Publications by authors named "Lusong Luo"

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Discovery of BGB-8035, a Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase for B-Cell Malignancies and Autoimmune Diseases.
Yunhang Guo, Nan Hu, Ye Liu, Wei Zhang, Desheng Yu, Lusong Luo

J Med Chem· March 2023

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Discovery of Pamiparib (BGB-290), a Potent and Selective Poly (ADP-ribose) Polymerase (PARP) Inhibitor in Clinical Development.
Hexiang Wang, Bo Ren, Ye Liu, Beibei Jiang, Yin Guo, Lusong Luo

J Med Chem· December 2020

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Design, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity.
Zhanhui Li, Xu Wang, Yu Lin, Yujie Wang, Shuwei Wu, Lusong Luo

Eur J Med Chem· November 2020

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RAF dimer inhibition enhances the antitumor activity of MEK inhibitors in K-RAS mutant tumors.
Xi Yuan, Zhiyu Tang, Rong Du, Zhan Yao, Shing-Hu Cheung, Lusong Luo

Mol Oncol· August 2020

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Phase I, Open-Label, Dose-Escalation/Dose-Expansion Study of Lifirafenib (BGB-283), an RAF Family Kinase Inhibitor, in Patients With Solid Tumors.
Jayesh Desai, Hui Gan, Catherine Barrow, Michael Jameson, Victoria Atkinson, Lusong Luo

J Clin Oncol· July 2020

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Design, Synthesis, and Characterization of Novel CXCR4 Antagonists Featuring Cyclic Amines.
Yu Lin, Zhanhui Li, Haikuo Ma, Yujie Wang, Xu Wang, Lusong Luo

ChemMedChem· July 2020

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Design, synthesis, and evaluation of novel CXCR4 antagonists based on an aminoquinoline template.
Yu Lin, Zhanhui Li, Chen Xu, Kaijiang Xia, Shuwei Wu, Lusong Luo

Bioorg Chem· June 2020

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Structural optimization of aminopyrimidine-based CXCR4 antagonists.
Fang Zhu, Yujie Wang, Qian Du, Wenxiang Ge, Zhanhui Li, Lusong Luo

Eur J Med Chem· February 2020

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Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
Yunhang Guo, Ye Liu, Nan Hu, Desheng Yu, Changyou Zhou, Lusong Luo

J Med Chem· September 2019

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Structural optimization on a virtual screening hit of smoothened receptor.
Shiwei Song, Jinyi Jiang, Li Zhao, Qin Wang, Wenfeng Lu, Lusong Luo

Eur J Med Chem· June 2019

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Discovery of potent and novel smoothened antagonists via structure-based virtual screening and biological assays.
Wenfeng Lu, Dihua Zhang, Haikuo Ma, Sheng Tian, Jiyue Zheng, Lusong Luo

Eur J Med Chem· July 2018

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Discovery of a potent hedgehog pathway inhibitor capable of activating caspase8-dependent apoptosis.
Qin Chen, Haoran Zhang, Meng Wu, Qin Wang, Lusong Luo

J Pharmacol Sci· July 2018

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Design, synthesis, and structure-activity-relationship of a novel series of CXCR4 antagonists.
Zhanhui Li, Yujie Wang, Chunyan Fu, Xu Wang, Jun Jun Wang, Lusong Luo

Eur J Med Chem· April 2018

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Discovery and characterization of a potent Wnt and hedgehog signaling pathways dual inhibitor.
Haikuo Ma, Qin Chen, Fang Zhu, Jiyue Zheng, Jiajun Li, Lusong Luo

Eur J Med Chem· April 2018

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Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia.
Jennifer L Ariazi, Kevin J Duffy, David F Adams, Duke M Fitch, Lusong Luo

J Pharmacol Exp Ther· December 2017

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Design, Synthesis, and Structure-Activity Relationship of Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Potent Smoothened Antagonists with in Vivo Activity.
Wenfeng Lu, Yongqiang Liu, Haikuo Ma, Jiyue Zheng, Sheng Tian, Lusong Luo

ACS Chem Neurosci· September 2017

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Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the 'reversed' amide scaffold.
Zhixiang Xu, Xiangxiang Xu, Ruadhan O'Laoi, Haikuo Ma, Jiyue Zheng, Lusong Luo

Bioorg Med Chem· November 2016

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Discovery of novel dihydrobenzofuran cyclopropane carboxylic acid based calcium sensing receptor antagonists for the treatment of osteoporosis.
Gui-Bai Liang, Changyou Zhou, Xianghong Huo, Hank Wang, Xuelin Yang, Lusong Luo

Bioorg Med Chem Lett· August 2016

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Design, synthesis, and evaluation of potent Wnt signaling inhibitors featuring a fused 3-ring system.
Zhixiang Xu, Jiajun Li, Yiyuan Wu, Zhijian Sun, Lusong Luo

Eur J Med Chem· January 2016

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Exploration of the linkage elements of porcupine antagonists led to potent Wnt signaling pathway inhibitors.
Yan Dong, Kehuang Li, Zhixiang Xu, Haikuo Ma, Jiyue Zheng, Lusong Luo

Bioorg Med Chem· November 2015

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BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers.
Zhiyu Tang, Xi Yuan, Rong Du, Shing-Hu Cheung, Guoliang Zhang, Lusong Luo

Mol Cancer Ther· October 2015

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Discovery of a 6-(pyridin-3-yl)benzo[d]thiazole template for optimization of hedgehog and PI3K/AKT/mTOR dual inhibitors.
Zhaohui Yang, Haikuo Ma, Zhijian Sun, Lusong Luo, Sheng Tian

Bioorg Med Chem Lett· September 2015

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BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition.
Zhan Yao, Neilawattie M Torres, Anthony Tao, Yijun Gao, Lusong Luo

Cancer Cell· September 2015

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The extent of inflammatory infiltration in primary cancer tissues is associated with lymphomagenesis in immunodeficient mice.
Lianhai Zhang, Yiqiang Liu, Xiaohong Wang, Zhiyu Tang, Shuangxi Li, Lusong Luo

Sci Rep· March 2015

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Design, synthesis, and structure--activity-relationship of tetrahydrothiazolopyridine derivatives as potent smoothened antagonists.
Haikuo Ma, Wenfeng Lu, Zhijian Sun, Lusong Luo, Delong Geng

Eur J Med Chem· January 2015

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