Publications by authors named "Lynsey Shaffer"

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Establishment of a 96-well transwell system using primary human gut organoids to capture multiple quantitative pathway readouts.
Charles W Wright, Naomi Li, Lynsey Shaffer, Armetta Hill, Nicolas Boyer

Sci Rep· September 2023

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Discovery of a new series of PI3K-δ inhibitors from Virtual Screening.
Xavier Fradera, Qiaolin Deng, Abdelganhi Achab, Yudith Garcia, Solomon D Kattar, Lynsey Shaffer

Bioorg Med Chem Lett· June 2021

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Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators.
Joey L Methot, Hua Zhou, Meredeth A McGowan, Neville John Anthony, Matthew Christopher, Lynsey Shaffer

J Med Chem· April 2021

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Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors.
Brian M Lacey, Zangwei Xu, Xiaomei Chai, Jason Laskey, Xavier Fradera, Lynsey Shaffer

SLAS Discov· January 2021

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Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors.
Hua Zhou, Meredeth A McGowan, Kathryn Lipford, Matthew Christopher, Xavier Fradera, Lynsey Shaffer

Bioorg Med Chem Lett· January 2020

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Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability.
Joey L Methot, Hua Zhou, Sam D Kattar, Meredeth A McGowan, Kevin Wilson, Lynsey Shaffer

J Med Chem· May 2019

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The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties.
Tony Siu, Jason Brubaker, Peter Fuller, Luis Torres, Hongbo Zeng, Lynsey Shaffer

J Med Chem· December 2017

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