Publications by authors named "Lydia W Cheung"

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p85β acts as a transcription cofactor and cooperates with BCLAF1 in the nucleus.
Panpan Wang, Victor Cy Mak, Ling Rao, Qiuqiu Wu, Yuan Zhou, Lydia Wt Cheung

Nat Commun· February 2025

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Single-cell transcriptomic analysis uncovers intratumoral heterogeneity and drug-tolerant persister in ALK-rearranged lung adenocarcinoma.
Hoi-Hin Kwok, Huiyu Li, Jiashuang Yang, Junyang Deng, Nerissa Chui-Mei Lee, Lydia Wai-Ting Cheung

Cancer Commun (Lond)· August 2023

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Drugging IGF-1R in cancer: New insights and emerging opportunities.
Panpan Wang, Victor Cy Mak, Lydia Wt Cheung

Genes Dis· January 2023

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p85β alters response to EGFR inhibitor in ovarian cancer through p38 MAPK-mediated regulation of DNA repair.
Victor Cy Mak, Xinran Li, Ling Rao, Yuan Zhou, Sai-Wah Tsao, Lydia Wt Cheung

Neoplasia· July 2021

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Preclinical evaluation and reverse phase protein Array-based profiling of PI3K and MEK inhibitors in endometrial carcinoma in vitro.
Ozlem Aslan, Mattia Cremona, Clare Morgan, Lydia W Cheung, Gordon B Mills

BMC Cancer· February 2018

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p85α neomorphic mutants: splitting away from the canonical path.
Lydia Wt Cheung, Gordon B Mills

Mol Cell Oncol· June 2016

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Targeting therapeutic liabilities engendered by PIK3R1 mutations for cancer treatment.
Lydia Wt Cheung, Gordon B Mills

Pharmacogenomics· February 2016

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Regulation of the PI3K pathway through a p85α monomer-homodimer equilibrium.
Lydia W T Cheung, Katarzyna W Walkiewicz, Tabot M D Besong, Huifang Guo, David H Hawke

Elife· July 2015

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Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors.
Lydia W T Cheung, Shuangxing Yu, Dong Zhang, Jie Li, Patrick K S Ng

Cancer Cell· October 2014

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Somatic mutations of PIK3R1 promote gliomagenesis.
Steven N Quayle, Jennifer Y Lee, Lydia W T Cheung, Li Ding, Ruprecht Wiedemeyer

PLoS One· May 2013

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Targeting gonadotropin-releasing hormone receptor inhibits the early step of ovarian cancer metastasis by modulating tumor-mesothelial adhesion.
Lydia W T Cheung, Susan Yung, Tak-Mao Chan, Peter C K Leung, Alice S T Wong

Mol Ther· January 2013

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Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.
Han Liang, Lydia W T Cheung, Jie Li, Zhenlin Ju, Shuangxing Yu

Genome Res· November 2012

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High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.
Lydia W T Cheung, Bryan T Hennessy, Jie Li, Shuangxing Yu, Andrea P Myers

Cancer Discov· July 2011

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Ginsenoside-Rg1 induces angiogenesis via non-genomic crosstalk of glucocorticoid receptor and fibroblast growth factor receptor-1.
Lydia W T Cheung, Kar Wah Leung, Chris K C Wong, Ricky N S Wong, Alice S T Wong

Cardiovasc Res· February 2011

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Gonadotropin-releasing hormone: GnRH receptor signaling in extrapituitary tissues.
Lydia W T Cheung, Alice S T Wong

FEBS J· November 2008

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Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian cancer cells through estrogen receptor alpha.
Se-Hyung Park, Lydia W T Cheung, Alice S T Wong, Peter C K Leung

Mol Endocrinol· September 2008

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CpG/CpNpG motifs in the coding region are preferred sites for mutagenesis in the breast cancer susceptibility genes.
Lydia W T Cheung, Yiu Fai Lee, Tuen Wai Ng, Wai Ki Ching, Ui Soon Khoo

FEBS Lett· October 2007

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Differential role of gonadotropin-releasing hormone on human ovarian epithelial cancer cell invasion.
Chien-Lin Chen, Lydia W T Cheung, Man-Tat Lau, Jung-Hye Choi, Nelly Auersperg

Endocrine· June 2007

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Gonadotropin-releasing hormone promotes ovarian cancer cell invasiveness through c-Jun NH2-terminal kinase-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9.
Lydia W T Cheung, Peter C K Leung, Alice S T Wong

Cancer Res· November 2006

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Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells.
Lydia W T Cheung, Simon C L Au, Annie N Y Cheung, Hextan Y S Ngan, Joyce Tombran-Tink

Endocrinology· September 2006

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