Publications by authors named "Lyann Sim"

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Synthesis and evaluation of carbagalactosyl 1,2-aziridines and -epoxides as glycosidase inhibitors.
Yuqing Tian, Hong-Ming Chen, Lyann Sim, Seyed A Nasseri, Jolene P Reid

Org Biomol Chem· December 2025

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An alternative broad-specificity pathway for glycan breakdown in bacteria.
Seyed Amirhossein Nasseri, Aleksander C Lazarski, Imke L Lemmer, Chloe Y Zhang, Eva Brencher, Lyann Sim

Nature· July 2024

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A high-throughput screening platform for enzymes active on mucin-type O-glycoproteins.
Jacob F Wardman, Lyann Sim, Jennifer Liu, Teresa A Howard, Andreas Geissner

Nat Chem Biol· October 2023

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Vinyl Halide-Modified Unsaturated Cyclitols are Mechanism-Based Glycosidase Inhibitors.
Phillip M Danby, Andrew Jeong, Lyann Sim, Ryan P Sweeney, Jacob F Wardman

Angew Chem Int Ed Engl· May 2023

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Mammalian sialyltransferases allow efficient Escherichia coli-based production of mucin-type O-glycoproteins but can also transfer Kdo.
Lyann Sim, Nicole Thompson, Andreas Geissner, Stephen G Withers, Warren W Wakarchuk

Glycobiology· April 2022

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Discovery and Development of Promiscuous O-Glycan Hydrolases for Removal of Intact Sialyl T-Antigen.
Jacob F Wardman, Peter Rahfeld, Feng Liu, Connor Morgan-Lang, Lyann Sim

ACS Chem Biol· October 2021

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Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers.
Erika M J Siren, Haiming D Luo, Franklin Tam, Ashani Montgomery, Winnie Enns, Lyann Sim

Nat Biomed Eng· October 2021

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7-Fluorosialyl Glycosides Are Hydrolysis Resistant but Readily Assembled by Sialyltransferases Providing Easy Access to More Metabolically Stable Glycoproteins.
Andreas Geissner, Lars Baumann, Thomas J Morley, Andrew K O Wong, Lyann Sim

ACS Cent Sci· February 2021

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An enzymatic pathway in the human gut microbiome that converts A to universal O type blood.
Peter Rahfeld, Lyann Sim, Haisle Moon, Iren Constantinescu, Connor Morgan-Lang

Nat Microbiol· September 2019

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Comparison of α2,6-sialyltransferases for sialylation of therapeutic proteins.
Bettina Janesch, Hirak Saxena, Lyann Sim, Warren W Wakarchuk

Glycobiology· September 2019

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Directed evolution of bacterial polysialyltransferases.
Bettina Janesch, Lars Baumann, Alison Mark, Nicole Thompson, Sadia Rahmani, Lyann Sim

Glycobiology· July 2019

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A Bacterial Expression Platform for Production of Therapeutic Proteins Containing Human-like O-Linked Glycans.
Ting Du, Nakita Buenbrazo, Laura Kell, Sadia Rahmani, Lyann Sim

Cell Chem Biol· February 2019

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Characterization of a thermostable endoglucanase from Cellulomonas fimi ATCC484.
Hirak Saxena, Bryan Hsu, Marc de Asis, Mirko Zierke, Lyann Sim

Biochem Cell Biol· February 2018

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X-ray crystallographic structure of a bacterial polysialyltransferase provides insight into the biosynthesis of capsular polysialic acid.
Christian Lizak, Liam J Worrall, Lars Baumann, Moritz M Pfleiderer, Gesa Volkers, Lyann Sim

Sci Rep· July 2017

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Oligosaccharide and substrate binding in the starch debranching enzyme barley limit dextrinase.
Marie S Møller, Michael S Windahl, Lyann Sim, Marie Bøjstrup, Maher Abou Hachem

J Mol Biol· March 2015

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Crystal structure of the Chlamydomonas starch debranching enzyme isoamylase ISA1 reveals insights into the mechanism of branch trimming and complex assembly.
Lyann Sim, Sophie R Beeren, Justin Findinier, David Dauvillée, Steven G Ball

J Biol Chem· August 2014

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Convergent evolution of polysaccharide debranching defines a common mechanism for starch accumulation in cyanobacteria and plants.
Ugo Cenci, Malika Chabi, Mathieu Ducatez, Catherine Tirtiaux, Jennifer Nirmal-Raj, Lyann Sim

Plant Cell· October 2013

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Structural and biochemical characterization of the N-terminal domain of flocculin Lg-Flo1p from Saccharomyces pastorianus reveals a unique specificity for phosphorylated mannose.
Lyann Sim, Magnus Groes, Kjeld Olesen, Anette Henriksen

FEBS J· February 2013

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Unexpected high digestion rate of cooked starch by the Ct-maltase-glucoamylase small intestine mucosal α-glucosidase subunit.
Amy Hui-Mei Lin, Buford L Nichols, Roberto Quezada-Calvillo, Stephen E Avery, Lyann Sim

PLoS One· September 2012

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Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase.
Kyra Jones, Lyann Sim, Sankar Mohan, Jayakanthan Kumarasamy, Hui Liu

Bioorg Med Chem· July 2011

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Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membered ring nitrogen analogue of kotalanol and its de-O-sulfonated derivative.
Sankar Mohan, Lyann Sim, David R Rose, B Mario Pinto

Bioorg Med Chem· November 2010

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Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains.
Lyann Sim, Carly Willemsma, Sankar Mohan, Hassan Y Naim, B Mario Pinto

J Biol Chem· June 2010

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New glucosidase inhibitors from an ayurvedic herbal treatment for type 2 diabetes: structures and inhibition of human intestinal maltase-glucoamylase with compounds from Salacia reticulata.
Lyann Sim, Kumarasamy Jayakanthan, Sankar Mohan, Ravindranath Nasi, Blair D Johnston

Biochemistry· January 2010

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Total syntheses of casuarine and its 6-O-alpha-glucoside: complementary inhibition towards glycoside hydrolases of the GH31 and GH37 families.
Francesca Cardona, Camilla Parmeggiani, Enrico Faggi, Claudia Bonaccini, Paola Gratteri, Lyann Sim

Chemistry· March 2009

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Studies directed toward the stereochemical structure determination of the naturally occurring glucosidase inhibitor, kotalanol: synthesis and inhibitory activities against human maltase glucoamylase of seven-carbon, chain-extended homologues of salacinol.
Ravindranath Nasi, Brian O Patrick, Lyann Sim, David R Rose, B Mario Pinto

J Org Chem· August 2008

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