Publications by authors named "Luke R Smart"

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Reducing Harm in Cultural Transition: Repurposing the 5 Stages of Grief Model for Global Health Experiences.
Duncan K Hau, Grace Ruselu, Robert N Peck, Jennifer A Downs, Gloria J Manyangu, Luke R Smart

J Grad Med Educ· December 2025

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Hydroxyurea pharmacokinetics in children with sickle cell anemia across different global populations.
Alexandra Power-Hays, Kathryn E McElhinney, Thomas N Williams, George Mochamah, Peter Olupot-Olupot, Luke R Smart

Blood Adv· September 2025

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Hydroxyurea to decrease stroke risk in children with sickle cell anemia: a systematic review and meta-analysis.
Emmanuela E Ambrose, Paul Alikado Sabuni, Don P Jason Iii, Russell E Ware, Abel N Makubi, Luke R Smart

Blood Glob Hematol· June 2025

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Alpha+ Thalassemia in Northwestern Tanzania: Molecular and Hematological Insights From Newborn Screening.
Emmanuela E Ambrose, Benson R Kidenya, Luke R Smart, Alphaxard Manjurano

J Blood Med· May 2025

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Validation of Pediatric Self-Report Pain Scales in Sub-Saharan Africa: A Systematic Review.
Stephen Rineer, Derek Kwakye, Emmanuela E Ambrose, Iii Don P Jason, Luke R Smart

J Pain Symptom Manage· February 2025

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Hydroxyurea for Children and Adults with Hemoglobin SC Disease.
Yvonne A Dei-Adomakoh, Catherine I Segbefia, Teresa S Latham, Adam C Lane, Klenam Dzefi-Tettey, Luke R Smart

NEJM Evid· February 2025

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Causes and Consequences of Persistent Anemia after 6 Months of Antiretroviral Therapy in Tanzania: An Observational Comparative Cohort Study.
Duncan K Hau, Salama Fadhil, Myung Hee Lee, Bernard Desderius, Megan Willkens, Luke R Smart

Am J Trop Med Hyg· January 2025

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Baseline characteristics of Ghanaian children and adults enrolled in PIVOT, a randomised clinical trial of hydroxyurea in HbSC disease in sub-Saharan Africa.
Catherine I Segbefia, Luke R Smart, Susan E Stuber, Kwesi N Amissah-Arthur, Klenam Dzefi-Tettey

Br J Haematol· December 2024

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Rationale, Development, and Validation of HdxSim, a Clinical Decision Support Tool for Model-Informed Precision Dosing of Hydroxyurea for Children with Sickle Cell Anemia.
Alexandra Power-Hays, Min Dong, Nieko Punt, Tomoyuki Mizuno, Luke R Smart

Clin Pharmacol Ther· September 2024

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Pancytopenia in the Emergency Department.
Elizabeth C Lendrum, Luke R Smart, Adam A Vukovic

J Pediatr· September 2024

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Hydroxyurea dose optimisation for children with sickle cell anaemia in sub-Saharan Africa (REACH): extended follow-up of a multicentre, open-label, phase 1/2 trial.
Banu Aygun, Adam Lane, Luke R Smart, Brígida Santos, Léon Tshilolo

Lancet Haematol· June 2024

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Reducing transfusion utilization for children with sickle cell anemia in sub-Saharan Africa with hydroxyurea: Analysis from the phase I/II REACH trial.
Alexandra Power-Hays, George A Tomlinson, Leon Tshilolo, Brígida Santos, Thomas N Williams, Luke R Smart

Am J Hematol· April 2024

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Prospective identification of variables as outcomes for treatment (PIVOT): study protocol for a randomised, placebo-controlled trial of hydroxyurea for Ghanaian children and adults with haemoglobin SC disease.
Luke R Smart, Catherine I Segbefia, Teresa S Latham, Susan E Stuber, Kwesi N Amissah-Arthur

Trials· September 2023

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Hydroxyurea pharmacokinetics and precision dosing in low-resource settings.
Luke R Smart, Mwesige Charles, Kathryn E McElhinney, Min Dong, Alexandra Power-Hays

Front Mol Biosci· June 2023

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Risk of Bacteremia in Febrile Children and Young Adults With Sickle Cell Disease in a Multicenter Emergency Department Cohort.
Stephen Rineer, Patrick S Walsh, Luke R Smart, Nusrat Harun, David Schnadower

JAMA Netw Open· June 2023

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Hydroxyurea with dose escalation for primary stroke risk reduction in children with sickle cell anaemia in Tanzania (SPHERE): an open-label, phase 2 trial.
Emmanuela E Ambrose, Teresa S Latham, Primrose Songoro, Mwesige Charles, Adam C Lane, Luke R Smart

Lancet Haematol· April 2023

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Stroke Prevention with Hydroxyurea Enabled through Research and Education: A Phase 2 Primary Stroke Prevention Trial in Sub-Saharan Africa.
Luke R Smart, Emmanuela E Ambrose, Georgina Balyorugulu, Primrose Songoro, Idd Shabani

Acta Haematol· March 2023

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Hydroxyurea treatment is associated with lower malaria incidence in children with sickle cell anemia in sub-Saharan Africa.
Peter Olupot-Olupot, George Tomlinson, Thomas N Williams, Léon Tshilolo, Brígida Santos, Luke R Smart

Blood· March 2023

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Health Related Quality of Life among Children with Sickle Cell Anaemia in Northwestern Tanzania.
Zivonishe Mwazyunga, Emmanuela E Ambrose, Neema Kayange, Respicious Bakalemwa, Benson Kidenya, Luke R Smart

Open J Blood Dis· June 2022

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Pediatric Hydrocephalus in Northwest Tanzania: A Descriptive Cross-Sectional Study of Clinical Characteristics and Early Surgical Outcomes from the Bugando Medical Centre.
Camilla G Aukrust, Karishma Parikh, Luke R Smart, Ibrahimu Mdala, Heidi E Fjeld

World Neurosurg· May 2022

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Early initiation of hydroxyurea (hydroxycarbamide) using individualised, pharmacokinetics-guided dosing can produce sustained and nearly pancellular expression of fetal haemoglobin in children with sickle cell anaemia.
Charles T Quinn, Omar Niss, Min Dong, Amanda Pfeiffer, Jennifer Korpik, Luke R Smart

Br J Haematol· August 2021

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Newborn screening for sickle cell disease in sub-Saharan Africa: Is the glass half-full yet?
Luke R Smart, Russell E Ware

Pediatr Blood Cancer· July 2021

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Linkage to Care Intervention to Improve Post-Hospital Outcomes Among Children with Sickle Cell Disease in Tanzania: A Pilot Study.
Duncan K Hau, Emmanuela E Ambrose, Luke R Smart, Neema M Kayange, Robert N Peck

J Pediatr· May 2021

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Surveillance for sickle cell disease, United Republic of Tanzania.
Emmanuela E Ambrose, Luke R Smart, Mwesige Charles, Arielle G Hernandez, Teresa Latham

Bull World Health Organ· December 2020

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AnemoCheck-LRS: an optimized, color-based point-of-care test to identify severe anemia in limited-resource settings.
Marina S Perez-Plazola, Erika A Tyburski, Luke R Smart, Thad A Howard, Amanda Pfeiffer

BMC Med· November 2020

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