PLoS Negl Trop Dis· October 2024

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A Synthetic Biology Approach to Transgene Expression in Insects.
Philip T Leftwich, Jessica C Purcell, Michelle A E Anderson, Rennos Fragkoudis, Sanjay Basu, Luke Alphey

ACS Synth Biol· September 2024

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A multiplexed, confinable CRISPR/Cas9 gene drive can propagate in caged Aedes aegypti populations.
Michelle A E Anderson, Estela Gonzalez, Matthew P Edgington, Joshua X D Ang, Deepak-Kumar Purusothaman, Luke Alphey

Nat Commun· January 2024

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Transgenic expression of cif genes from Wolbachia strain wAlbB recapitulates cytoplasmic incompatibility in Aedes aegypti.
Cameron J McNamara, Thomas H Ant, Tim Harvey-Samuel, Helen White-Cooper, Julien Martinez, Luke Alphey

Nat Commun· January 2024

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Engineered Antiviral Sensor Targets Infected Mosquitoes.
Elena Dalla Benetta, Adam J López-Denman, Hsing-Han Li, Reem A Masri, Daniel J Brogan, Luke S Alphey

CRISPR J· December 2023

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Sex or poison? Genetic pest management in the 21st century.
Luke Alphey

BMC Biol· December 2023

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CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus.
Tim Harvey-Samuel, Xuechun Feng, Emily M Okamoto, Deepak-Kumar Purusothaman, Philip T Leftwich, Luke Alphey

Nat Commun· November 2023

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AePUb promoter length modulates gene expression in Aedes aegypti.
Michelle A E Anderson, Philip T Leftwich, Ray Wilson, Leonela Z Carabajal Paladino, Sanjay Basu, Luke Alphey

Sci Rep· November 2023

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Mimicking superinfection exclusion disrupts alphavirus infection and transmission in the yellow fever mosquito .
Christine M Reitmayer, Emily Levitt, Sanjay Basu, Barry Atkinson, Rennos Fragkoudis, Luke Alphey

Proc Natl Acad Sci U S A· September 2023

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Optimizing CRE and PhiC31 mediated recombination in .
Leonela Z Carabajal Paladino, Ray Wilson, Priscilla Y L Tng, Vishaal Dhokiya, Elizabeth Keen, Luke Alphey

Front Bioeng Biotechnol· September 2023

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Susceptibility of Aedes albopictus, Ae. aegypti and human populations to Ross River virus in Kuala Lumpur, Malaysia.
Jolene Yin Ling Fu, Chong Long Chua, Athirah Shafiqah Abu Bakar, Indra Vythilingam, Wan Yusoff Wan Sulaiman, Luke Alphey

PLoS Negl Trop Dis· June 2023

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CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector .
Tim Harvey-Samuel, Xuechun Feng, Emily M Okamoto, Deepak-Kumar Purusothaman, Philip T Leftwich, Luke Alphey

bioRxiv· June 2023

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Closing the gap to effective gene drive in Aedes aegypti by exploiting germline regulatory elements.
Michelle A E Anderson, Estela Gonzalez, Joshua X D Ang, Lewis Shackleford, Katherine Nevard, Luke Alphey

Nat Commun· January 2023

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Engineered Antiviral Sensor Targets Infected Mosquitoes.
Elena Dalla Benetta, Adam J López-Denman, Hsing-Han Li, Reem A Masri, Daniel J Brogan, Luke S Alphey

bioRxiv· January 2023

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Silencing RNAs expressed from W-linked "retrocopies" target that gene during female sex determination in .
Tim Harvey-Samuel, Xuejiao Xu, Michelle A E Anderson, Leonela Z Carabajal Paladino, Deepak Purusothaman, Luke Alphey

Proc Natl Acad Sci U S A· November 2022

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A CRISPR endonuclease gene drive reveals distinct mechanisms of inheritance bias.
Sebald A N Verkuijl, Estela Gonzalez, Ming Li, Joshua X D Ang, Nikolay P Kandul, Luke Alphey

Nat Commun· November 2022

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Daisy-chain gene drives: The role of low cut-rate, resistance mutations, and maternal deposition.
Sebald A N Verkuijl, Michelle A E Anderson, Luke Alphey, Michael B Bonsall

PLoS Genet· September 2022

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The Acquisition and Retention of Lumpy Skin Disease Virus by Blood-Feeding Insects Is Influenced by the Source of Virus, the Insect Body Part, and the Time since Feeding.
Beatriz Sanz-Bernardo, Rey Suckoo, Ismar R Haga, Najith Wijesiriwardana, Alice Harvey, Luke Alphey

J Virol· August 2022

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